ADCY3 (NM_004036) Human Untagged Clone

CAT#: SC117621

ADCY3 (untagged)-Human adenylate cyclase 3 (ADCY3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ADCY3
• Synonyms: AC-III; AC3; BMIQ19
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117621 sequence for NM_004036 edited (data generated by NextGen Sequencing)
  ATGCCGAGGAACCAGGGCTTCTCCGAGCCCGAATACTCGGCCGAGTACTCAGCCGAGTAC
  TCCGTCAGCCTGCCCTCCGACCCTGACCGCGGGGTGGGCCGGACCCATGAAATCTCGGTC
  CGGAACTCGGGCTCCTGCCTGTGCCTGCCTCGCTTCATGCGGCTGACTTTCGTGCCGGAG
  TCCTTGGAGAACCTCTACCAGACCTACTTCAAAAGGCAGCGCCACGAGACCCTGCTGGTG
  CTGGTGGTCTTTGCAGCCCTCTTTGACTGCTACGTGGTGGTCATGTGTGCTGTGGTCTTC
  TCCAGCGACAAGCTGGCTTCCCTCGCCGTGGCTGGAATTGGACTGGTGTTGGACATCATC
  CTCTTCGTGCTCTGCAAAAAGGGGCTGCTCCCGGACCGGGTCACCCGCAGAGTGCTGCCC
  TACGTGCTGTGGCTGCTCATAACCGCCCAGATCTTCTCCTACCTGGGCCTGAACTTCGCG
  CGTGCCCACGCGGCTAGTGACACGGTGGGCTGGCAGGTCTTCTTTGTCTTCTCCTTCTTC
  ATCACGCTGCCCCTCAGCCTCAGCCCCATCGTGATCATCTCCGTGGTCTCCTGTGTGGTG
  CACACGTTGGTCCTGGGGGTCACCGTGGCCCAGCAGCAGCAGGAGGAGCTCAAGGGGATG
  CAGCTGCTGCGGGAGATCCTGGCCAACGTCTTCCTCTACCTGTGCGCCATCGCTGTGGGC
  ATCATGTCCTACTACATGGCTGACCGCAAGCACCGCAAGGCCTTCCTGGAGGCCCGCCAG
  TCGCTGGAGGTGAAGATGAACCTGGAAGAGCAGAGCCAGCAGCAGGAGAACCTCATGCTT
  TCCATCCTGCCCAAGCACGTGGCTGACGAGATGCTGAAAGACATGAAGAAAGACGAGAGC
  CAGAAGGACCAGCAGCAGTTCAACACCATGTACATGTACCGTCACGAGAACGTCAGCATC
  CTCTTTGCCGACATCGTGGGCTTTACCCAGCTGTCTTCTGCCTGCAGTGCCCAGGAGCTT
  GTGAAGCTGCTCAACGAGCTCTTTGCCCGCTTTGACAAGCTGGCAGCTAAATACCACCAG
  CTGCGGATTAAGATCCTGGGCGACTGCTACTACTGCATCTGCGGCTTGCCTGACTACCGG
  GAGGACCACGCCGTCTGCTCCATCCTCATGGGGCTGGCCATGGTGGAGGCCATCTCGTAT
  GTGCGGGAGAAGACCAAGACTGGGGTGGACATGCGTGTGGGGGTGCACACGGGCACCGTG
  CTGGGGGGCGTCCTGGGCCAGAAGCGCTGGCAGTACGACGTGTGGTCGACTGATGTCACT
  GTAGCCAACAAGATGGAGGCCGGCGGCATCCCTGGGCGCGTGCACATCTCCCAGAGCACC
  ATGGACTGCCTGAAAGGGGAGTTTGATGTGGAGCCAGGCGATGGGGGCAGCCGCTGTGAT
  TACCTAGAAGAGAAGGGTATTGAAACCTACCTCATCATTGCCTCCAAGCCAGAGGTGAAG
  AAAACAGCCACCCAGAATGGCCTCAATGGCTCGGCCCTGCCCAATGGAGCACCAGCTTCC
  TCAAAGTCCAGCTCCCCTGCCCTCATTGAGACCAAGGAGCCCAACGGGAGTGCCCACAGC
  AGTGGGTCCACGTCGGAGAAGCCCGAGGAGCAGGATGCCCAGGCCGACAACCCCTCATTC
  CCCAACCCACGCCGGAGGCTGCGCCTGCAGGACCTGGCTGACCGAGTGGTGGATGCCTCT
  GAAGATGAGCACGAGCTCAACCAGCTGCTCAACGAGGCCCTGCTTGAGCGAGAGTCCGCC
  CAAGTAGTAAAGAAGAGAAACACCTTCCTCTTGTCCATGCGGTTCATGGACCCCGAGATG
