MALT1 (NM_006785) Human Untagged Clone

CAT#: SC115846

MALT1 (untagged)-Human mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MALT1
• Synonyms: IMD12; MLT; MLT1; PCASP1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_006785, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTCGCTGTTGGGGGACCCGCTACAGGCCCTGCCGCCCTCGGCCGCCCCCACGGGGCCGCTGCTCGCCC
  CTCCGGCCGGCGCGACCCTCAACCGCCTGCGGGAGCCGCTGCTGCGGAGGCTCAGCGAGCTCCTGGATCA
  GGCGCCCGAGGGCCGGGGCTGGAGGAGACTGGCGGAGCTGGCGGGGAGTCGCGGGCGCCTCCGCCTCAGT
  TGCCTAGACCTGGAGCAGTGTTCTCTTAAGGTACTGGAGCCTGAAGGAAGCCCCAGCCTGTGTCTGCTGA
  AGTTAATGGGTGAAAAAGGTTGCACAGTCACAGAATTGAGTGATTTCCTGCAGGCTATGGAACACACTGA
  AGTTCTTCAGCTTCTCAGCCCCCCAGGAATAAAGATTACTGTAAACCCAGAGTCAAAGGCAGTCTTGGCT
  GGACAGTTTGTGAAACTGTGTTGCCGGGCAACTGGACATCCTTTTGTTCAATATCAGTGGTTCAAAATGA
  ATAAAGAGATTCCAAATGGAAATACATCAGAGCTTATTTTTAATGCAGTGCATGTAAAAGATGCAGGCTT
  TTATGTCTGTCGAGTTAATAACAATTTCACCTTTGAATTCAGCCAGTGGTCACAGCTGGATGTTTGCGAC
  ATCCCAGAGAGCTTCCAGAGAAGTGTTGATGGCGTCTCTGAATCCAAGTTGCAAATCTGTGTTGAACCAA
  CTTCCCAAAAGCTGATGCCAGGCAGCACATTGGTTTTACAGTGTGTTGCTGTTGGAAGCCCTATTCCTCA
  CTACCAGTGGTTCAAAAATGAATTACCATTAACACATGAGACCAAAAAGCTATACATGGTGCCTTATGTG
  GATTTGGAACACCAAGGAACCTACTGGTGTCATGTATATAATGATCGAGACAGTCAAGATAGCAAGAAGG
  TAGAAATCATCATAGGAAGAACAGATGAGGCAGTGGAGTGCACTGAAGATGAATTAAATAATCTTGGTCA
  TCCTGATAATAAAGAGCAAACAACTGACCAGCCTTTGGCGAAGGACAAGGTTGCCCTTTTGATAGGAAAT
  ATGAATTACCGGGAGCACCCCAAGCTCAAAGCTCCTTTGGTGGATGTGTACGAATTGACTAACTTACTGA
  GACAGCTGGACTTCAAAGTGGTTTCACTGTTGGATCTTACTGAATATGAGATGCGTAATGCTGTGGATGA
  GTTTTTACTCCTTTTAGACAAGGGAGTATATGGGTTATTATATTATGCAGGACATGGTTATGAAAATTTT
  GGGAACAGCTTCATGGTCCCCGTTGATGCTCCAAATCCATATAGGTCTGAAAATTGTCTGTGTGTACAAA
  ATATACTGAAATTGATGCAAGAAAAAGAAACTGGACTTAATGTGTTCTTATTGGATATGTGTAGGAAAAG
  AAATGACTACGATGATACCATTCCAATCTTGGATGCACTAAAAGTCACCGCCAATATTGTGTTTGGATAT
  GCCACGTGTCAAGGAGCAGAAGCTTTTGAAATCCAGCATTCTGGATTGGCAAATGGAATCTTTATGAAAT
  TTTTAAAAGACAGATTATTAGAAGATAAGAAAATCACTGTGTTACTGGATGAAGTTGCAGAAGATATGGG
  TAAGTGTCACCTTACCAAAGGCAAACAGGCTCTAGAGATTCGAAGTAGTTTATCTGAGAAGAGAGCACTT
  ACTGATCCAATACAGGGAACAGAATATTCTGCTGAATCTCTTGTGCGGAATCTACAGTGGGCCAAGGCTC
  ATGAACTTCCAGAAAGTATGTGTCTTAAGTTTGACTGTGGTGTTCAGATTCAATTAGGATTTGCAGCTGA
  GTTTTCCAATGTCATGATCATCTATACAAGTATAGTTTACAAACCACCGGAGATAATAATGTGTGATGCC
  TACGTTACTGATTTTCCACTTGATCTAGATATTGATCCAAAAGATGCAAATAAAGGCACACCTGAAGAAA
  CTGGCAGCTACTTGGTATCAAAGGATCTTCCCAAGCATTGCCTCTATACCAGACTCAGTTCACTGCAAAA
  ATTAAAGGAACATCTAGTCTTCACAGTATGTTTATCATATCAGTACTCAGGATTGGAAGATACTGTAGAG
  GACAAGCAGGAAGTGAATGTTGGGAAACCTCTCATTGCTAAATTAGACATGCATCGAGGTTTGGGAAGGA
  AGACTTGCTTTCAAACTTGTCTTATGTCTAATGGTCCTTACCAGAGTTCTGCAGCCACCTCAGGAGGAGC
  AGGGCATTATCACTCATTGCAAGACCCATTCCATGGTGTTTACCATTCACATCCTGGTAATCCAAGTAAT
  GTTACACCAGCAGATAGCTGTCATTGCAGCCGGACTCCAGATGCATTTATTTCAAGTTTCGCTCACCATG
  CTTCATGTCATTTTAGTAGAAGTAATGTGCCAGTAGAGACAACTGATGAAATACCATTTAGTTTCTCTGA
