Aspartate beta hydroxylase(ASPH) (NM_032467) Human Tagged ORF Clone

CAT#: RC224881

  • TrueORF®

ASPH (Myc-DDK-tagged)-Human aspartate beta-hydroxylase (ASPH), transcript variant 4

  View "NM_032467" in other vectors (6)

USD 410.00


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Size
    • 10 ug


Product images

Specifications

Product Data
Product Name Aspartate beta hydroxylase(ASPH) (NM_032467) Human Tagged ORF Clone
Symbol ASPH
Synonyms AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN; junctin
Vector pCMV6-Entry
Sequence Data
>RC224881 representing NM_032467
Red=Cloning site Blue=ORF Green=Tags(s)

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCTGAAGATAAAGAGACAAAGCATGGAGGACACAAGAATGGGAGGAAAGGCGGACTCTCAGGAACTT
CATTCTTCACGTGGTTTATGGTGATTGCATTGCTGGGCGTCTGGACATCTGTAGCTGTCGTTTGGTTTGA
TCTTGTTGACTATGAGGAAGTTCTAGGAAAACTAGGAATCTATGATGCTGATGGTGATGGAGATTTTGAT
GTGGATGATGCCAAAGTTTTATTAGAAGGACCCAGTGGGGTAGCCAAGAGAAAAACTAAGGCTAAAGTTA
AAGAACTCACTAAAGAAGAGCTCAAGAAGGAGAAAGAGAAACCTGAGTCAAGGAAGGAAAGTAAGAATGA
AGAGAGAAAAAAGGGGAAGAAAGAGGATGTCCGAAAGGATAAGAAAATTGCTGATGCAGACCTATCCAGG
AAGGAGTCTCCTAAGGGTAAAAAGGACAGAGAAAAAGAGAAAGTGGACCTAGAAAAAAGTGCTAAAACCA
AGGAAAATAGGAAAAAATCAACAAATATGAAGGATGTTTCTAGTAAAATGGCATCCCGAGACAAAGATGA
CAGAAAGGAAAGTAGAAGTTCTACCAGATATGCACACTTAACAAAGGGAAATACCCAGAAAAGAAACGGC


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAG
GTTTAA
>RC224881 representing NM_032467
Red=Cloning site Green=Tags(s)

MAEDKETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGIYDADGDGDFD
VDDAKVLLEGPSGVAKRKTKAKVKELTKEELKKEKEKPESRKESKNEERKKGKKEDVRKDKKIADADLSR
KESPKGKKDREKEKVDLEKSAKTKENRKKSTNMKDVSSKMASRDKDDRKESRSSTRYAHLTKGNTQKRNG

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites SgfI-MluI      Cloning Scheme for this gene      Plasmid Map     
Tag Myc-DDK
ACCN NM_032467
ORF Size 630 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Reference Data
RefSeq NM_032467.1, NM_032467.2, NM_032467.3, NP_115856
RefSeq Size 3242
RefSeq ORF 633
Locus ID 444
Cytogenetics 8q12.3
Domains Asp-B-Hydro_N
Protein Families Transmembrane, Druggable Genome
MW 23.8 kDa
Gene Summary This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009].

Other Versions

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Frequently bought together (3)
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