ERK2(MAPK1) (NM_138957) Human Untagged Clone
MAPK1 (untagged)-Human mitogen-activated protein kinase 1 (MAPK1), transcript variant 2
|Product Name||ERK2(MAPK1) (NM_138957) Human Untagged Clone|
|Synonyms||ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2|
Fully Sequenced ORF
>OriGene ORF sequence for NM_138957 edited
5' Read Nucleotide Sequence
>OriGene 5' read for NM_138957 unedited
3' Read Nucleotide Sequence
>Forward primer walk for NM_138957 unedited
|ORF Size||1083 bp|
|OTI Disclaimer||Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at firstname.lastname@example.org or by calling 301.340.3188 option 3 for pricing and delivery.
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
|Product Components||The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.|
|Domains||pkinase, TyrKc, S_TKc|
|Protein Families||Protein Kinase, Druggable Genome|
|Protein Pathways||MAPK signaling pathway, ErbB signaling pathway, Chemokine signaling pathway, Oocyte meiosis, mTOR signaling pathway, Vascular smooth muscle contraction, Dorso-ventral axis formation, TGF-beta signaling pathway, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Gap junction, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Long-term potentiation, Neurotrophin signaling pathway, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Melanogenesis, Type II diabetes mellitus, Alzheimer's disease, Prion diseases, Pathways in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer|
|Gene Summary||This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014].
Transcript Variant: This variant (2) contains a different 3' UTR region, compared to variant 1. Both variants 1 and 2 encode the same protein.
|The use of this cDNA Clones has been cited in the following citations:|
MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7
,James Chappell, Yuhua Sun, Amar Singh, and Stephen Dalton,
Genes & Dev., Apr 2013; 27: 725 - 733.,PubMed ID 23592794
Akt plays a critical role in replication of non-segmented negative stranded RNA viruses
,Sun M, Fuentes SM, Timani K, Sun D, Murphy C, Lin Y, August A, Teng MN, He B.,
J Virol. 2008 Jan;82(1):105-14.
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