Xpo5 (NM_028198) Mouse Untagged Clone
$1,154.00
6 Weeks*
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
|---|---|
| Target Symbol | Xpo5 |
| Synonyms | 2410004H11Rik; 2700038C24Rik; AI648907; AW549301; Exp5; mKIAA1291; RanBp21 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | SgfI-MluI | |
| ACCN | NM_028198 |
| Insert Size | 3615 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_028198.2, NP_082474.1 |
| RefSeq Size | 3709 bp |
| RefSeq ORF | 3615 bp |
| Locus ID | 72322 |
| UniProt ID | Q924C1 |
| Cytogenetics | 17 C |
| Summary | Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi) (By similarity). Mediates nuclear export of ADAR/ADAR1 in a RanGTP-dependent manner (By similarity).UniProtKB/Swiss-Prot Function |
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Resources
"NM_028198" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MG225052 | Xpo5 (tGFP-tagged) - Mouse exportin 5 (Xpo5), (10ug) | 10 ug |
$1,248.00
|
|
| MR225052 | Xpo5 (Myc-DDK-tagged) - Mouse exportin 5 (Xpo5) | 10 ug |
$589.00
$1,048.00
|
|
| MR225052L3 | Lenti ORF clone of Xpo5 (Myc-DDK-tagged) - Mouse exportin 5 (Xpo5) | 10 ug |
$1,348.00
|
|
| MR225052L4 | Lenti ORF clone of Xpo5 (mGFP-tagged) - Mouse exportin 5 (Xpo5) | 10 ug |
$1,348.00
|
|
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.