  CAGGCTCAGAATTTCTGAAAAATGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006785 unedited
  TAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGGCGGGGAGCGGAGCTTC
  CTCCTCTGAGGGCCGTGCCGCGCTGCCAGATTTGTTCTTCCGCCCCTGCCTCCGCGGCTC
  GGAGGCGAGCGGAAGGTGCCCCGGGGCCGAGGCCCGTGACGGGGCGGGCGGGAGCCCCGG
  CAGTCCGGGGTCGCCGGCGAGGGCCATGTCGCTGTTGGGGGACCCGCTACAGGCCCTGCC
  GCCCTCGGCCGCCCCCACGGGGCCGCTGCTCGCCCCTCCGGCCGGCGCGACCCTCAACCG
  CCTGCGGGAGCCGCTGCTGCGGAGGCTCAGCGAGCTCCTGGATCAGGCGCCCGAGGGCCG
  GGGCTGGAGGAGACTGGCGGAGCTGGCGGGGAGTCGCGGGCGCCTCCGCCTCAGTTGCCT
  AGACCTGGAGCAGTGTTCTCTTAAGGTACTGGAGCCTGAAGGAAGCCCCAGCCTGTGTCT
  GCTGAAGTTAATGGGTGAAAAAGGTTGCACAGTCACAGAATTGAGTGATTTCCTGCAGGC
  TATGGAACACACTGAAGTTCTTCAGCTTCTCAGCCCCCCAGGAATAAAGATTACTGGTAA
  CCCAGAGTCAAAGGCAGTCTTGGCTGGACAGTTTGTGAAACTGTGTTGCCGGGCAACTGG
  ACATCCTTTTGTTCATATCAGTGGTTCANAATGAATAAAGAGATTCCAAATGGAAATACA
  TCAGAGCTTATTTTTTATGCAGTGCATGTAAAAGATGCANGCTTTTNATAGTCTGTCGAG
  TTAATAACAATTTCACCTTTTGATCAGCCAGTGGTCACAGCTGGNATGTTGCGACATCCA
  GAGAGCTCCAGAGAGTGGGTTGTTGCGGTTTCTGAATCCAGGTGCAAATCTGTGTTGAAC
  CACCTCTCA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006785 unedited
  CGACAAATAAGCCCTCTGTTAATATTTATATATATATCAATATATTTCACTCTATCTACA
  AACATAACACTTATCTCAGAACCTGTCAGGAAGGCAGTTGTGTAGTGGAAAAAATACTGG
  AATAGATTTCTGGAGGTCTCAGTTCTGGTGCCAGCTCTAACTTAGATGCCTTTCTGTGTT
  TCTTCCATGGATAAAATTAGGTTATGCCTGGTGATCGGCAAGGTTCTTTCTGGTGTTAAA
  AATACAATGACTTATTCTACAATAATGCCATTCCCATTGCTCTTACTTCAGAGTGGTCAC
  AATGAAAATATTTTGTTATATACATATAAACATACACACCTCCATACTTCATTTGTATAG
  AACTATTCAACCAATTCACAAAATCTTAGAAAGAGGAAGTCTGTAATTAAATAATGTAAT
  TTCAACATCTCAAAGTCCTGAAGTTTGCTATGAAACAGTTACTACTATTCTTTCTCTACA
  TATACAAATTTGCCTTTTCACAATGTCTCACTTTATGTAAGTGCAGTACTATTTCACAGG
  CATCTAAAATTATGCTAACTTTCAAAAACAAGGAGGTCATTTTTCAGAAATTCTGAGCCT
  GTCAGAGAAACTAAATGGTATTTCATCAGTTGTCTCTACTGGCACATTACTTCTACTAAA
  ATGACATGAAGCATGGTGAGCGAAACTTGAAATAAATGCATCTGGAGTCCGGCTGCAATG
  ACAGCTATCTGCTGGTGTAACATTACTTGGATTACCAGGATGTGAATGGTAAACACCATG
  GAATGGGTCTTGCAATGAGTGATAATGCCCTGCTCCTCCTGAGGTGGCTGCAGAACTCTG
  GTAAGGACCATTNAGACATAGACAAGTNTGAAAAGCAGTCTTTCCTTCCAAACCTCGATG
  CATGTCTAATTTAGCAATGAGAGGTTNCCCAACATTCACTTNCTGCTTGNCCTCTCAGTA
  TCTTCCATCCTGAGTACTGAATGATAAAATACTGTGAGACTAGATGTCCTTCATTTTGCA
  GTGACTGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006785
• Insert Size: 3670 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_006785.2, NP_006776.1
• RefSeq Size: 5029 bp
• RefSeq ORF: 2475 bp
• Locus ID: 10892
• UniProt ID: Q9UDY8
• Cytogenetics: 18q21.32
• Domains: DEATH, ig, IGc2, IG
• Protein Families: Druggable Genome, Protease
• Protein Pathways: B cell receptor signaling pathway, T cell receptor signaling pathway
• Gene Summary: This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018]
  Transcript Variant: This variant (1) encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.