AIF(AIFM1) (NM_145813) Human Untagged Clone

CAT#: SC100268

AIFM1 (untagged)-Human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), transcript variant 3

USD 618.00


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Size
    • 10 ug

Product images

Specifications

Product Data
Product Name AIF(AIFM1) (NM_145813) Human Untagged Clone
Symbol AIFM1
Synonyms AIF; CMT2D; CMTX4; COWCK; COXPD6; NADMR; NAMSD; PDCD8
Vector pCMV6-XL4
Sequence Data
Fully Sequenced ORF
>NCBI ORF sequence for NM_145813, the custom clone sequence may differ by one or more nucleotides


ATGTTCCGGTGTGGAGGCCTGGCGGCGGGTGCTTTGAAGCAGAAGCTGGTGCCCTTGGTGCGGACCGTGT
GCGTCCGAAGCCCGAGGCAGAGGAACCGGCTCCCAGCTCGAGCCTTGGGCACAGAAGTGATTCAACTCTT
CCCCGAGAAAGGAAATATGGGAAAGATCCTCCCCGAATACCTCAGCAACTGGACCATGGAAAAAGTCAGA
CGAGAGGGGGTTAAGGTGATGCCCAATGCTATTGTGCAATCCGTTGGAGTCAGCAGTGGCAAGTTACTTA
TCAAGCTGAAAGACGGCAGGAAGGTAGAAACTGACCACATAGTGGCAGCTGTGGGCCTGGAGCCCAATGT
TGAGTTGGCCAAGACTGGTGGCCTGGAAATAGACTCAGATTTTGGTGGCTTCCGGGTAAATGCAGAGCTA
CAAGCACGCTCTAACATCTGGGTGGCAGGAGATGCTGCATGCTTCTACGATATAAAGTTGGGAAGGAGGC
GGGTAGAGCACCATGATCACGCTGTTGTGAGTGGAAGATTGGCTGGAGAAAATATGACTGGAGCTGCTAA
GCCGTACTGGCATCAGTCAATGTTCTGGAGTGATTTGGGCCCCGATGTTGGCTATGAAGCTATTGGTCTT
GTGGACAGTAGTTTGCCCACAGTTGGTGTTTTTGCAAAAGCAACTGCACAAGACAACCCCAAATCTGCCA
CAGAGCAGTCAGGAACTGGTATCCGATCAGAGAGTGAGACAGAGTCCGAGGCCTCAGAAATTACTATTCC
TCCCAGCACCCCGGCAGTTCCACAGGCTCCCGTCCAGGGGGAGGACTACGGCAAAGGTGTCATCTTCTAC
CTCAGGGACAAAGTGGTCGTGGGGATTGTGCTATGGAACATCTTTAACCGAATGCCAATAGCAAGGAAGA
TCATTAAGGACGGTGAGCAGCATGAAGATCTCAATGAAGTAGCCAAACTATTCAACATTCATGAAGACTG
A


5' Read Nucleotide Sequence
>OriGene 5' read for NM_145813 unedited
NGGGGGTTCGAGATTTGTATACGATTCATATAGGGCGGCCGCGAATTCGCACGAGGTCGC
CGTTCCCCTTCCCCGGCTCTAGCAGGCCGGCTTCTCTGTCCAATGCCCACCCGGAGCTGG
GAGGAGGAGTCTGCGTAATGTGCGTGTGAAGAGACTGGGGGAGCTGGCCGGGGCTCACGG
TGTTTGACCCGTCGGTCGTGCGTGAGAGGAAAGGGAAGGAGGAGGTCCCGAATAGCGGTC
GCCGAAATGTTCCGGTGTGGAGGCCTGGCGGCGGGTGCTTTGAAGCAGAAGCTGGTGCCC
TTGGTGCGGACCGTGTGCGTCCGAAGCCCGAGGCAGAGGAACCGGCTCCCAGGCAACTTG
TTCCAGCGATGGCATGTTCCTCTAGAACTCCAGATGACAAGACAAATGGCTAGCTCTGGT
GCATCAGGGGGCAAAATCGATAATTCTGTGTTAGTCCTTATTGTGGGCTTATCAACAGTA
GGAGCTGGTGCCTATGCCTACAAGACTATGAAAGAGGATGAAAAAAGATACAATGAAAGA
ATTTCAGGGTTAGGGCTGACACCAGAACAGAAACAGAAAAAGGCCGCGTTATCTGCTTCA
GAAGGAGAGGAAGTTCCTCAAGACAAGGCGCCAAGTCATGTTCCTTTCCTGCTAATTGGT
GGAGGCACAGCTGCTTTTGCTGCAGCCAGATCCATCCGGGCTCGGGATCCTGGGGCCAGG
GTACTGATTGTATCTGAAGATCCTGAGCTGCCGTACATGCGACCTCCTCTTTCAAAAAAC
TGTGGTTTTCAGATGACCCAAATGTCACAAAGACACTGCGATTCAAACAGTGGAATGGNA
AAAGAGAAAGCATATATTTCCAGCCACCTTCTTCTATGTCTCTGCTCAGGACTGNCT
3' Read Nucleotide Sequence
>OriGene 3' read for NM_145813 unedited
GGCTCCTTTATGNACCGCGGTCCGCAATTCTANATCTCGAGTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAAAAAATCAAAATTTATTTCACTATGGGAA
CCTTAAAAATTTACCTACCTAGTTGAAAATATTCACAAAGGACTTGATCATTCACACTCA
TACCCAGAGAAAGTCTGCTGAATAAAAAAATGCTCCTTTACCCATTCGACCTCCTCTCAA
GGGCTGCAGGGGGTTTGCCAATTCCACTGGGGGGCTTCAGTCTTCATGAATGTTGAATAG
TTTGGCTACTTCATTGAGATCTTCATGCTACTCACCGGCCTTAATGATCTTCCTTGCTAT
TGGCATTCGGTTAAAGATGTTCCATAACACAATCCCCACGACCACTTTGTCCCTGAGGTA
AAAAATGACACCTTTGCCGTAGTCCTCCCCCTGGACGGGAGCCTGTGGAACTGCCGGGGT
GCTGGGAGGAATAGTAATTTCTGAGGCCTCGGACTCTGTCTCACTCTCTGATCGGATACC
AATTCCTGACTGCTCTGTGGCAAATTTGGGGTTGTCTTGTGCAGTTGCTTTTGCAAAAAC
ACCAACTGTGGGCAAACTACTGTCCACAAGACCAATAGCTTCATAGCCAACATCGGGGCC
CAAATCACTCCAGAACATTGACTGATGCCAGTACGGCTTAACAGCTCCAGTCATATTTTC
TCCAGCCAATCNTCCACTCACACAGCGTGATCATGGTGCTCTACCCGCCTTCTTCCCAAT
TTATATCGTAAAAGCCTGCAGCATCTCCTGCCACCCAAATGTTAAAGCGTGCTTGTAGCT
CTGCCTTTACCCCGGAGCCACCCAAATCTGATCTATTTCCAGCA
Restriction Sites NotI-NotI     
Tag Tag Free
ACCN NM_145813
ORF Size 981 bp
Insert Size 2500
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reference Data
RefSeq NM_145813.1, NP_665812
RefSeq Size 1354
RefSeq ORF 981
Locus ID 9131
Cytogenetics Xq26.1
Protein Families Transmembrane, Druggable Genome
Protein Pathways Apoptosis
Gene Summary This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015]
Transcript Variant: This variant (3) lacks several in-frame exons in the 5' coding region compared to variant 1, resulting in an isoform (3) that is 287 aa shorter than isoform 1.
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