HLA-DRB4 (NM_021983) Human Tagged ORF Clone
CAT#: RG202743
- TrueORF®
HLA (GFP-tagged) - Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4)
Product images

Specifications
Product Data | |
Product Name | HLA-DRB4 (NM_021983) Human Tagged ORF Clone |
Symbol | HLA-DRB4 |
Synonyms | DR4; DRB4; HLA-DR4B |
Vector | pCMV6-AC-GFP |
Sequence Data |
>RG202743 representing NM_021983
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGTGTGTCTGAAGCTCCCTGGAGGCTCCTGTATGGCAGCGCTGACAGTGACATTGACGGTGCTGAGCT CCCCACTGGCTTTGGCTGGGGACACCCAACCACGTTTCTTGGAGCAGGCTAAGTGTGAGTGTCATTTCCT CAATGGGACGGAGCGAGTGTGGAACCTGATCAGATACATCTATAACCAAGAGGAGTACGCGCGCTACAAC AGTGACCTGGGGGAGTACCAGGCGGTGACGGAGCTGGGGCGGCCTGACGCTGAGTACTGGAACAGCCAGA AGGACCTCCTGGAGCGGAGGCGGGCCGAGGTGGACACCTACTGCAGATACAACTACGGGGTTGTGGAGAG CTTCACAGTGCAGCGGCGAGTCCAACCTAAGGTGACTGTGTATCCTTCAAAGACCCAGCCCCTGCAGCAC CACAACCTCCTGGTCTGCTCTGTGAATGGTTTCTATCCAGGCAGCATTGAAGTCAGGTGGTTCCGGAACG GCCAGGAAGAGAAGGCTGGGGTGGTGTCCACAGGCCTGATCCAGAATGGAGACTGGACCTTCCAGACCCT GGTGATGCTGGAAACAGTTCCTCGGAGTGGAGAGGTTTACACCTGCCAAGTGGAGCATCCAAGCATGATG AGCCCTCTCACGGTGCAATGGAGTGCACGGTCTGAATCTGCACAGAGCAAGATGCTGAGTGGAGTCGGGG GCTTTGTGCTGGGCCTGCTCTTCCTTGGGACAGGGCTGTTCATCTACTTCAGGAATCAGAAAGGACACTC TGGACTTCAGCCAACAGGACTCTTGAGC ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >RG202743 representing NM_021983
Red=Cloning site Green=Tags(s) MVCLKLPGGSCMAALTVTLTVLSSPLALAGDTQPRFLEQAKCECHFLNGTERVWNLIRYIYNQEEYARYN SDLGEYQAVTELGRPDAEYWNSQKDLLERRRAEVDTYCRYNYGVVESFTVQRRVQPKVTVYPSKTQPLQH HNLLVCSVNGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSMM SPLTVQWSARSESAQSKMLSGVGGFVLGLLFLGTGLFIYFRNQKGHSGLQPTGLLS TRTRRLE - GFP Tag - V |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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Tag | TurboGFP |
ACCN | NM_021983 |
ORF Size | 798 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers. |
Reference Data | |
RefSeq | NM_021983.4, NP_068818 |
RefSeq Size | 1193 |
RefSeq ORF | 801 |
Locus ID | 3126 |
Cytogenetics | 6p21.3 |
Domains | MHC_II_beta, ig, IGc1 |
Protein Families | Transmembrane |
Protein Pathways | Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, Type I diabetes mellitus, Asthma, Autoimmune thyroid disease, Systemic lupus erythematosus, Allograft rejection, Graft-versus-host disease, Viral myocarditis |
Gene Summary | HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]. |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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An aptamer targeting shared tumor-specific peptide antigen of MAGE-A3 in multiple cancers
,Wang, CY;Lin, BL;Chen, CH;,
Int. J. Cancer Aug 2015
,PubMed ID 26314689
[HLA-DRB4]
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Documents
Product Manuals |
FAQs |
SDS |
Resources
cDNA Clone Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC315937 | HLA (untagged)-Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4) |
USD 640.00 |
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RC202743L1 | Lenti ORF clone of Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4) , Myc-DDK-tagged |
USD 700.00 |
|
RC202743L3V | Lenti ORF particles, HLA (Myc-DDK tagged) - Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4) , 200ul, >10^7 TU/mL |
USD 910.00 |
|
RC202743L4V | Lenti ORF particles, HLA (mGFP-tagged) - Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), 200ul, >10^7 TU/mL |
USD 1,020.00 |
|
RC202743L2 | Lenti ORF clone of Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), mGFP tagged |
USD 760.00 |
|
RC202743L2V | Lenti ORF particles, HLA (mGFP-tagged) - Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), 200ul, >10^7 TU/mL |
USD 1,020.00 |
|
RC202743 | HLA (Myc-DDK-tagged)-Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4) |
USD 410.00 |
|
RC202743L4 | Lenti ORF clone of Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), mGFP tagged |
USD 760.00 |
|
RC202743L1V | Lenti ORF particles, HLA (Myc-DDK tagged) - Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4) , 200ul, >10^7 TU/mL |
USD 910.00 |
|
RC202743L3 | Lenti ORF clone of Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4) , Myc-DDK-tagged |
USD 700.00 |