Ltbp4 (NM_001113549) Mouse Untagged Clone

CAT#: MC224737

Ltbp4 (untagged) - Mouse latent transforming growth factor beta binding protein 4 (Ltbp4), transcript variant 2, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Ltbp4
• Synonyms: 2310046A13Rik
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC224737 representing NM_001113549
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCGGGCGGCGCGCAGCTGCTCTGGGTGTCGCTATTGGTGCTGCTGGCGCAGCTGGGGCCGCAGCCCG
  TACTGGGCCGACCCCGAGAGCGTCTTCGCGTGCGCTTCACCCCCGCTGTGTGCGGCCTGCGTTGCATCCA
  CGGGCCCACTGGCTCCCGCTGTACCCCGACCTGCGCGCCCCGCAACGCCACCAGCGTGGACAGCGGCGCG
  CCCGGCGGGGCGGCCCCGGGGGGACCCGGCTTCCGCGCCTTCCTATGTCCCTTGATCTGTCACAACGGTG
  GTGTGTGTGTGAAGCCTGATCGCTGCCTTTGCCCCCCGGACTTCGCTGGCAAATTCTGCCAATTGCATTC
  TTCGGGGGCCCGGCCCCCGGCCCCAGCCATGCCGGGCCTTACCCGCTCCGTTTATACAATGCCACTAGCC
  AACCACCGCGATGATGAACACGGAGTAGCATCGATGGTGAGCGTGCACGTGGAGCACCCTCAGGAGGCAT
  CAGTGGTGGTGCACCAAGTGGAACGTGTGTCGGGCCCCTGGGAGGAGGCGAACCCTGAAGCCCTAGCCAG
  GGCTGAAGCGGCGGCACGGGCCGAGGCGGCGGCGCCCTACACAGTGCTGGCACAGAGCGCGCCACGCGAG
  GACGGCTACTCAGACGCCTCCGGCTTCGGTTACTGTTTTAGAGAACTGCGCGGAAGCGAATGTGCATCGC
  CGCTGCCAGGGCTCCGGACGCAGGAAGTCTGCTGCCGAGGAGAGGGCTTGGCCTGGGGTGTTCATGATTG
  TCACCCGTGCGCGGAACACCTGAGGAACTCCAACCAAGTGAGTGGCCCAAATGGACCTTGTCCACCCGGC
  TTCGAGAGAGTTAATGGGTCCTGTGTAGATGTGGATGAGTGCGCCACCGGTGGGCGTTGCCAACACGGGG
  AGTGTGCCAACACTCGTGGCGGCTACACGTGTGTATGTCCGGACGGTTTCCTCCTGGACTCTTCCCGCAG
  CAGCTGCATCTCCCAACACGTGATCTCCGAGGCAAAGGGGCCCTGCTACCGAGTGCTGCATGATGGCGGA
  TGCTCGCTGCCCATTCTTCGAAATATCACCAAACAGATCTGCTGCTGTAGCCGTGTGGGCAAGGCGTGGG
  GCCGAGGCTGCCAGCTCTGTCCACCTTATGGTTCAGAGGGTTTTCGGGAGATCTGTCCAGCTGGCCCTGG
  CTACCACTATTCAGCTTCTGACCTCCGATACAACACCAGACCCCTAAACCAGGATCCACCTCGAGTGACC
  TTCAATCAGCCACGTGTTCCACCAGCCACCCCTCGGCCACCTACAGGCTTTCTGCCTACTCGTCGACCTG
  AGCCCCGCCCTGACCCTGGGCCACAGCCTGAACCCCGGCCTCGGCCTGAACCCCGGCCTCGGCCTGAATC
  CCGACCTCGGCCTGAACCCCGGCCTCGGCCTGAACCCCGGCCTCAGCCTGAATCCCAGCCTAGGCCTGAA
