Wdr11 (NM_172255) Mouse Untagged Clone

CAT#: MC223992

Wdr11 (untagged) - Mouse WD repeat domain 11 (Wdr11), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Wdr11
• Synonyms: 2900055P10Rik; AW489876; Brwd2; mKIAA1351
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC223992 representing NM_172255
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGTTACCCTACACCGTAAACTTCAAGGTGTCAGCGCGCACCCTCACCGGGGCTCTCAACGCGCACAACA
  AGGCGGCGGTGGACTGGGGCTGGCAAGGTTTAATTGCATATGGATGCCATTCACTGGTGGTAGTGATCGA
  TTCCAATACTGCCCAAACTCTACAAGTTCTAGAAAAACATAAAGCTGATATTGTTAAGGTCAGGTGGGCC
  AGGGAGAACTATCACCATAACATCGGCTCTCCATACTGCCTGCGCTTGGCTTCTGCGGATGTCACTGGGA
  AGATCATTGTCTGGGATGTAGCAGCCGGAGTAGCCCAGTGTGAGATCCAAGAGCACGTGAAGCCCATCCA
  AGATGTGCAGTGGCTGTGGAATCAGGACGCTTCCCGAGACTTGCTGCTCGCTATCCACCCGCCTAATTAC
  ATCGTGCTGTGGAATGCAGACACAGGCACCAAGCTGTGGAAGAAGAGCTACGCAGATAACATCCTTTCTT
  TTTCTTTTGACCCTTTTGATCCTTCACATTTAACTTTACTCACCAGCGAGGGCATCGTTTTCATCTCAGA
  CTTCTCTCCATCCAAGCCTCCCTCCGGCCCTGGGAAGAAAGTGTACATCTCCAGCCCACACTCCAGCCCA
  GCTCATAACAAGCTGGCCGCAGCCACGGGAGCCAAGAAGGCTCTTAATAAAGTAAAGATTTTAATCACTC
  AGGAGAAACCGAGTGCTGATTTTGTAGCTCTCAATGACTGCCTCCAGTTAGCCTATCTGCCTTCAAAAAG
  GAATCACATGCTGTTGCTCTACCCTCGGGAGATTTTAATCCTTGACCTGGAAGTGAATCAAACAGTTGGT
  GTGATTGCAATCGAGAGAACAGGCGTTCCCTTTCTGCAGGTAATACCATGCTCTCAGCGAGATGGCTTGT
  TTTGCCTACATGAAAATGGCTGCATAACCTTACGTGTCCGGAGGTCTTATAACAGCATCTGTACTACATC
  AAATGATGAACCAGATCTAGATCCTGTCCAGGAGCTTACCTATGACTTGAGAAGCCAGTGTGATGCAATC
  AGGGTGACGAAAACTGTCCGTCCCTTCAGTATGGTGTGCTGTCCTGTTAATGAGAATGCAGCTGCCCTCA
  TAGTAAGCGACGGCAGAGTCATGATATGGGAACTCAAGTCTGCTGTGTGCAGTCGAAATGCACGGAACAG
  TTCCGGTGTGTCTCCTTTATACTCGCCAGTGTCCTTCTGTGGGATTCCTGGAGGAGTGCTACAGAATAAA
  CTCCCAGACCTTTCCCTAGATAATATGATCGGGCAGAGTGCAATTGCTGGGGAAGAACACCCCAAAGGCT
  CCATTCTGCAGGAAGTGCACCTCAAGTTCCTGCTGACGGGACTGCTCTCAGGACTCCCTTCCCCTCAGTT
  TGCCATCCGAATGTGCCCACCACTGACCACAAAAAACATTAAGATGTACCAGCCACTCCTTGCTGTTGGT
  ACGAGTAACGGTTCTGTCCTGGTGTACCACCTCACCAGTGGCCTGCTGCACAAGGAGCTCAGTGTCCACT
  CGTGTGAAGTCAAGGGTATTGAATGGACAAGCTTGACCAGTTTCCTTTCTTTTGCTGCTTCGACCCCAAA
  CAACATGGGGTTAGTAAGAAATGAACTTCAGCTGGTTGATCTCCCAACAGGGAGGAGCACTGCTTTCCGT
  GGTGACCGGGGCAATGACGAATCACCCATTGAAATGATCAAAGTGTCTCATCTGAAACAGTATTTGGCAG
  TTGTTTTCAAAGATAAGCCCCTGGAATTATGGGATATTAGAACTTGCACTCTTCTTAGAGAAATGTCTAA
  AAGTTTCCCTGCTATAACTGCATTGGAGTGGTCACCATCTCACAACCTGAAGAGCCTGAGAAAGAAGCAG
