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Ptprs (NM_001252456) Mouse Untagged Clone

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SKU
MC229608
Ptprs (untagged) - Mouse protein tyrosine phosphatase, receptor type, S (Ptprs), transcript variant 4
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ORF Plasmid:
Tag Free DDK
  $1,413.00
6 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Ptprs
Synonyms AL022616; PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9; R-PTP-S; RPTPsigma
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>MC229608 representing NM_001252456
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCGCCCACCTGGAGTCCCAGCGTGGTGTCTGTGGTGGGTCCTGTGGGGCTCTTCCTCGTACTGCTGG
CCAGAGGATGCTTGGCTGAAGAACCACCCAGGTTTATCAGAGAGCCCAAGGATCAGATTGGAGTGTCGGG
AGGCGTGGCCTCCTTCGTGTGCCAGGCCACGGGTGATCCTAAGCCACGGGTGACCTGGAACAAGAAGGGC
AAGAAAGTGAACTCACAGCGCTTCGAGACCATTGACTTTGACGAGAGCTCTGGGGCGGTCCTGAGGATCC
AGCCACTTCGGACGCCTCGGGATGAGAACGTGTACGAGTGTGTGGCCCAGAACTCGGTGGGCGAAATCAC
AATTCATGCAAAGCTCACCGTCCTTCGAGAGGACCAGCTGCCTCCTGGCTTCCCCAACATTGACATGGGC
CCCCAGTTGAAGGTTGTAGAGCGCACACGCACAGCCACCATGCTCTGTGCTGCCAGCGGGAACCCGGACC
CTGAGATCACCTGGTTTAAGGACTTCCTGCCTGTGGACCCCAGTGCCAGCAACGGGCGGATCAAGCAGCT
TCGATCAGGTGCCCTGCAGATTGAGAGCAGCGAGGAGACAGACCAGGGCAAGTACGAGTGTGTGGCCACC
AACAGCGCTGGGGTGCGCTACTCATCACCTGCCAACCTCTACGTGCGAGTCCGCCGTGTGGCCCCACGCT
TCTCCATCCTGCCCATGAGCCACGAGATCATGCCCGGTGGGAATGTGAATATCACTTGTGTGGCCGTGGG
CTCACCCATGCCCTACGTGAAATGGATGCAGGGGGCCGAGGACCTGACGCCTGAGGATGACATGCCCGTG
GGTCGGAATGTTCTAGAACTCACGGATGTCAAGGACTCAGCTAACTACACTTGTGTGGCCATGTCCAGCC
TGGGTGTGATCGAGGCCGTGGCCCAGATCACTGTAAAATCTCTCCCCAAAGCCCCTGGGACTCCTGTGGT
GACGGAGAACACTGCCACCAGTATCACTGTCACATGGGACTCGGGCAACCCTGACCCCGTGTCCTACTAC
GTAATTGAGTATAAGTCCAAAAGCCAGGATGGGCCGTATCAGATCAAAGAAGACATCACCACCACGCGCT
ACAGCATCGGAGGCCTGAGCCCCAATTCTGAGTATGAGATCTGGGTGTCAGCTGTCAACTCCATTGGCCA
GGGCCCTCCCAGTGAATCGGTGGTGACCCGCACAGGTGAGCAGGCACCAGCCAGCGCTCCCAGGAATGTT
CAGGCCCGCATGCTCAGCGCCACCACCATGATCGTGCAGTGGGAGGAGCCTGTGGAGCCCAATGGCCTGA
TCCGTGGCTACCGTGTCTACTATACCATGGAGCCGGAACACCCAGTGGGCAACTGGCAGAAACACAATGT
GGACGACAGTCTCCTGACCACTGTGGGCAGCCTGCTGGAAGACGAGACCTACACCGTGCGCGTGCTCGCC
TTCACGTCGGTGGGCGACGGACCACTGTCAGACCCCATCCAGGTCAAGACCCAGCAGGGAGTTCCTGGCC
AGCCCATGAACTTGCGGGCTGAGGCCAAGTCAGAGACCAGCATTGGGCTCTCGTGGAGTGCACCACGACA
