Adenosine Receptor A2a(ADORA2A) (NM_000675) Human Tagged ORF Clone
ADORA2A (Myc-DDK-tagged)-Human adenosine A2a receptor (ADORA2A)Change vector?
|Product Name||Adenosine Receptor A2a(ADORA2A) (NM_000675) Human Tagged ORF Clone|
|Synonyms||A2aR; ADORA2; RDC8|
ORF Nucleotide Sequence
>RC204485 representing NM_000675
Red=Cloning site Blue=ORF Green=Tags(s)
>RC204485 representing NM_000675
Red=Cloning site Green=Tags(s)
Sequencher program is needed, download here.
|Restriction Sites||SgfI-MluI Cloning Scheme for this gene Plasmid Map|
|ORF Size||1236 bp|
|OTI Disclaimer||Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at email@example.com or by calling 301.340.3188 option 3 for pricing and delivery.
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
|OTI Annotation||This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.|
|Product Components||The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.|
|RefSeq||NM_000675.1, NM_000675.2, NM_000675.3, NM_000675.4, NM_000675.5, NP_000666|
|Protein Families||GPCR, Transmembrane, Druggable Genome|
|Protein Pathways||Calcium signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction|
|Gene Summary||This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013].|
|cDNA Clone Resources|
"ADORA2A" in other Product Lines