ETV6 (NM_001987) Human Untagged Clone

CAT#: SC118922

ETV6 (untagged)-Human ets variant 6 (ETV6)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ETV6
• Synonyms: TEL; TEL/ABL; THC5
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001987 edited
  GAATTCGGCACGAGGAAACTTCTTAAATGACCGCGTCTGGCTGGCCGTGGAGCCTTTCTG
  GGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGT
  GAGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACAC
  CTCCAGAGAGCCCAGTGCCGAGTTACGCTTCCTCGACGCCACTTCATGTTCCAGTGCCTC
  GAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAA
  TTTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTT
  TAAGGCCAATTGACAGCAACACGTTTGAAATGAATGGCAAAGCTCTCCTGCTGCTGACCA
  AAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGC
  ATATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACT
  CTATACACACACAGCCGGAGGTCATACTGCATCAGAACCATGAAGAAGATAACTGTGTCC
  AGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGT
  TGCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGC
  GGCCCCTCCGGTCCCCCCTGGACAACATGATCCGCCGCCTCTCCCCGGCTGAGAGAGCTC
  AGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTC
  CCATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCC
  GGCAGGAGAGCACACGCGTGATCCAGCTGATGCCCAGCCCCATCATGCACCCTCTGATCC
  TGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATA
  GGGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCA
  TGGTCTCTGTCTCCCCGCCTGAAGAGCACGCCATGCCCATTGGGAGAATAGCAGACTGTA
  GACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAACTTCATCC
  GATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGAC
  TGTGGGGAAACCATAAGAACAGAACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGC
  GCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTGTTCAGGT
  TTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGT
  CCCAGGAGCTGGATGAACAAATATACCAAGAAGATGAATGCTGAAGGAACCAACAGTCCA
  CCTCAGCGGGCCAGCAGCCCAGGGAACCCCTGCCCACCAGGATTGCTGGAAGTGTGACGG
  AGCAGGCGGGCTGAGGAGAGTGGAAAAGGAAGCGACCCAGAAATGGCAGGGACACTTCTC
  TTGCAGACCAAGAGGGACCCTGGAGCACCTTAGACAAACTACCCAGCACAGGCGGGGCTG
  GAATTCTGGCGGAGGGCACGAGCCTGGGACTCCATGTCACGTTTCCTTCTGATTTGGAAT
  CTCTCCATCTGTAATTCCTCACCCTCACCCTTCCACCGTTGTTAGTATCATGGTGTTTTT
  GTTTTTGTTTTTGTTTTAAGAACCTGCAGTTTGACTCTTCATCGTTCATCTAGGGGAAGA
  CATCTGATGTTGTTTTCCTATGGAAATATATATCTATTATATATATATATTTTTTGCAAA
  TCTCACAAAGTGCGGCAAGCCCAGCTGGTCAGGAAAGAGAATACTTGCAGAGGGGTTCAG
  GTTCCTCTTTTTCCTGCCACGTGGATCAGGTCTGTTCCTGTTACTGTTGGGTCTTGGCTG
  AAAAAAAAAAAATGXXXXXXXXXXXXXXXXXXXXXXCTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001987 unedited
  GTCATACTTTGTATACGACTCATATAGGCGGCCGCNGAATTCGCACGAGGAAACTTCTTA
  AAGGACCGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAAGGAAGTGG
  AAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTGAGACATGTCTGAGACTCCTGCTCA
  GTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAAAGCCCAGTGCCGAGTTA
  CGCTTCCTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTC
  GATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAATTTACTGGAGCAGGGATGACGTAGC
  CCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTT
  TGAAATGAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCC
  TCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCATATTCTGAAGCAGAGGAAACCTCG
  GATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCAT
  ACTGCATCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGA
  TAATGTGCACCATAACCCTCCCACCTTGAACTGTTGCACCGCTCCAGGTCACCTATCACG
  ACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCAGCCCCCTCAGTCCCCCCTGGACACA
  TGATCCGCCGCCTCTCCCCGGCTGAGAGAGCTCATGGGACCCAGCCGCACCAGAGAACAT
  CACCAGGAGTCCTACCCTCTGTCAGTGTCTNCATGGGAGATAATCCTGCCCAGCGTCCTT
  CGAGTCCACCCNGAGCATNCAGCNCNCGGCAGATAGCCAAGCGTGATCAACTGATGC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001987 unedited
  GAAATCTCCTTTTCATGTTACTTTTTTAAAACCTTTTTTTTTTTTCAGCCAANACCCAAC
  AGTAACAGGAACAGACCTGATCCACGTGGCAGGAAAAAGAGAACCTGAACCCCTCTGCAA
  GTATTCTCTTTCCTGACCAGCTGGGCTTGCCGCACTTTGTGAGATTTGCAAAAAATATAT
  ATATATAATAGATATATANTTTCCATTAGGAAAACAACATCAGATGTCTTCCCCTAGATG
  AACGATGAAGAGTCAAACTGCAGGTTCTTAAAACAAAAACAAAAACAAAAACACCATGAT
  ACTAACAACGGTGGAAGGGTGAGGGTGAGGAATTACAGATGGAGAGATTCCAAATCAGAA
  GGAAACGTGACATGGAGTCCCAGGCTCGTGCCCTCCGCCAGAATTCCAGCCCCGCCTGTG
  CTGGGTAGTTTGTCTAAGGTGCTCCAGGGTCCCTCTTGGTCTGCAAGAGAAGTGTCCCTG
  CCATTTCTGGGTCGCTTCCTTTTCCACTCTCCTCAGCCCGCCTGCTCCGTCACACTTCCA
  GCAATCCTGGTGGGCAGGGGTTCCCTGGGCTGCTGGCCCGCTGAGGTGGACTGTTGGTTC
  CTTCAGCATTCATCTTCTTGGTATATTTGTTCATCCAGCTCCTGGGACTCTANGTGCTCC
  AGACGGTCTGTTCGGCCACTCATGATTTCATCTGGGGGTTTCATAAACCTGAACAAAAGC
  CNTTTGCCTGGCTCCTTCCTGATAAATGTTANTTTGGAGTAGTGGCGCAAGGCTCTGGAC
  ATTNTCTCATAGGCATGTTTGTTCTGGTCTTATGGTTCCCACAGTCGAGCACTCCGTGGG
  GATCACTATCCGGGATATTGGGATCTTGGGCTCCATCGGTGAAGTTTTCTCCCGGCTGTC
  AAAACACTGATGACGTATTCAAACC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001987
• Insert Size: 2240 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001987.3, NP_001978.1
• RefSeq Size: 5992 bp
• RefSeq ORF: 1359 bp
• Locus ID: 2120
• UniProt ID: P41212
• Cytogenetics: 12p13.2
• Domains: ETS, SAM_PNT
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Dorso-ventral axis formation
• Gene Summary: This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]