MRP1 (ABCC1) (NM_004996) Human Untagged Clone

CAT#: SC109450

ABCC1 (untagged)-Human ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MRP1
• Synonyms: ABC29; ABCC; DFNA77; GS-X; MRP; MRP1
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004996 edited
  GGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCATTTAGGTGACACTATAGAATACA
  AGCTACTTGTTCTTTTTGCAGCGGCCGCGAATTCGGCACGAGGCGGGCCCGATCACCCGC
  CGCCCGGTGCCCGCCGCCGCCCGCGCCAGCAACCGGGCCCGATCACCCGCCGCCCGGTGC
  CCGCCGCCGCCCGCGCCACCGGCATGGCGCTCCGGGGCTTCTGCAGCGCCGATGGCTCCG
  ACCCGCTCTGGGACTGGAATGTCACGTGGAATACCAGCAACCCCGACTTCACCAAGTGCT
  TTCAGAACACGGTCCTCGTGTGGGTGCCTTGTTTTTACCTCTGGGCCTGTTTCCCCTTCT
  ACTTCCTCTATCTCTCCCGACATGACCGAGGCTACATTCAGATGACACCTCTCAACAAAA
  CCAAAACTGCCTTGGGATTTTTGCTGTGGATCGTCTGCTGGGCAGACCTCTTCTACTCTT
  TCTGGGAAAGAAGTCGGGGCATATTCCTGGCCCCAGTGTTTCTGGTCAGCCCAACTCTCT
  TGGGCATCACCATGCTGCTTGCTACCTTTTTAATTCAGCTGGAGAGGAGGAAGGGAGTTC
  AGTCTTCAGGGATCATGCTCACTTTCTGGCTGGTAGCCCTAGTGTGTGCCCTAGCCATCC
  TGAGATCCAAAATTATGACAGCCTTAAAAGAGGATGCCCAGGTGGACCTGTTTCGTGACA
  TCACTTTCTACGTCTACTTTTCCCTCTTACTCATTCAGCTCGTCTTGTCCTGTTTCTCAG
  ATCGCTCACCCCTGTTCTCGGAAACCATCCACGACCCTAATCCCTGCCCAGAGTCCAGCG
  CTTCCTTCCTGTCGAGGATCACCTTCTGGTGGATCACAGGGTTGATTGTCCGGGGCTACC
  GCCAGCCCCTGGAGGGCAGTGACCTCTGGTCCTTAAACAAGGAGGACACGTCGGAACAAG
  TCGTGCCTGTTTTGGTAAAGAACTGGAAGAAGGAATGCGCCAAGACTAGGAAGCAGCCGG
  TGAAGGTCGTGTACTCCTCCAAGGATCCTGCCCAGCCGAAAGAGAGTTCCAAGGTGGATG
  CGAATGAGGAGGTGGAGGCTTTGATCGTCAAGTCCCCACAGAAGGAGTGGAACCCCTCTC
  TGTTTAAGGTGTTATACAAGACCTTTGGGCCCTACTTCCTCATGAGCTTCTTCTTCAAGG
  CCATCCACGACCTGATGATGTTTTCCGGGCCGCAGATCTTAAAGTTGCTCATCAAGTTCG
  TGAACGACACGAAGGCCCCAGACTGGCAGGGCTACTTCTACACCGTGCTGCTGTTTGTCA
  CTGCCTGCCTGCAGACCCTCGTGCTGCACCAGTACTTCCACATCTGCTTCGTCAGTGGCA
  TGAGGATCAAGACCGCTGTCATTGGGGCTGTCTATCGGAAGGCCCTGGTGATCACCAATT
  CAGCCAGAAAATCCTCCACGGTCGGGGAGATTGTCAACCTCATGTCTGTGGACGCTCAGA
  GGTTCATGGACTTGGCCACGTACATTAACATGATCTGGTCAGCCCCCCTGCAAGTCATCC
  TTGCTCTCTACCTCCTGTGGCTGAATCTGGGCCCTTCCGTCCTGGCTGGAGTGGCGGTGA
  TGGTCCTCATGGTGCCCGTCAATGCTGTGATGGCGATGAAGACCAAGACGTATCAGGTGG
  CCCACATGAAGAGCAAAGACAATCGGATCAAGCTGATGAACGAAATTCTCAATGGGATCA
  AAGTGCTAAAGCTTTATGCCTGGGAGCTGGCATTCAAGGACAAGGTGCTGGCCATCAGGC
  AGGAGGAGCTGAAGGTGCTGAAGAAGTCTGCCTACCTGTCAGCCGTGGGCACCTTCACCT
  GGGTCTGCACGCCCTTTCTGGTGGCCCTGTGCACATTTGCCGTCTACGTGACCATTGACG
  AGAACAACATCCTGGATGCCCAGACAGCCTTCGTGTCTTTGGCCTTGTTCAACATCCTCC