  GAAACCCGCTACTCGGTGGAGAAGGAGAAGCAGAGTGGGGCTGCCTTCAGCTGCTCCTGC
  GTCGTCCTGCTCTGCACGGCCCTGGTCGAGATACTCATCGACCCCTGGCTAATGACAAAC
  TATGTGACCTTCATGGTGGGGGAGATTCTGCTCCTCATCCTGACCATCTGCTCCCTGGCT
  GCCATCTTTCCCCGGGCCTTTCCTAAGAAGCTTGTGGCCTTCTCAACTTGGATTGACCGG
  ACCCGCTGGGCCAGGAACACCTGGGCCATGCTCGCCATCTTCATCCTGGTGATGGCAAAT
  GTCGTGGACATGCTCAGCTGTCTCCAGTACTACACGGGACCCAGCAATGCAACGGCAGGG
  ATGGAGACGGAGGGCAGCTGCCTGGAGAACCCCAAGTATTACAACTATGTGGCCGTGCTG
  TCCCTCATCGCCACCATCATGCTGGTGCAGGTCAGCCACATGGTGAAGCTCACGCTCATG
  CTGCTCGTCGCAGGCGCCGTGGCCACCATCAACCTCTATGCCTGGCGTCCCGTCTTTGAT
  GAATACGACCACAAGCGTTTTCGGGAGCACGACTTACCTATGGTGGCCTTAGAGCAGATG
  CAAGGATTCAACCCTGGGCTCAATGGCACTGACAGGCTGCCCCTGGTGCCTTCCAAGTAC
  TCTATGACGGTGATGGTGTTCCTCATGATGCTCAGCTTCTACTACTTCTCCCGCCACGTA
  GAAAAACTGGCACGGACACTTTTCTTGTGGAAGATTGAGGTCCACGACCAGAAGGAACGT
  GTCTATGAGATGCGACGCTGGAACGAGGCCTTGGTCACCAACATGTTGCCTGAGCACGTG
  GCACGCCATTTCCTGGGGTCCAAGAAGAGAGATGAGGAGCTGTATAGCCAGACGTATGAT
  GAGATTGGAGTCATGTTTGCCTCCCTGCCCAACTTTGCTGACTTCTACACAGAGGAGAGC
  ATCAACAATGGTGGTATTGAGTGTCTGCGTTTCCTCAATGAAATCATCTCGGATTTTGAC
  TCTCTCCTGGACAATCCCAAGTTCCGGGTGATCACCAAGATCAAAACCATTGGCAGCACG
  TATATGGCGGCTTCAGGAGTCACCCCCGATGTCAACACCAATGGCTTTGCCAGCTCCAAC
  AAGGAAGACAAGTCCGAGAGAGAGCGCTGGCAGCACCTGGCTGACCTGGCCGACTTCGCG
  CTGGCCATGAAGGATACGCTCACCAACATCAACAACCAGTCCTTCAATAACTTCATGCTG
  CGCATAGGCATGAACAAAGGCGGGGTTCTGGCTGGGGTCATCGGAGCCCGGAAACCACAC
  TACGACATCTGGGGCAATACAGTCAATGTAGCCAGCAGGATGGAGTCCACGGGGGTCATG
  GGCAACATTCAGGTGGTAGAAGAAACCCAAGTCATCCTCCGAGAGTACGGCTTCCGCTTT
  GTGAGGCGAGGCCCCATCTTTGTGAAGGGGAAGGGGGAGCTGCTGACCTTCTTCTTGAAG
  GGGCGGGATAAGCTAGCCACCTTCCCCAATGGCCCCTCTGTCACACTGCCCCACCAGGTG
  GTGGACAACTCCTGA
  
  Clone variation with respect to NM_004036.3
  1131 c=>t;2226 a=>g;2871 a=>g
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004036 unedited
  GGAAGCACTTGGATTTGTAACCGACTTCACTATAGGGCGGCACGCGCAATTCGGCACGAG
  GGTCCACTTCTCTAGGGCCAGTAGCAGACACCAGCCAGTATGCCGAGGAACCAGGGCTTC
  TCCGAGCCCGATACTCGGCCGAGTACTCAGCCGAGTACTCCGTCAGCCTGCCCTCCGACC
  CTGACCGCGGGGTGGGCCGGACCCATGAAATCTCGGTCCGGTAACTCGGGCTCCTGCCTG
  TGCCTGCCTCGCTTCATGCGGCTGACTTTCGTGCCGGAGTCCTTGGAGAACCTCTACCAG
  ACCTACTTCAAAAGGCAGCGCCACGAGACCCTGCTGGTGCTGGTGGTCTTTGCAGCCCTC
  TTTGACTGCTACGTGGTGGTCATGTGTGCTGTGGTCTTCTCCAGCGACAAGCTGGCTTCC
  CTCGCCGTGGCTGGAATTGGACTGGTGTTGGACATCATCCTCTTCGTGCTCTGCAAAAAG
