CD163 (NM_004244) Human Tagged ORF Clone

CAT#: RC208557L4

Lenti ORF clone of Human CD163 molecule (CD163), transcript variant 1, mGFP tagged

Specifications

Product Data

• Product Name: CD163 (NM_004244) Human Tagged ORF Clone
• Symbol: CD163
• Synonyms: M130; MM130; SCARI1
• Vector: pLenti-C-mGFP-P2A-Puro
• E. coli Selection: Chloramphenicol (34 ug/mL)
• Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC208557).
• Restriction Sites: SgfI-RsrII Cloning Scheme for this gene
• Tag: mGFP
• ACCN: NM_004244
• ORF Size: 3468 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.

Reference Data

• RefSeq: NM_004244.3, NP_004235
• RefSeq Size: 4190
• RefSeq ORF: 3471
• Locus ID: 9332
• Cytogenetics: 12p13.31
• Domains: SR
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• MW: 125.4 kDa
• Gene Summary: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]