GJA1(GJA1) (NM_000165) Human Tagged ORF Clone
GJA1 (Myc-DDK-tagged)-Human gap junction protein, alpha 1, 43kDa (GJA1)Change vector?
|Product Name||GJA1(GJA1) (NM_000165) Human Tagged ORF Clone|
|Synonyms||AVSD3; CMDR; CX43; EKVP; GJAL; HLHS1; HSS; ODDD; PPKCA|
ORF Nucleotide Sequence
>RC205303 representing NM_000165
Red=Cloning site Blue=ORF Green=Tags(s)
>RC205303 representing NM_000165
Red=Cloning site Green=Tags(s)
Sequencher program is needed, download here.
|Restriction Sites||SgfI-MluI Cloning Scheme for this gene Plasmid Map|
|ORF Size||1146 bp|
|OTI Disclaimer||Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at email@example.com or by calling 301.340.3188 option 3 for pricing and delivery.
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
|OTI Annotation||This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.|
|Product Components||The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.|
|RefSeq||NM_000165.1, NM_000165.2, NM_000165.3, NM_000165.4, NP_000156|
|Protein Families||Ion Channels: Other, Transmembrane, Druggable Genome|
|Protein Pathways||Gap junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC)|
|Gene Summary||This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014].|
|The use of this cDNA Clones has been cited in the following citations:|
Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer
,Chen, Q;Boire, A;Jin, X;Valiente, M;Er, EE;Lopez-Soto, A;Jacob, LS;Patwa, R;Shah, H;Xu, K;Cross, JR;Massagué, J;,
Nature May 2016,PubMed ID 27225120
Homo sapiens Systemic RNA Interference-defective-1 Transmembrane Family Member 1 (SIDT1) Protein Mediates Contact-dependent Small RNA Transfer and MicroRNA-21-driven Chemoresistance
,Mohamed O. Elhassan, Jennifer Christie, and Mark S. Duxbury,
J. Biol. Chem., Feb 2012; 287: 5267 - 5277.
|cDNA Clone Resources|
"GJA1" in other Product Lines