  GGTTTCCCCTGAACATTCTCCCCATGGTCATCAGCAGCATCGTGCAGGCGAGTGTCTCCC
  TCAAACGCCTGAGGATCTTTCTCTCCCATGAGGAGCTGGAACCTGACAGCATCGAGCGAC
  GGCCTGTCAAAGACGGCGGGGGCACGAACAGCATCACCGTGAGGAATGCCACATTCACCT
  GGGCCAGGAGCGACCCTCCCACACTGAATGGCATCACCTTCTCCATCCCCGAAGGTGCTT
  TGGTGGCCGTGGTGGGCCAGGTGGGCTGCGGAAAGTCGTCCCTGCTCTCAGCCCTCTTGG
  CTGAGATGGACAAAGTGGAGGGGCACGTGGCTATCAAGGGCTCCGTGGCCTATGTGCCAC
  AGCAGGCCTGGATTCAGAATGATTCTCTCCGAGAAAACATCCTTTTTGGATGTCAGCTGG
  AGGAACCATATTACAGGTCCGTGATACAGGCCTGTGCCCTCCTCCCAGACCTGGAAATCC
  TGCCCAGTGGGGATCGGACAGAGATTGGCGAGAAGGGCGTGAACCTGTCTGGGGGCCAGA
  AGCAGCGCGTGAGCCTGGCCCGGGCCGTGTACTCCAACGCTGACATTTACCTCTTCGATG
  ATCCCCTCTCAGCAGTGGATGCCCATGTGGGAAAACACATCTTTGAAAATGTGATTGGCC
  CCAAGGGGATGCTGAAGAACAAGACGCGGATCTTGGTCACGCACAGCATGAGCTACTTGC
  CGCAGGTGGACGTCATCATCGTCATGAGTGGCGGCAAGATCTCTGAGATGGGCTCCTACC
  AGGAGCTGCTGGCTCGAGACGGCGCCTTCGCTGAGTTCCTGCGTACCTATGCCAGCACAG
  AGCAGGAGCAGGATGCAGAGGAGAACGGGGTCACGGGCGTCAGCGGTCCAGGGAAGGAAG
  CAAAGCAAATGGAGAATGGCATGCTGGTGACGGACAGTGCAGGGAAGCAACTGCAGAGAC
  AGCTCAGCAGCTCCTCCTCCTATAGTGGGGACATCAGCAGGCACCACAACAGCACCGCAG
  AACTGCAGAAAGCTGAGGCCAAGAAGGAGGAGACCTGGAAGCTGATGGAGGCTGACAAGG
  CGCAGACAGGGCAGGTCAAGCTTTCCGTGTACTGGGACTACATGAAGGCCATCGGACTCT
  TCATCTCCTTCCTCAGCATCTTCCTTTTCATGTGTAACCATGTGTCCGCGCTGGCTTCCA
  ACTATTGGCTCAGCCTCTGGACTGATGACCCCATCGTCAACGGGACTCAGGAGCACACGA
  AAGTCCGGCTGAGCGTCTATGGAGCCCTGGGCATTTCACAAGGGATCGCCGTGTTTGGCT
  ACTCCATGGCCGTGTCCATCGGGGGGATCTTGGCTTCCCGCTGTCTGCACGTGGACCTGC
  TGCACAGCATCCTGCGGTCACCCATGAGCTTCTTTGAGCGGACCCCCAGTGGGAACCTGG
  TGAACCGCTTCTCCAAGGAGCTGGACACAGTGGACTCCATGATCCCGGAGGTCATCAAGA
  TGTTCATGGGCTCCCTGTTCAACGTCATTGGTGCCTGCATCGTTATCCTGCTGGCCACGC
  CCATCGCCGCCATCATCATCCCGCCCCTTGGCCTCATCTACTTCTTCGTCCAGAGGTTCT
  ACGTGGCTTCCTCCCGGCAGCTGAAGCGCCTCGAGTCGGTCAGCCGCTCCCCGGTCTATT
  CCCATTTCAACGAGACCTTGCTGGGGGTCAGCGTCATTCGAGCCTTCGAGGAGCAGGAGC
  GCTTCATCCACCAGAGTGACCTGAAGGTGGACGAGAACCAGAAGGCCTATTACCCCAGCA
  TCGTGGCCAACAGGTGGCTGGCCGTGCGGCTGGAGTGTGTGGGCAACTGCATCGTTCTGT
  TTGCTGCCCTGTTTGCGGTGATCTCCAGGCACAGCCTCAGTGCTGGCTTGGTGGGCCTCT
  CAGTGTCTTACTCATTGCAGGTCACCACGTACTTGAACTGGCTGGTTCGGATGTCATCTG
  AAATGGAAACCAACATCGTGGCCGTGGAGAGGCTCAAGGAGTATTCAGAGACTGAGAAGG
  AGGCGCCCTGGCAAATCCAGGAGACAGCTCCGCCCAGCAGCTGGCCCCAGGTGGGCCGAG
  TGGAATTCCGGAACTACTGCCTGCGCTACCGAGAGGACCTGGACTTCGTTCTCAGGCACA
  TCAATGTCACGATCAATGGGGGAGAAAAGGTCGGCATCGTGGGGCGGACGGGAGCTGGGA
