AIF(AIFM1) (NM_145813) Human Untagged Clone

Specifications

Product Data
Product Name	AIF(AIFM1) (NM_145813) Human Untagged Clone
Symbol	AIFM1
Synonyms	AIF; CMT2D; CMTX4; COWCK; COXPD6; NADMR; NAMSD; PDCD8
Vector	pCMV6-XL4
Sequence Data	Fully Sequenced ORF >NCBI ORF sequence for NM_145813, the custom clone sequence may differ by one or more nucleotides ATGTTCCGGTGTGGAGGCCTGGCGGCGGGTGCTTTGAAGCAGAAGCTGGTGCCCTTGGTGCGGACCGTGT GCGTCCGAAGCCCGAGGCAGAGGAACCGGCTCCCAGCTCGAGCCTTGGGCACAGAAGTGATTCAACTCTT CCCCGAGAAAGGAAATATGGGAAAGATCCTCCCCGAATACCTCAGCAACTGGACCATGGAAAAAGTCAGA CGAGAGGGGGTTAAGGTGATGCCCAATGCTATTGTGCAATCCGTTGGAGTCAGCAGTGGCAAGTTACTTA TCAAGCTGAAAGACGGCAGGAAGGTAGAAACTGACCACATAGTGGCAGCTGTGGGCCTGGAGCCCAATGT TGAGTTGGCCAAGACTGGTGGCCTGGAAATAGACTCAGATTTTGGTGGCTTCCGGGTAAATGCAGAGCTA CAAGCACGCTCTAACATCTGGGTGGCAGGAGATGCTGCATGCTTCTACGATATAAAGTTGGGAAGGAGGC GGGTAGAGCACCATGATCACGCTGTTGTGAGTGGAAGATTGGCTGGAGAAAATATGACTGGAGCTGCTAA GCCGTACTGGCATCAGTCAATGTTCTGGAGTGATTTGGGCCCCGATGTTGGCTATGAAGCTATTGGTCTT GTGGACAGTAGTTTGCCCACAGTTGGTGTTTTTGCAAAAGCAACTGCACAAGACAACCCCAAATCTGCCA CAGAGCAGTCAGGAACTGGTATCCGATCAGAGAGTGAGACAGAGTCCGAGGCCTCAGAAATTACTATTCC TCCCAGCACCCCGGCAGTTCCACAGGCTCCCGTCCAGGGGGAGGACTACGGCAAAGGTGTCATCTTCTAC CTCAGGGACAAAGTGGTCGTGGGGATTGTGCTATGGAACATCTTTAACCGAATGCCAATAGCAAGGAAGA TCATTAAGGACGGTGAGCAGCATGAAGATCTCAATGAAGTAGCCAAACTATTCAACATTCATGAAGACTG A 5' Read Nucleotide Sequence >OriGene 5' read for NM_145813 unedited NGGGGGTTCGAGATTTGTATACGATTCATATAGGGCGGCCGCGAATTCGCACGAGGTCGC CGTTCCCCTTCCCCGGCTCTAGCAGGCCGGCTTCTCTGTCCAATGCCCACCCGGAGCTGG GAGGAGGAGTCTGCGTAATGTGCGTGTGAAGAGACTGGGGGAGCTGGCCGGGGCTCACGG TGTTTGACCCGTCGGTCGTGCGTGAGAGGAAAGGGAAGGAGGAGGTCCCGAATAGCGGTC GCCGAAATGTTCCGGTGTGGAGGCCTGGCGGCGGGTGCTTTGAAGCAGAAGCTGGTGCCC TTGGTGCGGACCGTGTGCGTCCGAAGCCCGAGGCAGAGGAACCGGCTCCCAGGCAACTTG TTCCAGCGATGGCATGTTCCTCTAGAACTCCAGATGACAAGACAAATGGCTAGCTCTGGT GCATCAGGGGGCAAAATCGATAATTCTGTGTTAGTCCTTATTGTGGGCTTATCAACAGTA GGAGCTGGTGCCTATGCCTACAAGACTATGAAAGAGGATGAAAAAAGATACAATGAAAGA ATTTCAGGGTTAGGGCTGACACCAGAACAGAAACAGAAAAAGGCCGCGTTATCTGCTTCA GAAGGAGAGGAAGTTCCTCAAGACAAGGCGCCAAGTCATGTTCCTTTCCTGCTAATTGGT GGAGGCACAGCTGCTTTTGCTGCAGCCAGATCCATCCGGGCTCGGGATCCTGGGGCCAGG GTACTGATTGTATCTGAAGATCCTGAGCTGCCGTACATGCGACCTCCTCTTTCAAAAAAC TGTGGTTTTCAGATGACCCAAATGTCACAAAGACACTGCGATTCAAACAGTGGAATGGNA AAAGAGAAAGCATATATTTCCAGCCACCTTCTTCTATGTCTCTGCTCAGGACTGNCT 3' Read Nucleotide Sequence >OriGene 3' read for NM_145813 unedited GGCTCCTTTATGNACCGCGGTCCGCAATTCTANATCTCGAGTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAAAAAATCAAAATTTATTTCACTATGGGAA CCTTAAAAATTTACCTACCTAGTTGAAAATATTCACAAAGGACTTGATCATTCACACTCA TACCCAGAGAAAGTCTGCTGAATAAAAAAATGCTCCTTTACCCATTCGACCTCCTCTCAA GGGCTGCAGGGGGTTTGCCAATTCCACTGGGGGGCTTCAGTCTTCATGAATGTTGAATAG TTTGGCTACTTCATTGAGATCTTCATGCTACTCACCGGCCTTAATGATCTTCCTTGCTAT TGGCATTCGGTTAAAGATGTTCCATAACACAATCCCCACGACCACTTTGTCCCTGAGGTA AAAAATGACACCTTTGCCGTAGTCCTCCCCCTGGACGGGAGCCTGTGGAACTGCCGGGGT GCTGGGAGGAATAGTAATTTCTGAGGCCTCGGACTCTGTCTCACTCTCTGATCGGATACC AATTCCTGACTGCTCTGTGGCAAATTTGGGGTTGTCTTGTGCAGTTGCTTTTGCAAAAAC ACCAACTGTGGGCAAACTACTGTCCACAAGACCAATAGCTTCATAGCCAACATCGGGGCC CAAATCACTCCAGAACATTGACTGATGCCAGTACGGCTTAACAGCTCCAGTCATATTTTC TCCAGCCAATCNTCCACTCACACAGCGTGATCATGGTGCTCTACCCGCCTTCTTCCCAAT TTATATCGTAAAAGCCTGCAGCATCTCCTGCCACCCAAATGTTAAAGCGTGCTTGTAGCT CTGCCTTTACCCCGGAGCCACCCAAATCTGATCTATTTCCAGCA
Restriction Sites	NotI-NotI
Tag	Tag Free
ACCN	NM_145813
ORF Size	981 bp
Insert Size	2500
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reference Data
RefSeq	NM_145813.1, NP_665812
RefSeq Size	1354
RefSeq ORF	981
Locus ID	9131
Cytogenetics	Xq26.1
Protein Families	Transmembrane, Druggable Genome
Protein Pathways	Apoptosis
Gene Summary	This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015] Transcript Variant: This variant (3) lacks several in-frame exons in the 5' coding region compared to variant 1, resulting in an isoform (3) that is 287 aa shorter than isoform 1.

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