E2F1 (NM_005225) Human Untagged Clone

CAT#: SC112675

E2F1 (untagged)-ORIGENE UNIQUE VARIANT 1 of Human E2F transcription factor 1 (E2F1)

USD 196


Availability*
2 Weeks

Size
    • 10 ug

Product images

Specifications

Product Data
Product Name E2F1 (NM_005225) Human Untagged Clone
Symbol E2F1
Synonyms E2F-1; RBAP1; RBBP3; RBP3
Vector pCMV6-XL6
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_005225 edited
GCGGGGGCGGAGCGGGATCGAGCCCTCGCCGAGGCCTGCCGCCATGGGCCCGCGCCGCCG
CCGCCGCCTGTCACCCGGGCCGCGCGGGCCGTGAGCGTCATGGCCTTGGCCGGGGCCCCT
GCGGGGGCGTCGGCGGACGGCTTGAGGGGTTGACCCAGGACCTCCGACAGCTGCAGGAGA
GCGAGCAGCAGCTGGACCACCTGATGAATATCTGTACTACGCAGCTGCGCCTGCTCTCCG
AGGACACTGACAGCCAGCGCCTGGCCTACGTGACGTGTCAGGACCTTCGTAGCATTGCAG
ACCCTGCAGAGCAGATGGTTATGGTGATCAAAGCCCCTCCTGAGACCCAGCTCCAAGCCG
TGGACTCTTCGGAGAACTTTCAGATCTCCCTTAAGAGCAAACAAGGCCCGATCGATGTTT
TCCTGTGCCCTGAGGAGACCGTAGGTGGGATCAGCCCTGGGAAGACCCCATCCCAGGAGG
TCACTTCTGAGGAGGAGAACAGGGCCACTGACTCTGCCACCATAGTGTCACCACCACCAT
CATCTCCCCCCTCATCCCTCACCACAGATCCCAGCCAGTCTCTACTCAGCCTGGAGCAAG
GTGGGTGATGGGTAGGTGGGTGGGGTGGGGCAGGGCCCCTCTTCTGGGGGGTGGGCAGGC
ACGACAGCCCCTGCCTTCCTCCCTGCTGGGGCATCCCCGGCCTGTGATGCTCCCCGTCTC
CCCAGAACCGCTGTTGTCCCGGATGGGCAGCCTGCGGGCTCCCGTGGACGAGGACCGCCT
GTCCCCGCTGGTGGCGGCCGACTCGCTCCTGGAGCATGTGCGGGAGGACTTCTCCGGCCT
CCTCCCTGAGGAGTTCATCAGCCTTTCCCCACCCCACGAGGCCCTCGACTACCACTTCGG
CCTCGAGGAGGGCGAGGGCATCAGAGACCTCTTCGACTGTGACTTTG
5' Read Nucleotide Sequence
>OriGene 5' read for NM_005225 unedited
GTCTATCACCCGCCCGTTGNCTCAAAGGGCGGTAGGCGTGTACGGTGGNGAGTCTATATA
AGCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCC
GCGAATTCGGCACGAGGCGGGGGCGGAGCGGGATCGAGCCCTCGCCGAGGCCTGCCGCCA
TGGGCCCGCGCCGCCGCCGCCGCCTGTCACCCGGGCCGCGCGGGCCGTGAGCGTCATGGC
CTTGGCCGGGGCCCCTGCGGGCGGCCCATGCGCGCCGGCGCTGGAGGCCCTGCTCGGGGC
CGGCGCGCTGCGGCTGCTCGACTCCTCGCAGATCGTCATCATCTCCGCCGCGCATGACGC
CAGCGCCCCGCCGGCTCCCACCGGCCCCGCGGCGCCCGCCGCCGGCCCCTGCGACCCTGA
CCTGCTGCTCTTCGCCACACCGCAAGCGCCCCGGCCCACACCCAGTGCGCCGCGGCCCGC
GCTCGGCCGCCCGCCGGTGAAGCGGAGGCTGGACCTGGAAACTGACCATCANTACCTGGC
CGAGAGCAGTGGGCCAGCTCGGGGCAGAGGCCGCCATCCAGGAAAAGGTGTGAAATCCCC
GGGGGAGAAGTCACGCTATGAGACCTCACTGAATCTGACCACCAAGCGCTTCCTGGAGCT
GCTGAGCCACTCGGCTGACGGTGTCGTCGACCTGAACTGGGCTGCCGAGGTGCTGAAGGT
