WNT4 (NM_030761) Human Untagged Clone
WNT4 (untagged)-Human wingless-type MMTV integration site family, member 4 (WNT4)
|Product Name||WNT4 (NM_030761) Human Untagged Clone|
|Type||Human Untagged Clone|
|E. coli Selection||Ampicillin (100 ug/mL)|
>OriGene ORF sequence for NM_030761 edited
>OriGene 5' read for NM_030761 unedited
|Insert Size||2500 bp|
|OTI Disclaimer||Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).|
|Product Components||The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.|
|Reconstitution||1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
|RefSeq Size||1595 bp|
|RefSeq ORF||1056 bp|
|Protein Families||Druggable Genome, Secreted Protein, Transmembrane|
|Protein Pathways||Basal cell carcinoma, Hedgehog signaling pathway, Melanogenesis, Pathways in cancer, Wnt signaling pathway|
|Gene Summary||The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]|
|The use of this cDNA Clones has been cited in the following citations:|
ß-Catenin-dependent pathway activation by both promiscuous canonical WNT3a-, and specific noncanonical WNT4- and WNT5a-FZD receptor combinations with strong differences in LRP5 and LRP6 dependency
,Ring, L;Neth, P;Weber, C;Steffens, S;Faussner, A;,
Cell. Signal. Nov 2013
,PubMed ID 24269653
|cDNA Clone Resources|
|RC209205||WNT4 (Myc-DDK-tagged)-Human wingless-type MMTV integration site family, member 4 (WNT4)||
|RG209205||WNT4 (GFP-tagged) - Human wingless-type MMTV integration site family, member 4 (WNT4)||
|RC209205L3||Lenti ORF clone of Human wingless-type MMTV integration site family, member 4 (WNT4), Myc-DDK-tagged||
|RC209205L4||Lenti ORF clone of Human wingless-type MMTV integration site family, member 4 (WNT4), mGFP tagged||