CLN6 (NM_017882) Human Untagged Clone

CAT#: SC113923

CLN6 (untagged)-Human ceroid-lipofuscinosis, neuronal 6, late infantile, variant (CLN6)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CLN6
• Synonyms: CLN4A; HsT18960; nclf
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_017882 edited
  GAATTCGGCACGAGGGGGCAGCCGAGCTGAACCGGTCTCTTCCTCGGAAAGGCAGGGCCG
  AGGGGCCTGCGGGGCAGCCATGGAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGG
  CGGCCCAGGCGCGCAGCTGGGCGCCTCCTTCCTGCAGGCCAGGCATGGCTCTGTGAGCGC
  TGATGAGGCTGCCCGCACGGCTCCCTTCCACCTCGACCTCTGGTTCTACTTCACACTGCA
  GAACTGGGTTCTGGACTTTGGGCGTCCCATTGCCATGCTGGTATTCCCTCTCGAGTGGTT
  TCCACTCAACAAGCCCAGTGTTGGGGACTACTTCCACATGGCCTACAACGTCATCACGCC
  CTTTCTCTTGCTCAAGCTCATCGAGCGGTCCCCCCGCACCCTGCCACGCTCCATCACGTA
  CGTGAGCATCATCATCTTCATCATGGGTGCCAGCATCCACCTGGTGGGTGACTCTGTCAA
  CCACCGCCTGCTCTTCAGTGGCTACCAGCACCACCTGTCTGTCCGTGAGAACCCCATCAT
  CAAGAATCTCAAGCCGGAGACGCTGATCGACTCCTTTGAGCTGCTCTACTATTATGATGA
  GTACCTGGGTCACTGCATGTGGTACATCCCCTTCTTCCTCATCCTCTTCATGTACTTCAG
  CGGCTGCTTTACTGCCTCTAAAGCTGAGAGCTTGATTCCAGGGCCTGCCCTGCTCCTGGT
  GGCACCCAGTGGCCTGTACTACTGGTACCTGGTCACCGAGGGCCAGATCTTCATCCTCTT
  CATCTTCACCTTCTTCGCCATGCTGGCCCTCGTCCTGCACCAGAAGCGCAAGCGCCTCTT
  CCTGGACAGCAACGGCCTCTTCCTCTTCTCCTCCTTCGCACTGACCCTCTTGCTTGTGGC
  GCTCTGGGTCGCCTGGCTGTGGAATGACCCTGTTCTCAGGAAGAAGTACCCGGGTGTCAT
  CTACGTCCCTGAGCCCTGGGCTTTCTACACCCTTCACGTCAGCAGTCGGCACTGAGTCCC
  TGGCACCAGGCTCTGGCGCTCTGCTGGGTGGGAGGGTGGGCCATGGAGGGCATCTGAATA
  CAGGAGTAGGGGGGGTGTGGGTGTGTAACCAGAGACCGAGAGCATGAGTGGGGTGTGCCT
  CGTGTGCGTGGATTCGTGTGTGTGTGTGTGTCTTGTATATGTGTGCGCAGAGTGCATCAT
  TTTCAGACTCTACTATTTCCGTCAAGTTTCTGTTTGATTTGGATCATCTCAGGATCGGAT
  TCTGTTTTAGAGTGTTTCTGGGCCAGGATCCGGGCCCCTGCCCTCCTCTGCACCTGACCA
  CACTCCCTACTCAGGGCTAGTCTGTTCTTCCCGGACATCTTCTGGTAGCCGTGCAGGAGA
  GGGCTGGGTGGGGCAGAGGCCAGGAGGGGACCTGGTGTGTCACCTGCCCACCACCTGGCT
  CATCCCTCAGGCCCACCCTGACCCTACATTACATAGGTTACGTCAGCCTACTGTGGCTGT
  TGAGCAAAGCATTTCTCCTTTCTGGGCCTCATTTGCACTAGATGGGCCTGTGGTCCAAAG
  TAGGTCAGTAGGTTGGGGTTGCTGACACCCCTTGGGTGCAGCTTTGGGACAGATGAGTGG
  CTCTGTCCTGTCACTGCCCTCTCCCTGCCTGGGGGCTATGTGCACTCCAGACCCCTGCCC
  AGGCTCAGGCCCATGAGGTATGGAGACACCCTGGCCCCCAGGAGCTGGAGGCACCGCCCA
  CTCCCCTGGCATTCCAGCTTTGCAGGTGACCCTCCTCTACCCAAAGCTCTGTCCCCCTGC
  TCCCACTCCAGAAGAACTGCGGCACGTGCTTCGGGCAGCCTAGCCACAGGCTTTGAGCGC
  CTGCATTCCTGGGGGCTGGAGGGTGGGGTGCCAAAGGCCCTGAGCAAAAGCCAGAGCTCC
  TCTCATCAAAGCCTTTACAAGGTGCTGGGCCCAGAGGCTTTGCCTTGACAGAGTGGCCCA
  GGGTTTCAAGGGAGGAGGAACCTCCCCCTACCTAGGACCCTTCCTGTGGGGGGTCTACAG
  AGTCAGGGACAGAAGGGAAGGGACCCACAGGAAGTCACAGTGGTGCCCAGGGATGTGTCA
