PDIA6 (NM_005742) Human Untagged Clone

CAT#: SC116546

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PDIA6 (untagged)-Human protein disulfide isomerase family A, member 6 (PDIA6)



  "NM_005742" in other vectors (7)

Reconstitution Protocol

USD 686.00


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Size
    • 10 ug


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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PDIA6
Synonyms ERP5; P5; TXNDC7
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC116546 sequence for NM_005742 edited (data generated by NextGen Sequencing)
ATGGCTCTCCTGGTGCTCGGTCTGGTGAGCTGTACCTTCTTTCTGGCAGTGAATGGTCTG
TATTCCTCTAGTGATGATGTGATCGAATTAACTCCATCAAATTTCAACCGAGAAGTTATT
CAGAGTGATAGTTTGTGGCTTGTAGAATTCTATGCTCCATGGTGTGGTCACTGTCAAAGA
TTAACACCAGAATGGAAGAAAGCAGCAACTGCATTAAAAGATGTTGTCAAAGTTGGTGCA
GTTGATGCAGATAAGCATCATTCCCTAGGAGGTCAGTATGGTGTTCAGGGATTTCCTACC
ATTAAGATTTTTGGATCCAACAAAAACAGACCAGAAGATTACCAAGGTGGCAGAACTGGT
GAAGCCATTGTAGATGCTGCGCTGAGTGCTCTGCGCCAGCTCGTGAAGGATCGCCTCGGG
GGACGAAGCGGAGGATACAGTTCTGGAAAACAAGGCAGAAGTGATAGTTCAAGTAAGAAG
GATGTGATTGAGCTGACAGACGACAGCTTTGATAAGAATGTTCTGGACAGTGAAGATGTT
TGGATGGTTGAGTTCTATGCTCCTTGGTGTGGACACTGCAAAAACCTAGAGCCAGAGTGG
GCTGCCGCAGCTTCAGAAGTAAAAGAGCAGACGAAAGGAAGAGTGAAACTGGCAGCTGTG
GATGCTACAGTCAATCAGGTTCTGGCCTCCCGATACGGGATTAGAGGATTTCCTACAATC
AAGATATTTCAGAAAGGCGAGTCTCCTGTGGATTATGACGGTGGGCGGACAAGATCCGAC
ATCGTGTCCCGGGCCCTTGATTTGTTTTCTGATAACGCCCCACCTCCTGAGCTGCTTGAG
ATTATCAACGAGGACATTGCCAAGAGGACGTGTGAGGAGCACCAGCTCTGTGTTGTGGCT
GTGCTGCCCCATATCCTTGATACTGGAGCTGCAGGCAGAAATTCTTATCTGGAAGTTCTT
CTGAAGTTGGCAGACAAATACAAAAAGAAAATGTGGGGGTGGCTGTGGACAGAAGCTGGA
GCCCAGTCTGAACTTGAGACCGCGTTGGGGATTGGAGGGTTTGGGTACCCCGCCATGGCC
GCCATCAATGCACGCAAGATGAAATTTGCTCTGCTAAAAGGCTCCTTCAGTGAGCAAGGC
ATCAACGAGTTTCTCAGGGAGCTCTCTTTTGGGCGTGGCTCCACGGCACCTGTAGGAGGC
GGGGCTTTCCCTACCATCGTTGAGAGAGAGCCTTGGGACGGCAGGGATGGCGAGCTTCCC
GTGGAGGATGACATTGACCTCAGTGATGTGGAGCTTGATGACTTAGGGAAAGATGAGTTG
TGA

