DNMT1 (NM_001379) Human Tagged ORF Clone

CAT#: RC217851L3

  • LentiORF®

Lenti-ORF clone of DNMT1 (Myc-DDK-tagged)-Human DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 2

  View "NM_001379" in other vectors (11)

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USD 2,210.00


Availability*
3 Weeks

Size
    • 10 ug


Product images

Specifications

Product Data
Product Name DNMT1 (NM_001379) Human Tagged ORF Clone
Symbol DNMT1
Synonyms ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI; MCMT
Vector pLenti-C-Myc-DDK-P2A-Puro
Sequence Data
The ORF insert of this clone is exactly the same as(RC217851).
Restriction Sites SgfI-MluI      Cloning Scheme for this gene     
Tag Myc-DDK
ACCN NM_001379
ORF Size 4848 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Reference Data
RefSeq NM_001379.1, NP_001370
RefSeq Size 5434
RefSeq ORF 4851
Locus ID 1786
Cytogenetics 19p13.2
Protein Families Transcription Factors, Druggable Genome
Protein Pathways Cysteine and methionine metabolism, Metabolic pathways
MW 183 kDa
Gene Summary This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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