FGFR3 (NM_000142) Human Tagged ORF Clone

CAT#: RC215533L2

Lenti ORF clone of Human fibroblast growth factor receptor 3 (FGFR3), transcript variant 1, mGFP tagged

Clone Modification / Custom Cloning Service

  • LentiORF®

USD 1,535.00


Availability*
In Stock

Size
    • 10 ug

Product images

Specifications

Product Data
Product Name FGFR3 (NM_000142) Human Tagged ORF Clone
Symbol FGFR3
Synonyms ACH; CD333; CEK2; HSFGFR3EX; JTK4
Vector pLenti-C-mGFP
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC215533).
Restriction Sites SgfI-NotI      Cloning Scheme for this gene     
Tag mGFP
ACCN NM_000142
ORF Size 2418 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Reference Data
RefSeq NM_000142.2, NP_000133
RefSeq Size 4093
RefSeq ORF 2421
Locus ID 2261
Cytogenetics 4p16.3
Domains pkinase, TyrKc, S_TKc, ig, IGc2, IG
Protein Families Protein Kinase, Transmembrane, Druggable Genome
Protein Pathways MAPK signaling pathway, Endocytosis, Regulation of actin cytoskeleton, Pathways in cancer, Bladder cancer
MW 87.71 kDa
Gene Summary This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009].
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (2)