STAT3 (NM_213662) Human Untagged Clone

CAT#: SC100105

STAT3 (untagged)-Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3

USD 1,381


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Size
    • 10 ug

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Specifications

Product Data
Product Name STAT3 (NM_213662) Human Untagged Clone
Symbol STAT3
Synonyms ADMIO; APRF; HIES
Vector pCMV6-XL5
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC100105 sequence for NM_213662 edited (data generated by NextGen Sequencing)
ATGGCCCAATGGAATCAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAG
CTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGT
CAAGATTGGGCATATGCGGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTC
CTGGGAGAGATTGACCAGCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAG
CACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAG
ATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCC
ACTGCGGCCCAGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAG
CAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAG
AAAATGAAAGTGGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAG
AGTCAAGGAGACATGCAAGATCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATG
CAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGAAGCATCGTGAGTGAG
CTGGCGGGGCTTTTGTCAGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTG
GCTGACTGGAAGAGGCGGCAACAGATTGCCTGCATTGGAGGCCCGCCCAACATCTGCCTA
GATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAA
ATTAAGAAACTGGAGGAGTTGCAGCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAG
CACCGGCCGATGCTGGAGGAGAGAATCGTGGAGCTGTTTAGAAACTTAATGAAAAGTGCC
TTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAG
ACCGGCGTCCAGTTCACTACTAAAGTCAGGTTGCTGGTCAAATTCCCTGAGTTGAATTAT
CAGCTTAAAATTAAAGTGTGCATTGACAAAGACTCTGGGGACGTTGCAGCTCTCAGAGGA
TCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAACATGGAAGAATCCAAC
AACGGCAGCCTCTCTGCAGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAAT
GGGGGCCGAGCCAATTGTGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACC
TTTGAGACCGAGGTGTATCACCAAGGCCTCAAGATTGACCTAGAGACCCACTCCTTGCCA
GTTGTGGTGATCTCCAACATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTAC
AACATGCTGACCAACAATCCCAAGAATGTAAACTTTTTTACCAAGCCCCCAATTGGAACC
TGGGATCAAGTGGCCGAGGTCCTGAGCTGGCAGTTCTCCTCCACCACCAAGCGAGGACTG
AGCATCGAGCAGCTGACTACACTGGCAGAGAAACTCTTGGGACCTGGTGTGAATTATTCA
GGGTGTCAGATCACATGGGCTAAATTTTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCC
TTCTGGGTCTGGCTGGACAATATCATTGACCTTGTGAAAAAGTACATCCTGGCCCTTTGG
AACGAAGGGTACATCATGGGCTTTATCAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACT
AAGCCTCCAGGCACCTTCCTGCTAAGATTCAGTGAAAGCAGCAAAGAAGGAGGCGTCACT
TTCACTTGGGTGGAGAAGGACATCAGCGGTAAGACCCAGATCCAGTCCGTGGAACCATAC
ACAAAGCAGCAGCTGAACAACATGTCATTTGCTGAAATCATCATGGGCTATAAGATCATG
GATGCTACCAATATCCTGGTGTCTCCACTGGTCTATCTCTATCCTGACATTCCCAAGGAG
GAGGCATTCGGAAAGTATTGTCGGCCAGAGAGCCAGGAGCATCCTGAAGCTGACCCAGGT
AGCGCTGCCCCATACCTGAAGACCAAGTTTATCTGTGTGACACCATTCATTGATGCAGTT
TGGAAATAA

Clone variation with respect to NM_213662.1
5' Read Nucleotide Sequence
>OriGene 5' read for NM_213662 unedited
GTCTTGGATTTGTATCCGACTTCTATAGGCGGCCGCGCAATTCGCACGAGGTGGACAGGC
ACCCCGGCTTGGCGCTGTCTCTCCCCCTCGGCTCGGAGAGGCCCTTCGGCCTGAGGGAGC
CTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCGGCCTCTCGGCCTCTGCCGGAGAAACA
GTTGGGACCCCTGATTTTAGCAGGATGGCCCATTGGAATCAGCTACAGCAGCTTGACACA
CGGTACCTGGAGCAGCTCCATCAGCTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAG
TTTCTGGCCCCTTGGATTGAGAGTCAAGATTGGGCATATGCGGCCAGCAAAGAATCACAT
GCCACTTTGGTGTTTCATAATCTCCTGGGAGAGATTGACCAGCAGTATAGCCGCTTCCTG
CAAGAGTCGAATGTTCTCTATCAGCACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGC
AGGTATCTTGAGAAGCCAATGGAGATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAA
TCACGCCTTCTACAGACTGCAGCCACTGCGGCCCAGCAAGGGGGCCAGGCCAACCACCCC
ACAGCAGCCGTGGTGACGGAGAAGCAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGG
AAGAGAGTGCAGGATCTAGAACAGANAATGAAAGTGGTAGAGAATCTCCAGGATGACTTT
GATTTCAACTATAANACCCTCAAGAGTCAAGGAGACATGCAAGATCTGAATGGGANACAC
CAGTCAGTGACCAGGCAGAAGATGCAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAG
ATGCGGAGAAGCATCGTGAGTGAGCTGGCGGNGCTTTGTCAGCGATGGAGTACGTGCAGA
AAACTCTCACGG
3' Read Nucleotide Sequence
>OriGene 3' read for NM_213662 unedited
GCTATGAACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGAAACAGAG
TCTCAGACTGTCGCCCAGGATGGAGTGCAGTGTGCAGTGGTGCAATTTTGGCTCACTGCA
ACCTCCGCCTCTCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTA
CAGGCGCCCACCACCACACCCAGCTAATTTTTTGTACTTTTAGTAGAGACGGGGTTTCAC
CGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTTATGATCCGCCTCGGCCTCCCAAAGT
GCTGGGATTACAGGCGTGAGCCACCATGCCCGGCTGCTTAAGTTTCTTAAATACAGAAAG
GCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGGTATTATTTCTTAATTTAAAAAGAA
ACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAAT
GCCAGGAGTATGTACCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGA
TGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACACAACCACAATAACAAAAAGCTGCTG
ACAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCAC
CCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGAT
ANAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAGTGCCCACATTGCTCAAG
ATAGCACAAGTAGGAGATTAAAAAATCTGGACCCCAAGTTAGTATTTCAAAGATCTGGGT
TTGCTGGGGAGGGGCGCAAATGCAGTAGGCCCTCACCGATCTTTTGAACTCCGTCTCACT
CTTCAGGGGAGTACGCCCCCAGGCATCCTGCAAGTGGGACTAACGCCTCTGTAGGT
Restriction Sites NotI-NotI     
Tag Tag Free
ACCN NM_213662
ORF Size 2169 bp
Insert Size 3570
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reference Data
RefSeq NM_213662.1, NP_998827
RefSeq Size 4819
RefSeq ORF 2169
Locus ID 6774
Cytogenetics 17q21.2
Protein Families Transcription Factors, Druggable Genome
Protein Pathways Chemokine signaling pathway, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Pathways in cancer, Pancreatic cancer, Acute myeloid leukemia
Gene Summary The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Transcript Variant: This variant (3), also called STAT3B or STAT3beta, lacks a segment in the coding region resulting in an early termination codon, compared to variant 1. Variant 3 encodes isoform 3, which has a shorter and distinct C-terminus compared to isoform 1.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations