NR2F6 (NM_005234) Human Untagged Clone

CAT#: SC116862

NR2F6 (untagged)-Human nuclear receptor subfamily 2, group F, member 6 (NR2F6)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NR2F6
• Synonyms: EAR-2; EAR2; ERBAL2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_005234 edited
  GGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGAATTTTG
  TAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGCCTGGAACCGGCCCGACCA
  GTTCCGCCCGGGCGCGAGGACCGGCCGCAGGAAGTTGCTGCAAAACTTTTTTGGGGGGTG
  CAGCCCGTGCCCCCCGCGCGCCGGGGCCGAATGCGCGCCGCGTAGGGTCCCCCGGGCCGA
  GAGGGGTGCCCGGAGGGAAGAGCGCGGTGGGGGCGCCCCGGCCCCGCTGCCCTGGGGCTA
  TGGCCATGGTGACCGGCGGCTGGGGCGGCCCCGGCGGCGACACGAACGGCGTGGACAAGG
  CGGGCGGCTACCCGCGCGCGGCCGAGGACGACTCGGCCTCGCCCCCCGGTGCCGCCAGCG
  ACGCCGAGCCGGGCGACGAGGAGCGGCCGGGGCTGCAGGTGGACTGCGTGGTGTGCGGGG
  ACAAGTCGAGCGGCAAGCATTACGGTGTCTTCACCTGCGAGGGCTGCAAGAGCTTTTTCA
  AGCGAAGCATCCGCCGCAACCTCAGCTACACCTGCCGGTCCAACCGTGACTGCCAGATCG
  ACCAGCACCACCGGAACCAGTGCCAGTACTGCCGTCTCAAGAAGTGCTTCCGGGTGGGCA
  TGAGGAAGGAGGCGGTGCAGCGCGGCCGCATCCCGCACTCGCTGCCTGGTGCCGTGGCCG
  CCTCCTCGGGCAGCCCCCCGGGCTCGGCGCTGGCGGCAGTGGCGAGCGGCGGAGACCTCT
  TCCCGGGGCAGCCGGTGTCCGAACTGATCGCGCAGCTGCTGCGCGCTGAGCCCTACCCTG
  CGGCGGCCGGACGCTTCGGCGCAGGGGGCGGCGCGGCGGGCGCGGTGCTGGGCATCGACA
  ACGTGTGCGAGCTGGCGGCGCGGCTGCTCTTCAGCACCGTGGAGTGGGCGCGCCACGCGC
  CCTTCTTCCCCGAGCTGCCGGTGGCCGACCAGGTGGCGCTGCTGCGCCTGAGCTGGAGCG
  AGCTCTTCGTGCTGAACGCGGCGCAGGCGGCGCTGCCCCTGCACACGGCGCCGCTACTGG
  CCGCCGCCGGCCTCCACGCCGCGCCTATGGCCGCCGAGCGCGCCGTGGCTTTCATGGACC
  AGGTGCGCGCCTTCCAGGAGCAGGTGGACAAGCTGGGCCGCCTGCAGGTCGACTCGGCCG
  AGTATGGCTGCCTCAAGGCCATCGCGCTCTTCACGCCCGACGCCTGTGGCCTCTCAGACC
  CGGCCCACGTTGAGAGCCTGCAGGAGAAGGCGCAGGTGGCCCTCACCGAGTATGTGCGGG
  CGCAGTACCCGTCCCAGCCCCAGCGCTTCGGGCGCCTGCTGCTGCGGCTCCCCGCCCTGC
  GCGCGGTCCCTGCCTCCCTCATCTCCCAGCTGTTCTTCATGCGCCTGGTGGGGAAGACGC
  CCATTGAGACACTGATCAGAGACATGCTGCTGTCGGGGAGTACCTTCAACTGGCCCTACG
  GCTCGGGCCAGTGACCATGACGGGGCCACGTGTGCTGTGGCCAGGCCTGCAGACAGACCT
  CAAGGGACAGGGAATGCTGAGGCCTCGAGGGGCCTCCCGGGGCCCAGGACTCTGGCTTCT
  CTCCTCAGACTTCTATTTTTTAAAGACTGTGAAATGTTTGTCTTTTCTGTTTTTTAAATG
  ATCATGAAACCAAAAAGAGACTGATCATCCAGGCCTCAGCCTCATCCTCCCCAGGACCCC
  TGTCCAGGATGGAGGGTCCAATCCTAGGACAGCCTTGTTCCTCAGCACCCCTAGCATGAA
  CTTGTGGGATGGTGGGGTTGGCTTCCCTGGCATGATGGACAAAGGCCTGGCGTCGGCCAG
  AGGGGCTGCTCCAGTGGGCAGGGGTAGCTAGCGTGTGCCAGGCAGATCCTCTGGACACGT
  AACCTATGTCAGACACTACATGATGACTCAAGGCCAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005234 unedited
  TTATATTTGTNAATACGCACTCACTTATAGGGCGGCCGCGAATTCGCACGAGCCTGGAAC
