GRK2 (NM_001619) Human Tagged ORF Clone

CAT#: RC210327L2

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  • LentiORF®

Lenti ORF clone of Human adrenergic, beta, receptor kinase 1 (ADRBK1), mGFP tagged

  View "NM_001619" in other vectors (10)

USD 860.00


Availability*
3 Weeks

Size
    • 10 ug


Product images

Specifications

Product Data
Product Name GRK2 (NM_001619) Human Tagged ORF Clone
Symbol GRK2
Synonyms ADRBK1; BARK1; BETA-ARK1
Vector pLenti-C-mGFP
E. coli Selection Chloramphenicol (34 ug/mL)
Sequence Data
The ORF insert of this clone is exactly the same as(RC210327).
Restriction Sites SgfI-RsrII      Cloning Scheme for this gene     
Tag mGFP
ACCN NM_001619
ORF Size 1449 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Reference Data
RefSeq NM_001619.2, NP_001610
RefSeq Size 3603
RefSeq ORF 2070
Locus ID 156
Cytogenetics 11q13.2
Domains RGS, pkinase, S_TK_X, TyrKc, PH, S_TKc
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Chemokine signaling pathway, Endocytosis
MW 79.4 kDa
Gene Summary This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017]

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