  GCCCCCAGCCACGGGGACGCGGGATTCAAGAATGAAGTAAATACAGTCACAGCCCCAAAA
  AAAAAAAAAAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_017882 unedited
  GGGTGTTTAGATTTGTATACGACTCACTATAGGCGGCCGCGAATCGGCACGAGGGGGCAG
  CCGAGCTGAACCGGTCTCTTCCTCGGAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATG
  GAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGGCGGCCCAGGCGCGCAGCTGGGC
  GCCTCCTTCCTGCAGGCCAGGCATGGCTCTGTGAGCGCTGATGAGGCTGCCCGCACGGCT
  CCCTTCCACCTCGACCTCTGGTTCTACTTCACACTGCAGAACTGGGTTCTGGACTTTGGG
  CGTCCCATTGCCATGCTGGTATTCCCTCTCGAGTGGTTTCCACTCAACAAGCCCAGTGTT
  GGGGACTACTTCCACATGGCCTACAACGTCATCACGCCCTTTCTCTTGCTCAAGCTCATC
  GAGCGGTCCCCCCGCACCCTGCCACGCTCCATCACGTACGTGAGCATCATCATCTTCATC
  ATGGGTGCCAGCATCCACCTGGTGGGTGACTCTGTCAACCACCGCCTGCTCTTCAGTGGC
  TACCAGCACCACCTGTCTGTCCGTGAGAACCCCATCATCAAGAATCTCAAGCCGGAGACG
  CTGATCGACTCCTTTGAGCTGCTCTACTATTATGATGAGTACCTGGGTCACTGCATGTGG
  TACATCCCCTTCTTCCTCATCCTCTTCATGTACTTCAGCGGCTGCTTTACTGCCTCTAAA
  GCTGAGAGCTTGATTCCAGGGCCTGCCCTGCTCCTGGTGGCACCCAGTGGCCTGTACTAC
  TGGTACCTGGTCACCGNAGGCCAGATCTTCATCCTCTTCATCTTCACCTTCTTCGCCATG
  CTGGCCCTCGTCCTGCACCAAAAGCGCAAGCGCCTCTTCCTG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_017882 unedited
  GTACCAAAGCGGCNCTCNAGGTNCGAGAAAAAATCTTTTTTTTTTGGGGCTGTGACTGTT
  TTTACTTCATTCTTGAATCCCGCGTCCCCGTGGCTGGGGGCTGACACATCCCTGGGCACC
  ACTGTGACTTCCTGTGGGTCCCTTCCCTTCTGTCCCTGACTCTGTAGACCCCCCACAGGA
  AGGGTCCTAGGTAGGGGGAGGGTCCTTCTCCTCNTAAACCCTGGGCCACTCTGTCAAGGC
  AAAGCCTCTGGGCCCAGCACCTTGTAAAGGCTTTGATGAGAGGAGCTCTGGCTTTTGCTC
  AGGGCCTTTGGCACCCCACCCTCCAGCCCCCAGGAATGCAGGCGCTCAAAGCCTGTGGCT
  AGGCTGCCCGAAGCACGTGCCGCAGTTCTTCTGGAGTGGGAGCAGGGGGACAGAGCTTTG
  GGTAGAGGAGGGTCACCTGCAAAGCTGGAATGCCAGGGGAGTGGGCGGTGCCTCCAGCTC
  CTGGGGGCCAGGGTGTCTCCATACCTCATGGGCCTGAGCCTGGGCAGGGGTCTGGAGTGC
  ACATAGCCCCCAGGCAGGGAGAGGGCAGTGACAGGACAGAGCCACTCATCTGTCCCAAAG
  CTGCACCCAAGGGGTGTCAGCAACCCCAACCTACTGACCTACTTTGGACCACAGGCCCAT
  CTAGTGCAAATGAGGCCCCAGAAGGAGAAATGCTCTGCTCAACAGCCACAGTAGGCTGAC
  GTAACCTATGTAATGTATGGTCAAGGTGGGCCCTGAAGGATGAGCCACGTGGTGGGCAGG
  TGACACACCAGGTCCCCCTCCTGGGCCTTTGGCCCACCCAGCCCTCTCCTGCACGGTTAC
  CANAAGATGTCCCGGGAAGACAGACTACCCCTGAGTTAGGAGTGTGGGCCAAGTGCACAA
  GAGGGCCAGGGCCCCCGATCCTGCCCACAACACTCTTAAAN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_017882
• Insert Size: 2350 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_017882.1, NP_060352.1
• RefSeq Size: 2227 bp
• RefSeq ORF: 936 bp
• Locus ID: 54982
• UniProt ID: Q9NWW5
• Cytogenetics: 15q23
• Protein Families: Transmembrane
• Gene Summary: This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. [provided by RefSeq, Oct 2008]