Naip5 (NM_010870) Mouse Untagged Clone
$1,321.00
7 Weeks*
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
|---|---|
| Target Symbol | Naip5 |
| Synonyms | Birc1e; Lgn1; Naip-rs3 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | SgfI-MluI | |
| ACCN | NM_010870 |
| Insert Size | 4212 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_010870.2, NP_035000.2 |
| RefSeq Size | 5368 bp |
| RefSeq ORF | 4212 bp |
| Locus ID | 17951 |
| UniProt ID | Q9R016 |
| Cytogenetics | 13 53.05 cM |
| Summary | Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria such as Legionella or Salmonella (PubMed:12526741, PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). May contribute to prevent motor-neuron apoptosis induced by a variety of signals (By similarity).UniProtKB/Swiss-Prot Function |
Reviews
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Resources
"NM_010870" in other vectors (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MR211969 | Naip5 (Myc-DDK-tagged) - Mouse NLR family, apoptosis inhibitory protein 5 (Naip5) | 10 ug |
$589.00
$1,200.00
|
|
| MR211969L3 | Lenti ORF clone of Naip5 (Myc-DDK-tagged) - Mouse NLR family, apoptosis inhibitory protein 5 (Naip5) | 10 ug |
$1,500.00
|
|
| MR211969L4 | Lenti ORF clone of Naip5 (mGFP-tagged) - Mouse NLR family, apoptosis inhibitory protein 5 (Naip5) | 10 ug |
$1,500.00
|
|
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.