  CTTGCCACCCGGGAGGCCATGGCCCGCCAGACTGTGGTCTCCGATGCAGAGCTGGGTGCTGTTGAATCAT
  CTGTGATCAGTTTATTACAGGAGGCAGAGAGTAAGGCTGAACTCAGTCAGAACATCTCTGCTCGGGAGCA
  TTTTGTGTTTACTGACAATGATGGCCAAGTTTATCATCTCACTGTTGAAGGAAATTCTGTGAAAGACAGT
  GCTCGGATTCCACCAGATGGTAGCATGGGCAGTATTACCTGCATCGCTTGGAAGGGGGATACATTAGTGC
  TTGGAGATATGGATGGAAATTTAAACTTCTGGGATTTGAAAGCCAGAGTATCCAGAGGAATACCCACACA
  TAGAAGTTGGGTGAGGAAGATTCGCTTTGCCCCCGGCAAGGGAAACCAGAAGCTAATAGCAATGTATAAT
  GATGGTGCTGAAGTGTGGGATACTAAAGAGGTTCAGATGGTGAGCAGTTTAAGAAGTGGAAGAAATGTAA
  CCTTCCGGATTTTGGATGTGGACTGGTGCACATCAGATAAGGTGATCTTGGCATCTGATGACGGCTGCAT
  CAGAGTCCTGGAGATGTCAATGAAGTCTACGTGTTTCAGAATGGATGAGCAGGAGTTAGTAGAGCCTGTG
  TGGTGCCCGTACCTCCTTGTTCCGAGGGCTGCCCTTGCTTTGAAAGCCTTCCTACTGCATCAGCCTTGGA
  ATGGGCGATATTCGTTGGACATTTCTCACATTGATTATCCAGAAAATGAAGAAATAAAGACTCTCCTTCA
  AGAACAGTTGCATGCATTGTCTAACGACATAAAGAAACTCCTGCTTGATCCCGACTTCTCTCTCTTGCAG
  AGGTGCCTGCTCGTGTCCAGGCTGTACGGCGATGAATCGGAGCTGCACTTCTGGACAGTGGCGGCCCACT
  ACCTGCACAGCTTGTCCCAGGCCAAGTCTGGGGACACAGTGGTAACCAAGGAAGGTGCTCCTAAGGACAG
  GCTGAGCAACCCATTGGACATCTGCTACGATGTGCTCTGTGAGAACACCTACTTCCAGAAATTTCAGCTA
  GAAAGAGTTAATCTACAGGAAGTAAAACGGTCAACTTATGATCACACGAGAAAGTGCACAGACCAGCTCC
  TGCTGCTAGGCCAGACAGACAGAGCTGTGCAGCTGCTGTTGGAAACAAGTGCAGATAACCAGCACTACTA
  CTGCGACTCTCTGAAAGCTTGCTTGGTCACCACTGTCACCTCTTCAGGCCCTTCTCAGAGCACAATTAAG
  CTGGTAGCAACCAATATGATCGCCAATGGCAAGCTGGCAGAGGGTGTTCAGTTACTCTGCTTGATAGACA
  AGGCTGCGGACGCCTGTCGCTACCTGCAGACGTATGGCGAGTGGAATCGGGCGGCATGGCTTGCAAAGGT
  TCGGTTAAATTCTGAAGAATGTGCAGATGTTCTGAAGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTC
  AACCAGAAGTCCAAGGCCCTCCTGGTCCTCCTCTCTCTGGGTTGCTTTGTCAGCGTGGCAGAGACGCTTC
  ACAGCATGAGATACTTCGATAGAGCTGCCTTGTTTGTGGAAGCCTGTCTCAAGTACGGTGCATTTGAAGT
  CAGTGAGGACACAGAGAAGCTCATTGCTGCCATCTACGCAGACTATGCCCGGAGCCTGAAGAGCCTCGGC
  TTTAGACAGGGAGCAGTGCGTTTTGCTTCAAAAGCTGGAGCGGCTGGCAGAGATTTGTTGAATGAGCTTG
  GGTCCACCAAGGAAGAGCTAACGGAAAGTTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_172255
• Insert Size: 3672 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_172255.3, NP_758459.2
• RefSeq Size: 4566 bp
• RefSeq ORF: 3672 bp
• Locus ID: 207425
• UniProt ID: Q8K1X1
• Cytogenetics: 7 F3
• Gene Summary: Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (By similarity).[UniProtKB/Swiss-Prot Function]