HDAC2 (NM_001527) Human Untagged Clone
HDAC2 (untagged)-Human histone deacetylase 2 (HDAC2), transcript variant 1
|Product Name||HDAC2 (NM_001527) Human Untagged Clone|
|Synonyms||HD2; RPD3; YAF1|
>OriGene sequence for NM_001527 edited
|ORF Size||1467 bp|
|OTI Disclaimer||Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at firstname.lastname@example.org or by calling 301.340.3188 option 3 for pricing and delivery.
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
|Product Components||The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.|
|Protein Families||Stem cell - Pluripotency, Transcription Factors, Druggable Genome|
|Protein Pathways||Cell cycle, Notch signaling pathway, Huntington's disease, Pathways in cancer, Chronic myeloid leukemia|
|Gene Summary||This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].
Transcript Variant: This variant (1) encodes the functional protein.
|The use of this cDNA Clones has been cited in the following citations:|
HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma
,Kobayashi, T;Nakazono, K;Tokuda, M;Mashima, Y;Dynlacht, BD;Itoh, H;,
EMBO Rep 2016
,PubMed ID 28028031
AIRE acetylation and deacetylation: effect on protein stability and transactivation activity
,Incani, F;Serra, M;Meloni, A;Cossu, C;Saba, L;Cabras, T;Messana, I;Rosatelli, M;,
J. Biomed. Sci. Aug 2014
,PubMed ID 25158603
|cDNA Clone Resources|