Pla2r1 (NM_008867) Mouse Untagged Clone
$1,273.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
|---|---|
| Target Symbol | Pla2r1 |
| Synonyms | Pla2-r; Pla2g1br; Pla2r |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites | SgfI-RsrII | |
| ACCN | NM_008867 |
| Insert Size | 4464 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | BC141355, AAI41356 |
| RefSeq Size | 4653 bp |
| RefSeq ORF | 4464 bp |
| Locus ID | 18779 |
| UniProt ID | Q62028 |
| Cytogenetics | 2 C1.1 |
| Summary | Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipases sPLA2-IB/PLA2G1B, sPLA2-X/PLA2G10 and, with lower affinity, sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10.UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_008867" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MG220670 | Pla2r1 (tGFP-tagged) - Mouse phospholipase A2 receptor 1 (Pla2r1), (10ug) | 10 ug |
$1,472.00
|
|
| MR220670 | Pla2r1 (Myc-DDK-tagged) - Mouse phospholipase A2 receptor 1 (Pla2r1) | 10 ug |
$589.00
$1,272.00
|
|
| MR220670L3 | Lenti ORF clone of Pla2r1 (Myc-DDK-tagged) - Mouse phospholipase A2 receptor 1 (Pla2r1) | 10 ug |
$1,572.00
|
|
| MR220670L4 | Lenti ORF clone of Pla2r1 (mGFP-tagged) - Mouse phospholipase A2 receptor 1 (Pla2r1) | 10 ug |
$1,572.00
|
|
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