Clone variation with respect to NM_005742.2
99 g=>a;426 g=>a;641 a=>g
>OriGene 5' read for NM_005742 unedited
NNGGGGAAACNNNNNNCCACCCCGCNGGGTTCAGAATTGTATACGACTCATATAGGCGGC
CGCGAAATCGGCACCAGCCGGNCTGGCCTGGGGCGGGACGTGGGCGCGGGGGCGCGGCGT
GCGGCACGCTGCAGGGCTGAAGCGGCGGCGGCGGTGGGGACTGCACGTAGCCCGGCGCTC
GGCATGGCTCTCCTGGTGCTCGGTCTGGTGAGCTGTACCTTCTTTCTGGCAGTGAATGGT
CTGTATTCCTCTAGTGATGATGTGATCGAATTAACTCCATCAAATTTCAACCGAGAAGTT
ATTCAGAGTGATAGTTTGTGGCTTGTAGAATTCTATGCTCCATGGTGTGGTCACTGTCAA
AGATTAACACCAGAATGGAAGAAAGCAGCAACTGCATTAAAAGATGTTGTCAAAGTTGGT
GCAGTTGATGCAGATAAGCATCATTCCCTAGGAGGTCAGTATGGTGTTCAGGGATTTCCT
ACCATTAAGATTTTTGGATCCAACAAAAACAGACCAGAAGATTACCAAGGTGGCAGAACT
GGTGAAGCCATTGTAGATGCTGCGCTGAGTGCTCTGCGCCAGCTCGTGAAGGATCGCCTC
GGGGGACGAAGCGGAGGATACAGTTCTGGAAAACAAGGCAGAAGTGATAGTTCAAGTAAG
AAGGATGTGATTGAGCTGACAGACGACAGCTNTGATAAGAATGTTCTGGACAGTGAAGAT
GTTTGGATGGNNTGAGTCTATGCTNCTTTGTGTGGACACTGCAAAAACCTANAGCCCAGA
GTGGGCTGCCGCAGCTTCAGAAGTAAAAGAGCAGACGAAAGGAAGAAGTGAACTGGCAGC
TGTGGATGCTACAGTCAAATCAGGTCTGGCCTCCCGATACGGNNATAAAGGATTNCTACA
TCAAGAAATTNCAAAAGGCCAGTCTCCTGTGGATATGACCGTGGGCGCACAGAAA
>OriGene 3' read for NM_005742 unedited
NNNTTTTACTCTGNNACCGCGGCCGCATNCTANGATCGAGTTTTTTTTTTTTTTTTTTTT
TAGTGACAGTTGTATTTATTTTTTTAAGTTACAATAAAATGCTCTCAAGTCCTTTGAATG
TTCCAACAAATTCAAAACTTCATTTTCTGAATGTTTTACATAAATGCGAACTACCTGTTC
GCATTGGTAACCTGCTGCTGTATTTCATGTCTTAACGGCTATTTTGAGGTTCATTAACAA
CATAGAAAGCCTTGAACTGTATAACCAGCTAGATTCCTTAATAATTAGTCACTAGAGACA
GCCCAAAGACAAATATTGGGCAGGAAATCAGTTCTCACTGAGCCCGGTTTCCATGTAAAA
TCTCTGTTGTGGTGGGCATAGGTGGCACCATCTAAAGAAAAGAGGTCTTGTTTTTTGTTT
AAAAAAGTTTGTGGGGAGGAAAGACATCTGTGTATCACTTCAAAATATTGATTTACTGCT
AAACATCACTCTGAATTTATGATGTGGATACTAACTTCATACATTTATCGGCATTGTCCA
AAATATTTTATTCTTTAATGGAAAAAGCCATTAATATTCAAATGAAGGGATCACATTAAA
AAAAACCCATACATAAGAAACAGCCTCCAAGAACATTCAAGCAGCAGTCAGAGAGAAAAA
TGTTTCGACAGCCAAGTTTTCTTCAAAATATTATGTGACAGAATACGACTCAATTCACCG
GCTACAACAATTCATAGAATTTTTCAATGTTTTCTTGAGATGCAAAAGNTCACTGTTGCA
GTGTTTTCAAATGACCCAATCAGTACTACTTCTTGGTTAAAAGCCACTGNTAGAGTCATC
TGAGTGTANAGGATGTCCCTTCACTGCTGGAAAAATCCCTGGNCTCCAAAGAAAGAAATG
GTCTGAAGCCTCTGNTGTGGCTCTTACAACTCAC
Restriction Sites NotI-NotI     
ACCN NM_005742
Insert Size 2380 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_005742.2, NP_005733.1
RefSeq Size 2344 bp
RefSeq ORF 1323 bp
Locus ID 10130
UniProt ID Q15084
Cytogenetics 2p25.1
Domains thiored
Protein Families Druggable Genome
Gene Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Transcript Variant: This variant (4) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.

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