PARP1 (NM_001618) Human Tagged ORF Clone

CAT#: RC207085L3

Lenti ORF clone of Human poly (ADP-ribose) polymerase 1 (PARP1) , Myc-DDK-tagged

Specifications

Product Data

• Product Name: PARP1 (NM_001618) Human Tagged ORF Clone
• Symbol: PARP1
• Synonyms: ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1; PARP; PARP-1; PPOL
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC207085).
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene
• Tag: Myc-DDK
• ACCN: NM_001618
• ORF Size: 3042 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.

Reference Data

• RefSeq: NM_001618.2, NP_001609
• RefSeq Size: 3859
• RefSeq ORF: 3045
• Locus ID: 142
• Cytogenetics: 1q42.12
• Domains: PARP, BRCT, zf-PARP, PARP_reg
• Protein Families: Stem cell - Pluripotency, Transcription Factors, Druggable Genome
• Protein Pathways: Base excision repair
• MW: 112.9 kDa
• Gene Summary: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]