  TCCCGGCCTCGGCCTGAATCCCAGCCTTGGCCTGAATTTCCCCTGCCCAGCATCCCTGCTTGGACCGGTC
  CAGAGATTCCTGAATCAGGTCCCTCTTCCAGCATGTGTCAGCGAAATCCCCAGGTTTGTGGTCCTGGACG
  CTGCGTTCCTAGGCCAAGCGGCTACACTTGTGCGTGCGACCCAGGTTTCCGGCTCGGCCCCCAGGGCACT
  CGCTGCATTGACATAGATGAATGTCGCCGCGTCCCTACACCCTGTGCTCCTGGGCGTTGCGAGAATACAC
  CAGGCAGCTTTCGCTGCGTGTGCGGCACGGGCTTCCAAGCAGGCCCGCGGGCTACAGAGTGCCTGGATGT
  GGACGAGTGCCGCCGCGTGCCGCCGCCGTGTGACCGCGGGCGCTGCGAGAACACGCCAGGCAGTTTCCTA
  TGTGTGTGTCCCGCCGGGTACCAGGCAGCACCGCACGGAGCCAGCTGCCAGGATGTGGATGAATGCACCC
  AGAGCCCAGGCCTCTGTGGTCGCGGGGTCTGCGAAAACCTGCCCGGCTCTTTCCGCTGTGTTTGCCCGGC
  TGGCTTCCGGGGCTCGGCGTGTGAAGAAGATGTGGATGAATGTGCCCAGCAGCCTCCGCCTTGCGGGCCA
  GGCCGCTGCGACAACACCGCGGGTTCGTTCCACTGTGCCTGCCCAGCTGGCTTCCGATCCCGAGGACCAG
  GAGCCCCCTGCCAAGATGTGGATGAATGTTCCCGGAGCCCCTCGCCTTGTGCCTATGGCCGCTGTGAGAA
  CACGGAAGGCAGCTTCAAGTGTGTCTGCCCAACAGGCTTCCAACCCAACGCTGCGGGCTCCGAGTGCGAG
  GATGTGGATGAGTGTGAGAACCGCTTGGCGTGTCCAGGGCAGGAGTGTGTGAACTCACCGGGCTCCTTCC
  AGTGCCGGGCCTGCCCTGTTGGGCACCACCTGCACCGTGGCAGATGTACTGATGTGGATGAATGCAGTTC
  GGGCACCCCTTGTGGTCTCCATGGCCAGTGCACAAATACTAAAGGCTCCTTCCACTGCAGCTGCTCGACA
  GGTTACCGGGCGCCATCTGGTCAACCTGGGCCTTGTGCAGACATAAATGAGTGTCTGGAAGGCGACTTCT
  GCTTCCCCCACGGAGAGTGCCTCAACACTGATGGCTCCTTTACCTGTACCTGTGCCCCTGGCTACCGGCC
  TGGACCTCGTGGAGCATCTTGTCTGGACGTGGACGAGTGCAGCGAAGAGGATCTTTGCCAGAGCGGCATC
  TGTACCAACACTGACGGCTCCTTCGAGTGCATCTGTCCTCCTGGACACCGCGCTGGCCCTGACCTTGCCT
  CCTGCCTTGACATTGACGAGTGTCGTGAACGGGGACCTGCCCTGTGCGGGTCTCAGCGCTGTGAAAATTC
  TCCTGGTTCCTACCGCTGTGTGCGGGACTGCGATCCAGGTTACCACCCCGGCCCTGAGGGCACCTGTGAT
  GACATTGATGAGTGCCGAGAATACGGCTCTGCGATTTGTGGTGCCCAGCGCTGTGAGAACACCCCGGGCT
  CCTACCGCTGCACACCAGCCTGCGACCCTGGCTATCAGCCTACACCAGGGGGCGGGTGCCAAGATGTGGA
  TGAATGCCGGAACCGGTCTTTCTGCGGCGCCCATGCTATGTGCCAGAATCTGCCTGGGTCCTTTCAGTGC
  GTCTGTGACCAAGGCTACGAAGGGGCACGGGACGGACGTCACTGCGTGGATGTGAATGAGTGTGAGACAC
  TACAGGGCGTGTGTGGCTCCGCGCTGTGTGAAAATGTTGAAGGCTCCTTCCTGTGTGTCTGCCCCAATAG
