TANK (NM_004180) Human Untagged Clone

CAT#: SC111743

TANK (untagged)-Human TRAF family member-associated NFKB activator (TANK), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TANK
• Synonyms: I-TRAF; ITRAF; TRAF2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC111743 sequence for NM_004180 edited (data generated by NextGen Sequencing)
  ATGGATAAAAACATTGGCGAGCAACTCAATAAAGCGTATGAAGCCTTCCGGCAGGCATGC
  ATGGATAGAGATTCTGCAGTAAAAGAATTACAGCAAAAGACTGAGAACTATGAGCAGAGA
  ATACGTGAACAACAGGAACAGCTGTCACTTCAACAGACTATTATTGACAAGCTAAAATCT
  CAGTTACTTCTTGTGAATTCCACTCAAGATAACAATTATGGCTGTGTTCCTCTGCTTGAA
  GACAGTGAAACAAGAAAGAATAATTTGACTCTTGATCAGCCACAAGATAAAGTGATTTCA
  GGAATAGCAAGAGAAAAACTACCAAAGGTAAGAAGACAAGAGGTTTCTTCTCCTAGAAAA
  GAAACTTCAGCAAGGAGTCTTGGCAGTCCTTTGCTCCATGAAAGGGGTAATATAGAGAAG
  ACTTTCTGGGATCTGAAAGAAGAATTTCATAAAATATGCATGCTAGCAAAAGCACAGAAA
  GACCACTTAAGCAAACTTAATATACCAGACACTGCAACTGAAACACAGTGCTCTGTGCCT
  ATACAGTGTACGGATAAAACAGATAAACAAGAAGCGCTGTTTAAGCCTCAGGCTAAAGAT
  GATATAAATAGAGGTGCACCATCCATCACATCTGTCACACCAAGAGGACTGTGCAGAGAT
  GAGGAAGACACCTCTTTTGAATCACTTTCTAAATTCAATGTCAAGTTTCCACCTATGGAC
  AATGACTCAACTTTCTTACATAGCACTCCAGAGAGACCCGGCATCCTTAGTCCTGCCACG
  TCTGAGGCAGTGTGCCAAGAGAAATTTAATATGGAGTTCAGAGACAACCCAGGGAACTTT
  GTTAAAACAGAAGAAACTTTATTTGAAATTCAGGGAATTGACCCCATAGCTTCAGCTATA
  CAAAACCTTAAAACAACTGACAAAACAAAGCCCTCAAATCTCGTAAACACTTGTATCAGG
  ACAACTCTGGATAGAGCTGCGTGTTTGCCACCTGGAGACCATAATGCATTATATGTAAAT
  AGCTTCCCACTTCTGGACCCATCTGATGCACCTTTTCCCTCACTCGATTCCCCGGGAAAA
  GCAATCCGAGGACCACAGCAGCCCATTTGGAAGCCCTTTCCTAATCAAGACAGTGACTCG
  GTGGTACTAAGTGGCACAGACTCAGAACTGCATATACCTCGAGTATGTGAATTCTGTCAA
  GCAGTTTTCCCACCATCCATTACATCCAGGGGGGATTTCCTTCGGCATCTTAATTCACAC
  TTCAATGGAGAGACTTAA
  
