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CXCR2 (NM_001557) Human Tagged Lenti ORF Clone

  • LentiORF®
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SKU
RC207794L2
Lenti ORF clone of Human chemokine (C-X-C motif) receptor 2 (CXCR2), transcript variant 1, mGFP tagged
ORF Plasmid:
mGFP DDK tGFP
Lentiviral Particles:
DDK mGFP DDK w/ Puro mGFP w/ Puro
AAV Particle:
DDK
  $757.00
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone
Target Symbol CXCR2
Synonyms CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB
Vector pLenti-C-mGFP
E. coli Selection Chloramphenicol (34 ug/mL)
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC207794).
Restriction Sites SgfI-MluI Cloning Scheme for this gene | Plasmid Map
ACCN NM_001557
ORF Size 1080 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001557.2
RefSeq Size 2880 bp
RefSeq ORF 1083 bp
Locus ID 3579
UniProt ID P25025
Cytogenetics 2q35
Domains 7tm_1
Protein Families Druggable Genome, GPCR, Transmembrane
Protein Pathways Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection
MW 40.8 kDa
Summary The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
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Documents
Resources
"NM_001557" in other vectors (6)
SKU Description Size Price
RC207794 CXCR2 (Myc-DDK-tagged)-Human chemokine (C-X-C motif) receptor 2 (CXCR2), transcript variant 1 10 ug
$457.00
RC207794L1 Lenti ORF clone of Human chemokine (C-X-C motif) receptor 2 (CXCR2), transcript variant 1, Myc-DDK-tagged 10 ug
$757.00
RC207794L3 Lenti ORF clone of Human chemokine (C-X-C motif) receptor 2 (CXCR2), transcript variant 1, Myc-DDK-tagged 10 ug
$757.00
RC207794L4 Lenti ORF clone of Human chemokine (C-X-C motif) receptor 2 (CXCR2), transcript variant 1, mGFP tagged 10 ug
$757.00
RG207794 CXCR2 (tGFP-tagged) - Human chemokine (C-X-C motif) receptor 2 (CXCR2), transcript variant 1 10 ug
$489.00 $657.00
SC321915 CXCR2 (untagged)-Human chemokine (C-X-C motif) receptor 2 (CXCR2), transcript variant 1 10 ug
$457.00

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