  CCCTGAGGAATTTGATCCCATGACTGGACGCTGTGTTCCCCCACGGGCTCCTGCAGGCACGTTCCCTGGC
  TCCCAGCCCCAAGCACCTGCCAGCCCCAGTCTTCCAGCCAGGCCACCAGCCCCTCCCCCACCTCGAAGAC
  CCAGCCCTCCCAGGCAGGGTCCCGTGAGCAGTGGACGTCGCGAGTGCTACTTTGATACAGCCGCTCCAGA
  TGCGTGTGACAATATCTTGGCCCGAAACGTGACGTGGCAGGAGTGCTGCTGTACTGTGGGAGAAGGCTGG
  GGCAGCGGCTGCCGCATCCAACAGTGCCCGGGCACCGAGACAGCTGAATACCAGTCATTGTGTCCTCACG
  GCCGGGGCTACCTGGTGCCCAGTGGAGACCTGAGTGCCCGGAGAGATGTGGACGAATGCCAACTCTTCCA
  GGACCAGGTGTGCAAGAGCGGAGTGTGTGTGAACACGGCCCCAGGCTACTCTTGCTATTGCAGCAACGGG
  TTCTACTATCACGCACACAGGCTGGAGTGCGTTGATAATGACGAATGTGCGGACGAGGAGCCTGCTTGTG
  AAGGTGGCCGCTGCGTCAACACGGTGGGCTCTTACCACTGTACCTGCGAGCCCCCACTGGTGCTGGACGG
  CTCCCGGCGACGCTGCGTCTCCAACGAGAGCCAGAGCCTGGATGACAATCTAGGAGTGTGCTGGCAGGAA
  GTGGGACCTGATCTCGTCTGCAGTCGCCCACGACTAGACCGGCAGGCCACCTACACCGAGTGCTGCTGTC
  TCTATGGTGAAGCCTGGGGTATGGACTGCGCTCTCTGTCCTGCCCAGGACTCAGATGACTTTGAGGCCCT
  TTGCAATGTGCTGCGTCCACCTGCCTATGGCCCGCCGCGCCCTGGTGGCTTTGGAATTCCCTATGAATAT
  GGCCCAGATATAGGCCCACCTTATCAGAGTCTCCCCTATGGGCCAGATCTGTATCCACCGCCAGTGCTAC
  CCTACGACCCCTACCCACCCCCACCTGGACCCTTTGCTCGCCGGGAGGCCCCTTATGGCGCCCCACCCTT
  CGACATGCCGGACTTTGAGGATGATGGTGGCCCCTATGGCGAGTCTGAGACTCCTGACCCACCTAGCCGA
  GGCACTGGTTGGCCTTATCGGTCCAGAGACACCCGTGGCTCCTTCCCAGAGCCTGAGGAATCCTCTGAGC
  GTGGAAGCTATACAGGAGCCTTGTCTGAGCCCTATGAGGGCCTAGAGGCCGAAGAGTGTGGTATCCTGGA
  TGGCTGCCCTCACGGCCGCTGTGTGCGCGTTCCAGAAGGCTTCACCTGCGATTGTTTCGATGGCTACCGC
  CTGGACATCACCCGCATGTCCTGTGTCGACGTCAACGAGTGTGATGAGGCAGAGGCAACCTCCCCACTCT
  GCGTCAATGCGCGCTGTGTCAACACTGACGGCTCCTTCCGCTGTATCTGTCGTCCAGGATTTGCTCCCAC
  GCATCAGCCACATCACTGTGCGCCTGCTCGACCCCGGGCCTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_001113549
• Insert Size: 4803 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001113549.1, NP_001107021.1
• RefSeq Size: 5123 bp
• RefSeq ORF: 4803 bp
• Locus ID: 108075
• UniProt ID: Q8K4G1
• Cytogenetics: 7 A3
• Gene Summary: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.