PI 3 Kinase p55 gamma (PIK3R3) (NM_003629) Human Untagged Clone

CAT#: SC108470

PIK3R3 (untagged)-Human phosphoinositide-3-kinase, regulatory subunit 3 (gamma) (PIK3R3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PI 3 Kinase p55 gamma
• Synonyms: p55; p55-GAMMA; p55PIK
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003629 edited
  GAATTCGGCACGAGGGGAGCCCGAGTCCCGGCCTCTGGGGGATTCGCTCTCTGCAGACCA
  GTGGGACCCCGAAACTTGAACGCAATCTCCAGCCCCCTTTTTTGCCTTCCTTTGTCACTT
  GCCCGGGTTTCTCCCAACGTGTTCTTTTTTTTCCTCTTCATTCTCCCTCCTTCGAAGGAC
  ACAAAAGTGGCTTCCGCGGAAAGATTTGGAGGCGGTGGGAGCTTTTCTCCCCGGAGAGCG
  ACTGTGTAGAAAGGATTTTTGGGAAGCCGCTTTTTAACACCTCTGCTCTCCGTCCCCCAA
  GCCTCTGTGTAATCCTCTGAGGAGAAAAGCCCATAGCTTGAAAGTTCGGGGGCATTTTGT
  TGTGTTCTGTAGGAGAGAGGGGGAGGACCCTGTTCGGGTAGTTTGGCCGGACTGGTACTG
  GCCGTTGGAAAACCCGAAGTACATTTCCGTGTGGAACTTTTGCAGATATATATTTTTAGA
  TTTTTAAATACCAGATAAAAAATATATGCCTTCTATATATCTCCTGGCGACCTGCCCCTG
  ACAGCGCGATGTACAATACGGTGTGGAGTATGGACCGCGATGACGCAGACTGGAGGGAGC
  TCTTCCACCAAAGCCACCTAAGCCAATGACTTCAGCAGTTCCAAATGGAATGAAGGACAG
  TTCTGTTTCTCTTCAGGATGCAGAATGGTACTGGGGGGATATTTCAAGGGAGGAGGTAAA
  TGACAAATTGCGGGATATGCCAGATGGGACCTTCTTGGTCCGAGATGCCTCAACAAAAAT
  GCAGGGAGATTATACTTTGACTTTGCGGAAGGGAGGCAATAATAAGTTAATAAAGATCTA
  TCACCGGGATGGTAAATATGGCTTTTCTGATCCTCTGACATTTAATTCCGTGGTGGAGCT
  CATTAACCACTATCACCATGAATCTCTTGCTCAGTACAATCCCAAACTTGATGTGAAGCT
  GATGTACCCAGTGTCCAGATACCAACAGGATCAGTTGGTAAAAGAAGATAATATTGATGC
  AGTAGGTAAAAAACTGCAAGAATACCACTCTCAGTATCAGGAGAAGAGTAAAGAGTATGA
  TAGGCTGTATGAAGAATATACTAGAACATCCCAGGAAATACAGATGAAGAGGACTGCAAT
  AGAAGCTTTTAATGAAACAATTAAAATATTTGAAGAGCAGTGTCACACACAAGAACAACA
  TAGCAAAGAATATATTGAGCGATTTCGCAGAGAGGGGAATGAAAAGGAGATTGAACGAAT
  TATGATGAATTATGATAAATTGAAATCACGTCTGGGTGAGATTCATGATAGCAAAATGCG
  TCTAGAGCAGGATTTGAAGAAACAAGCTTTGGACAACCGAGAAATAGATAAAAAAATGAA
  TAGTATCAAACCTGACCTGATCCAGCTGCGAAAGATCCGAGATCAACACCTTGTATGGCT
  CAATCACAAAGGAGTGAGACAGAAACGCCTGAATGTCTGGCTGGGAATTAAGAATGAGGA
  TGCTGATGAGAACTATTTTATCAATGAGGAAGATGAAAACCTGCCCCATTATGATGAGAA
  AACCTGGTTTGTTGAGGATATCAATCGAGTACAAGCAGAGGACTTGCTTTATGGGAAACC
  TGATGGTGCATTCTTAATTCGTGAGAGTAGCAAGAAAGGATGCTATGCTTGCTCTGTGGT
  GGCCGATGGGGAAGTGAAGCACTGTGTGATCTACAGCACTGCTCGGGGCTATGGCTTTGC
  AGAGCCCTACAACCTGTACAGCTCTCTGAAGGAGCTAGTGCTCCATTACCAGCAGACATC
  CTTGGTTCAGCACAACGACTCCCTCAACGTCAGGCTTGCCTACCCTGTTCATGCACAGAT
  GCCCTCGCTTTGCAGATAAAGAGGAAGTGGGAAGAGAGGTGGTTCTCTGGCATTTTTTTC
  TACAGTTTTTATTAGACTACGATGAGGGCATTCTTTCTACATAGACTGCTTGTTTTGCAC
  AAGAAGTGATTTTGTGAATGTGAAGTGGAGAGGCCGAGCAGCAGCCGGCCGGGATGGGGG
  CATTAGAGGCCTGAGGTTCTCTAGGACTCAGCCATGCCGCTGCACTGACATACTAAGCTG
  GAAGCAGATGTTTTTTTTXXXXXXXXXXXXXXXXXXCTTTGGCAGTCTCTCTTCCCCCCN
  CGAAGAAGGCTGTTTAGGTTTTGTGATAGAATGGGATTTGATGAAAAAGACAACCAAAGG
  AAAATGGGGAGGNTTGGGATTTCATTTAAATAATCTAAGCCAAGATGATAAAAAAAACCT
  TCAACTGAAGGTACTTTGTTTCTTACCAACATAATTTAGGCTTCAGCATCTCACCAGCCC
  CTCCCTCTGAAGAAGTATTATGTTCAGAAGCCAACAAAACAGTTTGTTGCCAGACCAATG
  TTTGATGGGAAAACGTGGCACTCATAGTTGAATGTATACTTCTGTACCAAAACTTGAACA
  TAAAAAGACTAGAATTTGTGAGTTTTAGCAAACGCTAAAATTGATCACTGTAACTAACCC
  CTTCTGTCCTTCCTGCCTGTTTCTCTGAGATGAGGAATAGCATTCTTTTTGTGGGGATGG