GCAGAAGCGGCGCATCTATGACATCACCAACGTCCTTGATGGCATCCAGCTCATTGGCCA
GAAGTCCAAGAACACATCCAGTGGCTGGGCAGCCACACCACATTGGGCGCTCGGCGGACG
GCTTGAGGGGGTGACCCAGGACCTCCGACAGCTGCAGGAAAAGCAGCAACAGCTGGACCA
CCTGAAGAATATCTGGACTACGCAGCTGCGCCTGCGTG
3' Read Nucleotide Sequence
>OriGene 3' read for NM_005225 unedited
AGCAAATGCGTGCTCAAAACTATATTAAAACCAAGACAGNAGGCAACATAGCTGTTAGGA
AGCAAATCAAATGCAGATTGGAGGGTGGGGCAGAGCAGTGGGGAGGCAGGCGCTTCAGAC
ACTGCAGGAGGGACCACAGGGTCTGGGCTGGGGGAGGCCTTCACCACCCCTCCTGCCCAC
ATCAGTGAAGGTCCCCCACTCACCTCTCCCATCTCATATCCATCCTGGGGGGCAGCTGGG
GCCCTGAACTGGCCCCCTGGAGAGGGCCCACCCCACCATCTGACCACCCATGGCTGTCAG
TCAGTCTGTCTCCCTCCCTCACTTTCCCAATAAATAAATCACCCAGGCCTCAGTTCCTTC
AGTATGGGGCAGAAGAACAGCTCAGGGACCCCTGCCCTTGCTCAAGGGTAGAGGGAGTTG
GGGTATCAACCCCACACCCCTCCTCCCCTTTGCTGATTCCCCAGGCTCACCAAAGAGGCC
TCGATAAATAAATAACGCTCCATTAAAGCTTCAATCAGAAAAAACCTTTAAGACAGAAGT
GCTCTCACCGTCCTACACGCCCAGCCAGCCAAAGCCTCCCCACCTGGCCTGGTCAGAGCA
CCAGATTCTGGGAGCAGGCACTGCCCTGGGCCTTGTGGGACCCCCAGAGCAAAAAGGCCC
AAAGTGCATTTAGAGCCCCCCCACGCGCACACTGGGACTCATGCACACACATGTGGACAC
ACTGGGGCGTGTCTGCAGTGCACACACAAGAGTGTATGGTTACCTTTATTCCCCGGTACA
TGCCCACACACATTGCTCCACCCATTTCCCCCCCGGGACACACCTGTTGGGTTGTAGGCT
GGATGCACATTCCCACCACACAGAACTCTTTCCTTCCTGGGGTGGTCAGACCTCTATAGG
TAAGCCAC
Restriction Sites ECoRI-NOT     
Tag Tag Free
ACCN NM_005225
ORF Size 1314 bp
Insert Size 2750
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This TrueClone was found to represent an alternative form of the specific reference to which it is associated. Its Open Reading Frame (ORF) may represent a novel form or alternative splice variant. By virtue of it being a true transcript (cDNA clone not PCR product), it provides a biologically relevant copy of its mRNA template. For more details, please evaluate the sequence information provided on this website or contact our customer care specialists.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reference Data
RefSeq NM_005225.1, NP_005216
RefSeq Size 2486
RefSeq ORF 1314
Locus ID 1869
Cytogenetics 20q11.22
Domains E2F_TDP
Protein Families Transcription Factors, Druggable Genome
Protein Pathways Cell cycle, Pathways in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
Gene Summary The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations