TGF beta Receptor III (TGFBR3) (NM_003243) Human Untagged Clone

CAT#: SC118073

TGFBR3 (untagged)-Human transforming growth factor, beta receptor III (TGFBR3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TGF beta Receptor III
• Synonyms: betaglycan; BGCAN
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC118073 sequence for NM_003243 edited (data generated by NextGen Sequencing)
  ATGACTTCCCATTATGTGATTGCCATCTTTGCCCTGATGAGCTCCTGTTTAGCCACTGCA
  GGTCCAGAGCCTGGTGCACTGTGTGAACTGTCACCTGTCAGTGCCTCCCATCCTGTCCAG
  GCCTTGATGGAGAGCTTCACTGTTTTGTCAGGCTGTGCCAGCAGAGGCACAACTGGGCTG
  CCACAGGAGGTGCATGTCCTGAATCTCCGCACTGCAGGCCAGGGGCCTGGCCAGCTACAG
  AGAGAGGTCACACTTCACCTGAATCCCATCTCCTCAGTCCACATCCACCACAAGTCTGTT
  GTGTTCCTGCTCAACTCCCCACACCCCCTGGTGTGGCATCTGAAGACAGAGAGACTTGCC
  ACTGGGGTCTCCAGACTGTTTTTGGTGTCTGAGGGTTCTGTGGTCCAGTTTTCATCAGCA
  AACTTCTCCTTGACAGCAGAAACAGAAGAAAGGAACTTCCCCCATGGAAATGAACATCTG
  TTAAATTGGGCCCGAAAAGAGTATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCA
  AGAAACATTTATATTAAAGTGGGGGAAGATCAAGTGTTCCCTCCAAAGTGCAACATAGGG
  AAGAATTTTCTCTCACTCAATTACCTTGCTGAGTACCTTCAACCCAAAGCAGCAGAAGGG
  TGTGTGATGTCCAGCCAGCCCCAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCC
  AACTCTAACCCCTACAGTGCTTTCCAGGTGGATATAACAATTGATATAAGACCTTCTCAA
  GAGGATCTTGAAGTGGTCAAAAATCTCATCCTGATCTTGAAGTGCAAAAAGTCTGTCAAC
  TGGGTGATCAAATCTTTTGATGTTAAGGGAAGCCTGAAAATTATTGCTCCTAACAGTATT
  GGCTTTGGAAAAGAGAGTGAAAGATCTATGACAATGACCAAATCAATAAGAGATGACATT
  CCTTCAACCCAAGGGAATCTGGTGAAGTGGGCTTTGGACAATGGCTATAGTCCAATAACT
  TCATACACAATGGCTCCTGTGGCTAATAGATTTCATCTTCGGCTTGAAAATAATGCAGAG
  GAGATGGGAGATGAGGAAGTCCACACTATTCCTCCTGAGCTACGGATCCTGCTGGACCCT
  GGTGCCCTGCCTGCCCTGCAGAACCCGCCCATCCGGGGAGGGGAAGGCCAAAATGGAGGC
  CTTCCGTTTCCTTTCCCAGATATTTCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGG
  CTCCCTCGGCCAAAGGACCCTGTCATTCCCAGCATACAACTGTTTCCTGGTCTCAGAGAG
  CCAGAAGAGGTGCAAGGGAGCGTGGATATTGCCCTGTCTGTCAAATGTGACAATGAGAAG
  ATGATCGTGGCTGTAGAAAAAGATTCTTTTCAGGCCAGTGGCTACTCGGGGATGGACGTC
  ACCCTGTTGGATCCTACCTGCAAGGCCAAGATGAATGGCACACACTTTGTTTTGGAGTCT
  CCTCTGAATGGCTGCGGTACTCGGCCCCGGTGGTCAGCCCTTGATGGTGTGGTCTACTAT
  AACTCCATTGTGATACAGGTTCCAGCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTAT
  GAAGATCTGGAGTCAGGTGATAATGGATTTCCGGGAGATATGGATGAAGGAGATGCTTCC
  CTGTTCACCCGACCTGAAATCGTGGTGTTTAATTGCAGCCTTCAGCAGGTGAGGAACCCC
  AGCAGCTTCCAGGAACAGCCCCACGGAAACATCACCTTCAACATGGAGCTATACAACACT
  GACCTCTTTTTGGTGCCCTCCCAGGGCGTCTTCTCTGTGCCAGAGAATGGACACGTTTAT
  GTTGAGGTATCTGTTACTAAGGCTGAACAAGAACTGGGATTTGCCATCCAAACGTGCTTT
  ATCTCTCCATATTCGAACCCTGATAGGATGTCTCATTACACCATTATTGAGAATATTTGT
  CCTAAAGATGAATCTGTGAAATTCTACAGTCCCAAGAGAGTGCACTTTCCTATCCCGCAA
  GCTGACATGGATAAGAAGCGATTCAGCTTTGTCTTCAAGCCTGTCTTCAACACCTCACTG
  CTCTTTCTACAGTGTGAGCTGACGCTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTG
  CCTAAGTGTGTGCCTCCTGACGAAGCCTGCACCTCGCTGGACGCCTCGATAATCTGGGCC
  ATGATGCAGAATAAGAAGACGTTCACTAAGCCCCTTGCTGTGATCCACCATGAAGCAGAA
  TCTAAAGAAAAAGGTCCAAGCATGAAGGAACCAAATCCAATTTCTCCACCAATTTTCCAT
  GGTCTGGACACCCTAACCGTGATGGGCATTGCGTTTGCAGCCTTTGTGATCGGAGCACTC
  CTGACGGGGGCCTTGTGGTACATCTATTCTCACACAGGGGAGACAGCAGGAAGGCAGCAA
  GTCCCCACCTCCCCGCCAGCCTCGGAAAACAGCAGTGCTGCCCACAGCATCGGCAGCACG
  CAGAGCACGCCTTGCTCCAGCAGCAGCACGGCCTAG
  
