AMPK alpha 2(PRKAA2) (NM_006252) Human Tagged ORF Clone

CAT#: RC210226L4

Lenti ORF clone of Human protein kinase, AMP-activated, alpha 2 catalytic subunit (PRKAA2), mGFP tagged

  • LentiORF®

Need custom modification / cloning service?
Get a free quote

USD 835.00


Availability*
3 Weeks

Size
    • 10 ug

Product images

Specifications

Product Data
Product Name AMPK alpha 2(PRKAA2) (NM_006252) Human Tagged ORF Clone
Symbol PRKAA2
Synonyms AMPK; AMPK2; AMPKa2; PRKAA
Vector pLenti-C-mGFP-P2A-Puro
Sequence Data
The ORF insert of this clone is exactly the same as(RC210226).
Restriction Sites SgfI-MluI      Cloning Scheme for this gene     
Tag mGFP
ACCN NM_006252
ORF Size 1656 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Reference Data
RefSeq NM_006252.2, NP_006243
RefSeq Size 2435
RefSeq ORF 1659
Locus ID 5563
Cytogenetics 1p32.2
Protein Families Protein Kinase, Druggable Genome
Protein Pathways Regulation of autophagy, mTOR signaling pathway, Insulin signaling pathway, Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM)
MW 62.1 kDa
Gene Summary The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.