  Clone variation with respect to NM_004180.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004180 unedited
  CACCATTTGTATCCGACTCATATAGGCGGCCGCGCAATTCGCACGAGGGTACCTGTCATT
  TACTCCATCCTTTATAGTGATGCTACAGGACGAAGAGGAATGGATAAAAACATTGGCGAG
  CAACTCAATAAAGCGTATGAAGCCTTCCGGCAGGCATGCATGGATAGAGATTCTGCAGTA
  AAAGAATTACAGCAAAAGACTGAGAACTATGAGCAGAGAATACGTGAACAACAGGAACAG
  CTGTCACTTCAACAGACTATTATTGACAAGCTAAAATCTCAGTTACTTCTTGTGAATTCC
  ACTCAAGATAACAATTATGGCTGTGTTCCTCTGCTTGAAGACAGTGAAACAAGAAAGAAT
  AATTTGACTCTTGATCAGCCACAAGATAAAGTGATTTCAGGAATAGCAAGAGAAAAACTA
  CCAAAGGTAAGAAGACAAGAGGTTTCTTCTCCTAGAAAAGAAACTTCAGCAAGGAGTCTT
  GGCAGTCCTTTGCTCCATGAAAGGGGTAATATAGAGAAGACTTTCTGGGATCTGAAAGAA
  GAATTTCATAAAATATGCATGCTAGCAAAAGCACAGAAAGACCACTTAAGCAAACTTAAT
  ATACCAGACACTGNCACTGAAACACAGTGCTCTGTGCCCTATACAGTGTACGGATTAAAC
  AGATAAACAAGAAGCGCTGTTTAAGCCTCANGGCTAAGATGATATAAATAGAAGTGCACC
  ATCCATCACATCTGTCACACCCAGAGGACTGTGCAGAGATGAAGAAACACCTCTTTTGAA
  TCACTTTCTAAATACATGTCAAGTTTCCACTATGGACAATGACTCAACTTCTTACATAGC
  ACTCCAGAGAGACCCGGCATCCTTATTCCTGCACGTCTGGAGCAGGGTGCCAGGAAAATT
  TATTATGGAGTTCAAAAACAACCCAGGGAACTTG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004180 unedited
  CGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTACCTCTTAATATTTAATTAAT
  TTCATCATGTAGCTATACACATAGTAAAAATTAAAGCCATGTATATTATTTAAAAATCTA
  AAGTGTTTAAATAATTCTACCAGTTGTTTTATCACTGGACAAGAAATGTATTAGGTTTGA
  TATTTACAAAGATGTTTATGTTGTCTGCTATTTTCTATTATAGGTTTATTCAAAGAGAAT
  ATCACCTATAGCATAAATAATTAAATTTTTCAATAAAAACAAACTAAAAAAACCCTAGAA
  ACATTTGACATCACCAAATTCAACAGCTCTCACTAGAAATCCAAGCAATAAACTTAGATA
  TTTGAAATAAACATAAATTATGATTATATAACTCTAAGTCACATACATAATTTTGAATTA
  TAGTAATAGCACTGTAAACATGAATACAAAGGATTACAGTTTTATACAGAATTTTTTTTG
  TTTTTCTTCTTTTAGGCTTATTTCTCCTTGAAAGAACAGAATGATCTTTTAAAAAATAAG
  AGTTATATAGTAAATCCAGAAAAAAATTCAAATAGCTGTGAAACTAGATTTTCCTATAAA
  TGATCTTGAATTTAGTTTACAATCAAGTATTTATAGTATTAAAAACCCAAAATCATCACA
  TAGAACTTGATATGTCTGTTTTCAAATGTGTCTTAAGTCTCTTCATTGAAGTGTGAAATA
  AGATGCCCGAAGAAATCCCNCCTGGNATGTATGGATGGTGGGAAAACTGCTTGACAGAAT
  CACATACTCGAGTATATGCAGTTCTGAGTCTGTGCCACTTANTACACCGAGTTACTGTCT
  TGATTANGAAGGGGCTTNCAATGGNCTGCTGTGGTCCTCGNATGCTTTTCCCGGGNATCG
  AGTGAGGGAAAAGTGCATCNATGGTCCAGAANTGGAAGCTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004180
• Insert Size: 2050 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_004180.2, NP_004171.2
• RefSeq Size: 2089 bp
• RefSeq ORF: 1278 bp
• Locus ID: 10010
• UniProt ID: Q92844
• Cytogenetics: 2q24.2
• Protein Families: Druggable Genome
• Protein Pathways: RIG-I-like receptor signaling pathway
• Gene Summary: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
  Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (a).