GGAGAGTGTCATTAAGTATGAACTGCTCTTCCGGGAGGGCGACCGAGGCCGAGAGGTGGGGCGAACCTTC
GACCCAACCACAGCCTTTGTGGTGGAGGACCTCAAGCCCAATACGGAGTATGCGTTCCGGCTGGCGGCGC
GCTCGCCGCAGGGCCTGGGCGCCTTCACCGCGGTCGTGCGCCAGCGCACGCTGCAGGCCATCTCCCCAAA
GAACTTCAAGGTGAAGATGATCATGAAGACTTCAGTGCTGCTGAGCTGGGAGTTCCCCGACAACTATAAC
TCACCCACACCCTACAAGATTCAGTACAATGGGCTCACCCTGGATGTGGACGGCCGCACGACCAAGAAGC
TGATCACACACCTCAAGCCACACACCTTCTATAATTTCGTGCTCACCAACCGTGGCAGCAGCCTGGGGGG
CCTGCAGCAGACGGTCACTGCCAGGACCGCCTTTAACATGCTCAGTGGCAAGCCTAGCGTCGCCCCGAAG
CCCGACAATGACGGTTTCATCGTGGTCTACCTGCCTGATGGCCAGAGTCCTGTGACCGTGCAGAACTACT
TCATTGTGATGGTCCCACTTCGGAAGTCTCGAGGTGGCCAGTTCCCTGTCCTACTAGGTAGTCCAGAGGA
CATGGATCTGGAGGAGCTCATCCAGGACATCTCCCGGCTGCAGAGGCGCAGCCTGCGCCACTCCAGACAG
CTGGAGGTGCCTCGGCCCTACATCGCCGCTCGATTCTCCATCCTGCCAGCTGTCTTCCATCCTGGGAACC
AGAAGCAATATGGTGGCTTTGACAACAGGGGCTTGGAGCCAGGCCACCGCTATGTCCTCTTTGTGCTTGC
TGTGTTGCAGAAGAATGAGCCTACATTTGCAGCCAGTCCCTTCTCAGACCCCTTCCAGCTGGACAACCCG
GACCCTCAGCCCATTGTGGACGGCGAGGAGGGCCTCATCTGGGTGATTGGGCCTGTGCTGGCCGTGGTCT
TCATCATCTGCATCGTGATTGCCATCCTGCTGTACAAGAACAAACCTGACAGCAAACGCAAGGACTCAGA
GCCCCGCACCAAATGCTTACTGAACAATGCCGACCTTGCCCCCCATCACCCCAAGGACCCTGTGGAAATG
CGACGCATCAACTTCCAGACACCAGGTATGCTCAGCCACCCACCCATCCCCATCACAGACATGGCGGAGC
ACATGGAGAGACTCAAAGCCAACGACAGCCTGAAGCTCTCCCAGGAGTACGAGTCCATTGACCCCGGGCA
GCAATTCACGTGGGAACATTCGAACCTGGAGGCCAACAAGCCCAAGAACCGCTATGCCAACGTCATCGCC
TATGACCACTCACGAGTCATCCTGCAGCCCCTAGAAGGCATCATGGGTAGTGATTACATCAATGCCAACT
ATGTGGACGGCTACCGGCGGCAGAATGCATACATTGCCACGCAGGGGCCCCTGCCTGAGACCTTTGGGGA
CTTCTGGCGGATGGTGTGGGAGCAGCGATCGGCCACTGTGGTCATGATGACGCGACTGGAGGAGAAATCA
CGGATCAAATGTGACCAATACTGGCCTAACCGAGGCACCGAGACATACGGCTTCATCCAGGTCACCCTAC
TAGATACCATGGAGCTGGCTACCTTCTGCGTCAGGACTTTTTCTCTACACAAGAATGGCTCTAGCGAGAA
GCGTGAGGTGCGACATTTCCAGTTCACGGCATGGCCCGACCACGGGGTACCTGAGTACCCCACGCCCTTC
CTGGCATTCCTGCGAAGAGTCAAGACCTGCAACCCGCCTGATGCTGGCCCCATTGTGGTCCACTGCAGCG
CGGGTGTGGGGCGCACTGGCTGCTTCATCGTAATTGACGCCATGCTAGAGCGCATCAAGACAGAGAAGAC
CGTGGATGTGTATGGACATGTGACACTCATGCGGTCGCAGCGCAACTACATGGTGCAGACAGAGGATCAG
TATGGCTTCATCCACGAGGCGCTGCTGGAGGCTGTGGGCTGCGGCAATACCGAGGTCCCTGCTCGCAGCC
TCTACACCTACATCCAGAAGCTGGCCCAGGTGGAGCCTGGCGAGCACGTCACGGGCATGGAGCTTGAGTT
CAAGAGGCTCGCCAGTTCCAAGGCACACACTTCGCGCTTCATCACCGCCAGCCTGCCTTGCAACAAGTTT
AAGAACCGACTGGTGAACATCCTGCCGTACGAGAGCTCGCGTGTCTGCCTGCAGCCCATCCGCGGTGTGG