  AGTCGTCCCTGACCCTGGGCTTATTTCGGATCAACGAGTCTGCCGAAGGAGAGATCATCA
  TCGATGGCATCAACATCGCCAAGATCGGCCTGCACGACCTCCGCTTCAAGATCACCATCA
  TCCCCCAGGACCCTGTTTTGTTTTCGGGTTCCCTCCGAATGAACCTGGACCCATTCAGCC
  AGTACTCGGATGAAGAAGTCTGGACGTCCCTGGAGCTGGCCCACCTGAAGGACTTCGTGT
  CAGCCCTTCCTGACAAGCTAGACCATGAATGTGCAGAAGGCGGGGAGAACCTCAGTGTCG
  GGCAGCGCCAGCTTGTGTGCCTAGCCCGGGCCCTGCTGAGGAAGACGAAGATCCTTGTGT
  TGGATGAGGCCACGGCAGCCGTGGACCTGGAAACGGACGACCTCATCCAGTCCACCATCC
  GGACACAGTTCGAGGACTGCACCGTCCTCACCATCGCCCACCGGCTCAACACCATCATGG
  ACTACACAAGGGTGATCGTCTTGGACAAAGGAGAAATCCAGGAGTACGGCGCCCCATCGG
  ACCTCCTGCAGCAGAGAGGTCTTTTCTACAGCATGGCCAAAGACGCCGGCTTGGTGTGAG
  CCCCAGAGCTGGCATATCTGGTCAGAACTGCAGGGCCTATATGCCAGCGCCCAGGGAGGA
  GTCAGTACCCCTGGTAAACCAAGCCTCCCACACTGAAACCAAAACATAAAAACCAAACCC
  AGACAACCAAAACATATTCAAAGCAGCAGCCACCGCCATCCGGTCCCCTGCCTGGAACTG
  GCTGTGAAGACCCAGGAGAGACAGAGATGCGAACCACCCAAAACACGCACACCCTGCCCC
  TGGTGCCCTGAGACAGACACACAGCCTCACGCCCCCAGGAATGCAAGTGGTTTCCTGGTG
  CTTCCCACGGAGGAGTTTTGGCAGCCAGACTTCTGGAGGAATTGGTTGTATAGAAGATCC
  TAGTGACCAAATTCAGCCTACTGCCTCGGATCTCTCCAGCCGAAGTCTGTGGACTGCAAG
  TCTTTGAGATGCTTCTGGCTCCCATCACCTCTAACATCCTTGTCTGGGTCTACCAGGAAC
  GCTTCATTTCCTTGGGGCTGCAGTTTTGTGGTTGAGGGGCCTGGAGAAAATCATTTTCTC
  CTCTTGGCAGTGTCCCAGGGCCCTGGATGGTCCTCTTACCAACATCTGGTCTTCCAGGCA
  CTCAAAAGCTGGGAACCAGCATCTCAGCGCCAGCTCTACCAGTTCTCGTTTTGGGCCAGA
  GGCAGCCTCTGCACTCCCACGCCTGTCCTCCTGGAAGGGACCTGGTTGGACTAACGGCTA
  ACCTGGACCTGGAACTGTAGGGCCAGGGGATTGTCTCAGGGCCGACGTTCCACCTGGGGC
  TTCCCTCCCCACCCACCCCCACTCCAGGCTTTCCCTTTTTTCTTTTGTTCAACATTGTAA
  GAACAATCAATGCTGTTATTACTGTTCCCACCATGATTGATGTGGGGTAAATATTAAGGA
  GATGGCCTCATGGGAATTTGACCTTGACTAGAAATAGAGACTGAGAGTGAGCAACCAGCT
  GGAAGGTACTATGCCAGTCCTAGCAGAAAAATGTGTTAGGGGCCTGGCCCAAAGCAGTGT
  TGGTTGCTTACAGTGTTGATTGATTTTGTTCTTTTTTCTTACCACCTCTTTTCTTTCCCT
  CTCATGGTACCTGCTCATGGTTATGAAGCTTTCAAAGTAAAGAACACGAAATACCTCCCA
  AGTATTACCAGTGGGTACCAAAAAAAAAAAAAAAAAACTCGACTCTAGATTGCGGCCGCG
  GTCATAGCTGTTTCCTGAACAGATCCCGGGTGGCATCCCTGTGACCCCTCCCCAGT
  
• Restriction Sites: Please inquire
• ACCN: NM_004996
• Insert Size: 5900 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_004996.2, NP_004987.1
• RefSeq Size: 5927 bp
• RefSeq ORF: 4596 bp
• Locus ID: 4363
• UniProt ID: P33527
• Cytogenetics: 16p13.11
• Domains: ABC_membrane, ABC_tran, AAA
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ABC transporters
• Gene Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]