DKK2 (NM_014421) Human Tagged ORF Clone
DKK2 (Myc-DDK-tagged)-Human dickkopf homolog 2 (Xenopus laevis) (DKK2)
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|Product Name||DKK2 (NM_014421) Human Tagged ORF Clone|
>RC224432 representing NM_014421
Red=Cloning site Blue=ORF Green=Tags(s)
>RC224432 representing NM_014421
Red=Cloning site Green=Tags(s)
Sequencher program is needed, download here.
|Restriction Sites||SgfI-MluI Cloning Scheme for this gene Plasmid Map|
|ORF Size||777 bp|
|OTI Disclaimer||Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at firstname.lastname@example.org or by calling 301.340.3188 option 3 for pricing and delivery.
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
|OTI Annotation||This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.|
|Product Components||The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.|
|RefSeq||NM_014421.1, NM_014421.2, NP_055236|
|Protein Families||Stem cell relevant signaling - Wnt Signaling pathway, Secreted Protein, ES Cell Differentiation/IPS, Adult stem cells, Cancer stem cells, Druggable Genome|
|Protein Pathways||Wnt signaling pathway|
|Gene Summary||This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008].|
|The use of this cDNA Clones has been cited in the following citations:|
The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma
,von Heyking, K;Roth, L;Ertl, M;Schmidt, O;Calzada-Wack, J;Neff, F;Lawlor, ER;Burdach, S;Richter, GH;,
,PubMed ID 27363011
Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma
,Jing Zhu, Shu Zhang, Liying Gu, and Wen Di,
Carcinogenesis, Oct 2012; 10.1093/carcin/bgs278.
Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
,Desheng Lu, Michael Y. Choi, Jian Yu, Januario E. Castro, Thomas J. Kipps, and Dennis A. Carson,
PNAS, Aug 2011; 108: 13253 - 13257.
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