  CGGCCCGACCAGTTCCGCCCGGGCGCGAGGACCGGCCGCAGGAAGTTGCTGCAAAACTTT
  TTTGGGGGGTGCAGCCCGTGCCCCCCGCGCGCCGGGGCCGAATGCGCGCCGCGTAGGGTC
  CCCCGGGCCGAGAGGGGTGCCCGGAGGGAAGAGCGCGGTGGGGGCGCCCCGGCCCCGCTG
  CCCTGGGGCTATGGCCATGGTGACCGGCGGCTGGGGCGGCCCCGGCGGCGACACGAACGG
  CGTGGACAAGGCGGGCGGCTACCCGCGCGCGGCCGAGGACGACTCGGCCTCGCCCCCCGG
  TGCCGCCAGCGACGCCGAGCCGGGCGACGAGGAGCGGCCGGGGCTGCAGGTGGACTGCGT
  GGTGTGCGGNGACAAGTCGAGCGGCAAGCATTACGGTGTCTTCACCTGCGAGGGCTGCAA
  GAGCTTTTTCAAGCGAAGCATCCGCCGCAACCTCAGCTACACCTGCCGGTCCAACCGTGA
  CTGCCAGATCGACCAGCACCACCGGAACCAGTGCCAGTACTGCCGTCTCAAGAAGTGCTT
  CCGGGTGGGCATGAAGAAAGANGCGGTGCAGCGCGGCCGCATCCCGCACTCGCTGCCTGG
  TGCCGTGGNCGCCTTCTCGGNCAGCCCCCCGGGCTTCGCGCTTGCGCCATTGCGAGCGGC
  GGAGACCTCTTCCCGGNGCAGCCCGTGTCCGAACTGATCGCGCAGCTGCTGCGCGCTGAC
  CCCTACCTGCGGCGGCCGAACCCTTCGCCCAGGNGGCGGCCCGATGGCCCCGTGCTGGCA
  TCNACACGTGTGCGAGCTGGCGGCGCGCTGCTCTTCACAACGTGATTGGGCGCGCACGCG
  CCCTTTTTCCCGACTGCCGTGGCCGACAAGTGCGCTGTTCCCTGACTGTACAACTCTTTG
  CTGACCG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_005234 unedited
  AAGTGTGGGCAAGTCTTTTTTTGGCCTTGGATCTCATGTAGTGTCTGACATAGGTTACGT
  GTCCAGAGGATCTGCCTGGCACACGCTAGCTACCCCTGCCCACTGGAGCAGCCCCTCTGG
  CCGACGCCAGGCCTTTGTCCATCATGCCAGGGAAGCCAACCCCACCATCCCACAAGTTCA
  TGCTAGGGGTGCTGAGGAACAAGGCTGTCCTAGGATTGGACCCTCCATCCTGGACAGGGG
  TCCTGGGGAGGATGAGGCTGAGGCCTGGATGATCAGTCTCTTTTTGGTTTCATGATCATT
  TAAAAAACAGAAAAGACAAACATTTCACAGTCTTTAAAAAATAGAAGTCTGAGGAGAGAA
  GCCAGAGTCCTGGGCCCCGGGAGGCCCCTCGAGGCCTCAGCATTCCCTGTCCCTTGAGGT
  CTGTCTGCAGGCCTGGCCACAGCACACGTGGCCCCGTCATGGTCACTGGCCCGAGCCGTA
  NGGCCAGTTGAAGGTACTCCCCGACAGCAGCATGTCTCTGATCAGTGTCTCAATGGGCGT
  CTTCCCCACCAGGCGCATGAAGAACAGCTGGGAGATGAGGGAGGCAGGGACCGCGCCGCA
  GGCGGGGAGCCGCAGCAGCAGGCGCCCGAAGCGCTGGGGCTTGGGACGGGTACTGCGCCC
  GCACATACTCGGTGAGGGCCACCTGCGCCTTCTCCTGCAGGCTCTCAACGTGGGGCGGGT
  TCTGAGAGGGCACAGCCCGTTCGCCGCGAAAAACCGCAAGGCCCTTGAAGGCAGCATACT
  CGGCCCGGTCGACCTGAAGGCGGCCCATTTGTTCCCCTGCTCCGGGAAGCCGCCCCCTGG
  TCCAGGAAAGCCCGGGCGCTCTGCGGCCTAGCCCCGCGTGGAGCCCGCGGTGGCCATAAC
  CGGCCCTGGTGCCGGGCCCCCCC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_005234
• Insert Size: 1980 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_005234.3, NP_005225.2
• RefSeq Size: 1804 bp
• RefSeq ORF: 1215 bp
• Locus ID: 2063
• UniProt ID: P10588
• Cytogenetics: 19p13.11
• Domains: HOLI, zf-C4
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Gene Summary: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).[UniProtKB/Swiss-Prot Function]