AGGGCTCTGACTACATCAATGCCAGCTTTATCGACGGCTATAGACAGCAGAAAGCCTACATTGCAACACA
GGGGCCACTGGCAGAGACCACAGAGGACTTCTGGCGAGCTCTGTGGGAGAACAACTCTACTATTGTCGTA
ATGCTCACCAAGCTCCGAGAAATGGGCCGGGAAAAGTGCCACCAGTACTGGCCAGCCGAGCGCTCTGCCC
GCTACCAGTACTTTGTGGTTGACCCGATGGCAGAGTATAACATGCCACAGTACATTCTGCGTGAGTTTAA
GGTCACAGATGCCCGGGATGGCCAGTCCCGGACCGTCCGACAGTTCCAGTTCACGGACTGGCCAGAGCAG
GGTGCACCCAAGTCAGGGGAAGGCTTCATTGACTTCATCGGCCAAGTGCATAAGACCAAGGAGCAGTTTG
GCCAGGACGGACCCATCTCAGTGCACTGCAGCGCCGGAGTGGGCAGGACCGGAGTGTTCATCACCCTGAG
CATCGTGCTTGAGCGGATGCGCTACGAGGGCGTGGTGGACATTTTCCAGACAGTGAAGGTGCTTCGGACC
CAGAGGCCTGCCATGGTGCAGACAGAGGACGAGTACCAGTTCTGCTTCCAGGCGGCTTTGGAATACCTGG
GCAGTTTTGATCATTATGCAACATAA

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI |
ACCN NM_001252456
Insert Size 4506 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation Clone contains native stop codon, and expresses the complete ORF without any c-terminal tag.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001252456.1, NP_001239385.1
RefSeq Size 5618 bp
RefSeq ORF 4506 bp
Locus ID 19280
UniProt ID B0V2N1
Cytogenetics 17 29.32 cM
Summary Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:19833921, PubMed:21454754, PubMed:22406547). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (PubMed:21454754). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:15797710, PubMed:19833921, PubMed:19780196, PubMed:21454754, PubMed:22519304, PubMed:22406547). Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754). Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (PubMed:10080191). Functions as tyrosine phosphatase (PubMed:7529177). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (PubMed:15797710). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).UniProtKB/Swiss-Prot Function
Transcript Variant: This variant (4) differs in the 5' UTR and lacks four consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
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Documents
Resources
"NM_001252456" in other vectors (1)
SKU Description Size Price
MR231819 Ptprs (myc-DDK-tagged) - Mouse protein tyrosine phosphatase, receptor type, S (Ptprs), transcript variant 4 10 ug
$589.00 $1,284.00

file-alt Citations

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