  Clone variation with respect to NM_003243.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003243 unedited
  GCTTTTGTATACGACTCACTATAGGGCGGCCGCGAATTCGCACGAGGGTGAAGGAGGGCA
  GTCGGCGGCTCTCGCGCCCCGGCCACTTTCCCTGCGCGATTCCCGGAGCTCCCTGCAGGA
  GGTGAGAGTCCCCAGCGGGTCCGGATGGCGTAGTTTTGCCGCGGCGCAGCAGCTGCCGGA
  GCTCGCCGCCGCCGAGCGCTGGGCGGGGAAACTTGCCGCCGCTTTCCTCCAACTTGCTGC
  GGGTGGATCTCCGCTGGACACACCGCCTCCGAGGCAGTTTGAAAATTGCAAGGAGGGACT
  TTAAGACTACTTCTGATTTGCAAAGATTGTCTGTGCTCTGAGCAGGCTGAAGTGACTGGA
  CGAGACGCACTGTTGGAGAAATAAAAATGACTTCCCATTATGTGATTGCCATCTTTGCCC
  TGATGAGCTCCTGTTTAGCCACTGCAGGTCCAGAGCCTGGTGCACTGTGTGAACTGTCAC
  CTGTCAGTGCCTCCCATCCTGTCCAGGCCTTGATGGAGAGCTTCACTGTTTTGTCAGGCT
  GTGCCAGCAGAGGCACAACTGGGCTGCCACAGGAGGTGCATGTCCTGAATCTCCGCACTG
  CAGGCCAGGGGCCTGGCCAGCTACAGAGAGAGGTCACACTTCACCTGAATCCCATCTCCT
  CAGTCCACATCCACCACAAGTCTGTTGTGGTCCTGCTCAACTCCCCCCACCCCCTGGTGT
  GGCATCTGTAGACAGAGAGACTCGCCACTGNGGTCTCCAGACTGTTTTTGGTGTCTGAAG
  GTTCTGTGGTCCAGTTTTTATCAACAAACTTCTCCTTGGCAGCCCGAACCAGAAGAAAGG
  AACTTCCCCCATGAAAAGAACATCTGGTACATTGGGCCGAAAAGAGTTGGAGCCGGTACC
  CCATTCACCGCACTTCAGAATGCGGAACACTTTTATTAAGTGGGGGAAGATCAG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003243 unedited
  CCCCACTTCTGTGNACCGCGCCGCTTTCTANGATCGAGTTTTTTTTTTTTTTTTTTTAAC
  AGGAGGTATCACTGAGCTTATTTTAGTTGCAAAGTGGCATCATATTATTCCATTTAATGA
  AATTCACCTCAAGCCCTTTTTGACATATTAAATATATGGGATATATTTAAGGCAAGAGAA
  GTAAGGCAATCCAAATGAGTGCCCTTTTCCAATCTCAGCACTGTCTTGGTGGAATTGGTG
  ACACTATTCAGATAACCAACTGGAGACCGACAGGATTTGCCATGCATTTGCATCTTGCTA
  GAGTTTGGTTTTTATGAAAGGGCCTATTTTTTTTTAAGTTGACATATTTTGAGTGGAAAC
  ACTCACCCTACCAAATATACTTAAGTTGCAACTCTAAAAGCATAAGGACATTTTCAAATT
  TTCTCTTCTTCAACTGAGAAAATGAATGTGCCAGGTGACATATTATATACTTGTACTTGC
  ATACACATAGAAATATATCACTGTGCAAATTCGTCCTTGACTTTATAACTGAATTTCACC
  TCAAATTATACATTAATTTGCAGAACAAAATATTAGGAATGGGCACAAATCTGTGGTTCC
  TGATTTTGGTCATTTTCAATTTCTGTAGGCCTGTAAGAAATACAAAATTTGCATTAAGAC
  ATTTTGCAGTGGTGTATGCAAGTATGGGAAGAAACAGGAAGCTGATAAGGTCATCAGCAT
  TGGTTTTGGCCCCAGGCACAAGAAAGAATGTTGCCTTAACACTTGTCAGGGTGCAGTCCC
  TGAGGGCAGCACCCATCAAGGGACACATCAGACCCCACAGGTTGTGGCAGCAAGGTCCAG
  AATGTGCATCCAGACAAAGGTGCCAATTANACAGGAGGATCGCTTAGNAAGCCTCAAAGC
  ATT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003243
• Insert Size: 4470 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003243.2, NP_003234.2
• RefSeq Size: 4199 bp
• RefSeq ORF: 2556 bp
• Locus ID: 7049
• UniProt ID: Q03167
• Cytogenetics: 1p22.1
• Domains: zona_pellucida
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Gene Summary: This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
  Transcript Variant: This variant (1) encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.