  GGGCTGCTCCCGGACCGGGTCACCCGCAGAGTGCTGCCCTACGTGCTGTGGCTGCTCATA
  ACCGCCCAGATCTTCTCCTACCTGGGCCTGAACTTCGCGCGTGCCCACGCGGCTAGTGAC
  ACGGTGGGCTGGCAGGTCTTCTTTGTCTTCTCCTTCTTCATCACGCTGCCCCTCAGCCTC
  AGCCCCATCGTGATCATCTCCGTGGTCTCCTGTGTGGTGCACACGTTGGTCCTGGGGGTC
  ACCGTGGCCCAGCAGCAGCAGGAGGAGCTCAAGGGGATGCAGCTGCTGCGGGAGATCCTG
  GCCAACGTCTTCCTCTACCTGTGCGCCATCGCTGTGGGCATCATGTCCTACTACATGGCT
  GACCGCAAGCACCGCAGGCCCTTCCTGGNAGCCCGCCA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004036 unedited
  ATGTACCGCGGCACGCAATCTAGTATCGAGTTTTTTTTTTTTTTTTTTCAAGTTGAATAA
  AGCTTTTAATAAAACAGTCTTGTTCTTTATCAATACCTGTAAATTCTCTTAAAGCAGTAG
  CAAAGGCGACTGTAGCAAGAGCTCAAAAGGCAAGGCAATATCGGAAAGTGTATTTAACAG
  AAGATTAAAAATATAAATGTAGAAGATCTGTTTATATATTTTTCTTTCAAAAATAAATCC
  CCCCTCCCCTGCCAGGTGAAAGGAAATATTGCACTTTCTGTTCTCATGACTAAGGGGACA
  GGAGTTCCAGAAGAACCTTTCAAGATGATCAGGAACACCAGGACGAGGGCCGTCTCACCT
  CACTCGGACCACATGGAGACCTCCCTTCAAAATGGGAGCCATGTCCTGCCCCACCAAGCC
  CTGTCTGAAGTGGAGCTTCCCCGCCTGTGCTCCCTCCACAGTCCCGGAAAGCCCAGCGGC
  AAAGGCAGCTTTGTCCCAGCTCTGCCACCCTCCTGCTCACAGTGGTCAGGGCCCCTCAGG
  GGCAAGGACGGCAGGGATTGGAACGAGGGCTCTGGAAGGACTGTTCAGCCCTATGCCTAA
  GACCCCTATGCTGGGGACACTACAGGCACACAGAGGAATAGCAGGGCCACCCTCAGAGCT
  CACACATCCACGAACAAATGAAGGCTGAGGAGGTTTCTAAACCTATAGTCCATGAGTGTG
  CACTTCATCCAGGAAGGGTCGGACTTCCTTCAGTTTCAAAAATAAATNCTCCCTTCAGTT
  AGNACTGTTGCAGGCTCGAGGCCTTNNCAGAGTGTCCACACCTGTGGGGGCAGGTGACAG
  AGGGCCATGGNGGAATGTGGCTAGCTTATCCCGCCCTCAGAATAAGTCAGCAGCTCCCCC
  TTCCCTCACAAAATGGGCCTNGCCTACAAACGGAGCCGCTCTCGAAGATGACTGGGGTTC
  CTTACACCTGATGTGCCATGTACCCCGGGCTCATCTGTGCTAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004036
• Insert Size: 4470 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_004036.2, NP_004027.1
• RefSeq Size: 4342 bp
• RefSeq ORF: 3435 bp
• Locus ID: 109
• UniProt ID: O60266
• Cytogenetics: 2p23.3
• Domains: CYCc
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Calcium signaling pathway, Chemokine signaling pathway, Dilated cardiomyopathy, Gap junction, GnRH signaling pathway, Melanogenesis, Olfactory transduction, Oocyte meiosis, Progesterone-mediated oocyte maturation, Purine metabolism, Vascular smooth muscle contraction, Vibrio cholerae infection
• Gene Summary: This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
  Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.