  TGAGCTTTGAATCATAAAATGAAGTTGGTGCTTGTATGGTGTTTCCTTAGCCTAAAGAAT
  GATCTGTTGTTTGAAACCTTTGTAACTTGTTTGTATGAGTAAAGAAAAGGTGCAAAAAAA
  AAAAAAAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003629 unedited
  GGTCAAAAATTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGGAGCCCGAG
  TCCCGGCCTCTGGGGGATTCGCTCTCTGCAGACCAGTGGGACCCCGAAACTTGAACGCAA
  TCTCCAGCCCCCTTTTTTGCCTTCCTTTGTCACTTGCCCGGGTTTCTCCCAACGTGTTCT
  TTTTTTTCCTCTTCATTCTCCCTCCTTCGAAGGACACAAAAGTGGCTTCCGCGGAAAGAT
  TTGGAGGCGGTGGGAGCTTTTCTCCCCGGAGAGCGACTGTGTAGAAAGGATTTTTGGGAA
  GCCGCTTTTTAACACCTCTGCTCTCCGTCCCCCAAGCCTCTGTGTAATCCTCTGAGGAGA
  AAAGCCCATAGCTTGAAAGTTCGGGGGCATTTTGTTGTGTTCTGTAGGAGAGAGGGGGAG
  GACCCTGTTCGGGTAGTTTGGCCGGACTGGTACTGGCCGTTGGAAAACCCGAAGTACATT
  TCCGTGTGGAACTTTTGCAGATATATATTTTTAGATTTTTAAATACCAGATAAAAAATAT
  ATGCCTTCTATATATCTCCTGGCGACCTGCCCCTGACAGCGCGATGTACAATACGGTGTG
  GAGTATGGACCGCGATGACGCAGACTGGAGGGAGCTCTTCCACCAAAGCCACCTAAGCCA
  ATGACTTCAGCAGTTCCAAATGGAATGAAGGACAGTTCTGTTTCTCTTCAGGATGCAGAA
  TGGTACTGGGGGGATATTTCAAGGGAGGAGGGTAATGACAAATTGCGGGATATGCCAGAT
  GGGAACCTTCTTGGTCCGAGATGCCTCAACAAAATGCAGGGAGATTATACTTTGACTNTG
  CGGAAGGGAGGGCATATAAAGTAATAAAGACTATCACCGNGATGGTAATATGGCTTTTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003629 unedited
  CCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGCACCTTTTCTTTACTCA
  TACAAACAAGTTACAAAGGTTTCAAACAACAGATCATTCTTTAGGCTAAGGAAACACCAT
  ACAAGCACCAACTTCATTTTATGATTCAAAGCTCACCATCCCCACAAAAAGAATGCTATT
  CCTCATCTCAGAGAAACAGGCAGGAAGGACAGAAGGGGTTAGTTACAGTGATCAATTTTA
  GCGTTTGCTAAAACTCACAAATTCTAGTCTTTTTATGTTCAAGTTTTGGTACAGAAGTAT
  ACATTCAACTATGAGTGCCACGTTTTCCCATCAAACATTGGTCTGGCAACAAACTGTTTT
  GTTGGCTTCTGAACATAATACTTCTTCAGAGGGAGGGGCTGGTGAGATGCTGAAGCCTAA
  ATTATGTTGGTAAGAAACAAAGTACCTTCAGTTGAAGGTTTTTTTTATCATCTTGGCTTA
  GATTATTTAAATGAAATCCCAAGCCTCCCCATTTTCCTTTGGTTGTCTTTTTCATCAAAT
  CCCATTCTATCACAAAACCTAAACAGCCTTCTTCGTGGGGGGAAGAGAGACTGCCAAAGC
  AAAACACAACTCCCAGCAGAGCCATGCCCCTGCTGCACTCTCAAGAGTTAGATTTTAAAA
  AGACATGGTCTCTTCAGAGGCTTCCAAATACAACCCNCACCCGCTATAACCATCAAGCCT
  AATATTCTGTTGAGGGTGTCCTGCTAAACAAAACAAAACCCCCATGAAACAGACTTCTAA
  AAAACATCTGCTTCCAGCTTATATGTCAATGCACCGGCATGGCTGATTCCTAAAGAACCT
  CAGGCCTCTAATGCCCCCATCCCGGNCCGGTTGCTGCTCGGNCTCTCCACTTAACATTAA
  CAAAATACCTTCTTGTGGCAAAACAGCGTCTATGTAGAAAGATGCCCTCTTGTAGTCTAT
  AAAACTGTAGAAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003629
• Insert Size: 2940 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003629.2, NP_003620.2
• RefSeq Size: 5621 bp
• RefSeq ORF: 1386 bp
• Locus ID: 8503
• UniProt ID: Q92569
• Cytogenetics: 1p34.1
• Domains: SH2
• Protein Families: Druggable Genome
• Protein Pathways: Acute myeloid leukemia, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Glioma, Insulin signaling pathway, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Melanoma, mTOR signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Phosphatidylinositol signaling system, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, VEGF signaling pathway
• Gene Summary: Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]
  Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.