Haptoglobin (HP) (NM_005143) Human Untagged Clone

CAT#: SC116954

HP (untagged)-Human haptoglobin (HP), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Haptoglobin
• Synonyms: BP; HP2ALPHA2; HPA1S
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC116954 sequence for NM_005143 edited (data generated by NextGen Sequencing)
  ATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGAC
  TCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCA
  CATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACA
  GAAGGAGATGGAGTATACACCTTAAATGATAAGAAGCAGTGGATAAATAAGGCTGTTGGA
  GATAAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACAT
  GGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAA
  GGAGATGGAGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGAT
  AAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAATCCGGCAAACCCAGTGCAG
  CGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTT
  TCCCACCATAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACG
  GCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCGAAAGACATTGCCCCTACT
  TTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCT
  AACTACTCCCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAG
  AGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAAGTAGGGCGTGTGGGTTAT
  GTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATG
  CTGCCTGTGGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAA
  AAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTGAATGAACACACCTTCTGT
  GCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCC
  GTTCACGACCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGC
  TGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCCATCCAGGACTGGGTTCAG
  AAGACCATAGCTGAGAACTAA
  
  Clone variation with respect to NM_005143.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005143 unedited
  NGTTCAAATTTGTATACGACTCCTATAGGGCGGCCGCGAATCGGCACCAGCAAAACCAAC
  CAANATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGT
  GGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGAT
  TGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCG
  CACAGAAGGAGATGGAGTATACACCTTAAATGATAAGAAGCAGTGGATAAATAAGGCTGT
  TGGAGATAAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGC
  ACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCAC
  AGAAGGAGATGGAGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGG
  AGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAATCCGGCAAACCCAGT
  GCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGAT
  GGTTTCCCACCATAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGAC
  CACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCGAAAGACATTGCCCC
  TACTTTAACACTCTATGTGGNGAAAAAGCAGCTTGTAGAGATTGAGAAAGGNTGTTCTAC
  ACCCTAACTACTCCCCAGTAGATATTGGGGCTCATCAAACTCAACAGAAGGTGTCTGTTA
  TGAGAGAGTGATGCCCATCTGCCTACCCTTCAANATTATGCAGAGTAGGGCGTGTGGGGT
  TATGGTTNCTGGCTGGGGGCGAAAGCCAAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_005143 unedited
  NNNNNNNTTTGACTTTGGACCCGCGGCCGCATNCNANGATCGAGTTTTTTTTTTTTTTTT
  TTTTTTTTGGGGCAAAAAAAACTCTTTATTGATTGACTCAGCAATGCAGGGCTGGCACCC
  ATCAGCTTCAAACCACATCTTATCGCATCCACTCCTGTCCACTCCCGTCCACTTTGCCCT
  CTTCCAGGCTGAAATCTTGCTTTCAGGCAAGGGCTTCCGGCCAGCCTTGCATTAGTTCTC
  AGCTATGGGCTTCTGAACCCAGTCCTGGATGGAAGTCACCTTCACATACACACCATACTC
  AGCCACAGCACAGCTCTTATCAAAGCTTAAGATCCCAGTCGCATACCAGGTGTCCTCCTC
  CAGGTCGTGAACGGCAAAGGCACTGCCCGCATCGCCATAGCAGGTGTCTTCTTGGTACTT
  AGACATGCCAGCACAGAAGGTGTGTTCATTCAGTATGGGCTGCACCCCTACAGGGCTCTT
  CGGTGTCTTCTTTTCGGGGACTGTGCTGCCTTCATAATGCCTTATGCATTGGTCTTGGTC
  AGCCACAGGCAGCATGACATACTTCAGATGGTCAGTAAATTTAAAATTGGCATTTCGCCC
  CCAGCCAGAAACATAACCCACACGCCCTACTTCTGCATAATCCTTTGAAGGTANGCAGAT
  GGGCATCACTCTCTCATTAACAGACACCTTCTGTTTGAGTTTGATGAGCCCAAATCTACC
  TGGNATAGTTAGGNTGTAGAACACCTTCTCATCTCTACAGCTGCTTTTTCCCCCATAGAG
  TGNTAAAGTAGGGGCATGTCTTTCGCTGNTGCATTTTCTGATGGGTCAGAAAGAGATTTA
  GCCGTGTCGCAGCCATGGTCATGATCACGTGCACCTGTGTGAGATATGGTGGAACCATCT
  AACTGCAGGGAGCTGCTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_005143
• Insert Size: 1450 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_005143.2, NP_005134.1
• RefSeq Size: 1433 bp
• RefSeq ORF: 1221 bp
• Locus ID: 3240
• UniProt ID: P00738
• Cytogenetics: 16q22.2
• Domains: CCP, Tryp_SPc
• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane
• Gene Summary: This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).