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Sh2b2 (NM_001302938) Mouse Untagged Clone

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SKU
MC228501
Sh2b2 (untagged) - Mouse SH2B adaptor protein 2 (Sh2b2), transcript variant 2
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ORF Plasmid:
Tag Free DDK
AAV Particle:
DDK
  $637.00
3 Weeks*
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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Sh2b2
Synonyms Aps
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>MC228501 representing NM_001302938
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGAATGGTGCCACCCCCAGCTCGGCCGCCGCCCCCGCCCCAGTCCCCGACTGGCGGCAATTCTGCGAGC
TGCACGCGCAGGTGGCTGCTGTGGACTTCGCACACAAGTTCTGCCGCTTCCTTCGGGACAACCCGACCTA
CGACACGCCTGACGCTGGGACCTCATTCTCCCGCCACTTTGCAGCCAACTTCTTGGCTGTCTTCAGTGAG
GAGGTGCGCCGCGTGCTGGGGTCAGCAGCCGACACTATGGAACCCGAGCCTGCGGTGACCTCGGTGACAT
CTGCGCTCAAGACTGCAACCTATGGCCACTCCCGCAGCTCCGAGGATGTGTCTGCCCACGCGGCTACCAA
GGCGCGTGTCCGAAAGGGATTCTCGCTGCGTAACATGAGCCTGTGTGTGGTGGATGGAGTGCGCGACCTG
TGGCACCGGCGCTCGTCCCCAGAGCCCGATGGTGGGGCCACCCCCAAGGCCGCCGAGCCTGCGTCGGAGC
CTCGTGACAAATGGACGCGACGCCTGCGGCTAGCACGAACCCTGGCAGCCAAAGTGGAGTTAGTGGACAT
CCAGCGTGAGGGCGCCCTGCGCTTCATGGTGGCAGACGACGCGGCCTCAGGGCCTGGAGGCACTGCGCAG
TGGCAGAAGTGTCGCCTGCTCCTGCGGAGGGCTGTGGCTGGGGAACGTTTCCGCCTGGAGTTCTTCGTGC
CACCCAAGGCTTCCAGACCCAAGGTCAGCATCCCCCTGTCGGCCATCATTGAGGTCCGAACCACTATGCC
CCTGGAAATGCCTGAAAAGGACAACACATTTGTGCTCAAGGTGGAGAACGGAGCAGAATACATCCTGGAA
ACGATAGACTCACTGCAGAAGCACTCGTGGGTGGCTGACATCCAGGGCTGTGTGGATCCTGGGGACAGTG
AGGAAGACACAGGACTGTCTTGTGCACGGGGAGGCTGCCTGGCCAGCCGCGTGGCCTCCTGCAGCTGTGA
GCTCCTGACAGATGCAGACATGCCCCGGCCCCCCGAGACGACGACAGCGGTGGGTGCTGTGGTCACAGCT
CCACATGGCCGAGCTCGTGACACCGTGGGAGAGTCCCTGGCCCACGTTCCCCTGGAGACTTTCCTGCAAA
CCCTGGAGTCTTCAGGTGGTGTCAGTGAGAACAATAACCCAGGGGACGAAGGAGCTGAGCTGGACACCGA
TGCTGAGGCTGAGCTGGAACTTTCCGACTACCCCTGGTTCCATGGGACATTGTCCCGGGTGAAGGCGGCC
CAGCTTGTGCTGGCCGGTGGCCCTCGGAGCCATGGCCTCTTTGTGATCCGCCAAAGTGAGACTAGGCCTG
GGGAGTGTGTGCTGACCTTCAACTTCCAGGGCAAGGCCAAGCACCTCCGCCTTTCTCTGAACGGTCACGG
CCAGTGTCATGTCCAGCACCTGTGGTTCCAGTCCGTGTTTGATATGCTCCGTCACTTCCACACCCACCCC
ATCCCCCTGGAGTCAGGAGGATCGGCTGATATCACCCTAAGAAGCTATGTGCGTGCCCAGGGCCCGCCTC
CTGATCCAGGACCAGCGCCCAACACTGCGGCCCCAGTTCCAGCCTGCTGGACGGAGCCGGCTGGCCAGCA
CTACTTCTCCAGCCTGGCCACGGCCACTTGCCCGCCCGCTTCACCGTCCAATGGCGCTGGAGCTTCGTCT
TCATCCGGCTCATCGTCCTCTGCCACATCCCTGCCCCCACGCCCAGCCGAGGGGCCGCTCAGTGCGCACA
GCCGCAGCAACAGCACAGAGCACCTGCTGGATGCTGCATCTGGAGCCACTGAGGAGCCCACAGAGGCCAC
GCTGGGCCGTGCTCGTGCTGTGGAGAATCAGTACTCCTTTTACTAG

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI |
ACCN NM_001302938
Insert Size 1866 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation Clone contains native stop codon, and expresses the complete ORF without any c-terminal tag.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001302938.1, NP_001289867.1
RefSeq Size 2900 bp
RefSeq ORF 1866 bp
Locus ID 23921
UniProt ID Q9JID9
Cytogenetics 5 G2
Summary Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity).UniProtKB/Swiss-Prot Function
Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
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Documents
Resources
"NM_001302938" in other vectors (1)
SKU Description Size Price
MR230712 Sh2b2 (myc-DDK-tagged) - Mouse SH2B adaptor protein 2 (Sh2b2), transcript variant 2 10 ug
$289.00 $578.00

file-alt Citations

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