Tyk2 (NM_018793) Mouse Untagged Clone

CAT#: MC223847

Tyk2 (untagged) - Mouse tyrosine kinase 2 (Tyk2), transcript variant 2, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Tyk2
• Synonyms: JTK1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC223847 representing NM_018793
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGTGGGGACCATGCCTCTGTGTGGGCGGAGAGCCATCTTGGAAGACAGCAAGGCAGATGGCACAGAAG
  CTCAGCCCCTGGTGCCCACAGGATGCTTGATGGTGCTACTGCATTGGCCTGGGCCTGAGGGCGGGGAGCC
  CTGGGTCACCTTCAGCCAGACATCTCTGACTGCAGAGGAGGTCTGCATCCACATCGCACACAAAGTCGGC
  ATCACTCCACCCTGCTTGAATCTCTTCGCACTCTACAATGCACAGGCTAAGGTCTGGCTGCCCCCAAACC
  ATATTCTGGATACATCCCAAGACATGAACCTCTATTTTCGAATGAGGTTTTACTTCCGGAACTGGCATGG
  CATGAATCCCCAGGAGCCAGCTGTATACCGGTGTGGTTTCCCAGGGGCAGAGACTTCCTCAGACCGGGCA
  GAGCAAGGTGTACAGCTCTTGGACTCTGCCTCGTTTGAATACCTTTTTGAGCAGGGAAAGCATGAGTTCA
  TGAACGATGTGGTGTCTCTGCGGGACCTGTCTAGCGAGGAGGAGATCCACCACTTTAAGAATGAGAGCTT
  AGGCATGGCCTTCCTGCACCTGTGTCACCTTGCTCTCAGCCGAGGCGTCCCCCTGGAGGAGATGGCCAGA
  GAGATCAGCTTCAAGAACTGCATCCCTCATTCCTTCCGACAGCACATCCGGCAGCACAATGTGCTCACAC
  GCCTGCGGCTCCACAGAGTCTTCCGCCGCTTCCTGCGGGCCTTCCGGCCTGGCCACCTCTCCCAGCAGGT
  TGTGATGGTGAAGTACTTGGCTACCCTGGAGCGGCTGGCTCCGCGCTTTGGCTCAGAGCGCATACCTGTG
  TGTCATCTGGAGGTCCTGGCACAGCCCGAGAGGGACCCCTGCTACATCCAGAACAGTGGGCAGACCGCTG
  GGGATCCAGGCCCAGAGCTGCCTTCCGGGCCTCCCACCCACGAGGTACTGGTGACAGGCACCGGAGGTAT
  CCAGTGGCATCCGCTGCAGACCCAGGAATCTGAGAGAGGTAACAGCAGAGGGAATCCCCACGGCAGCCGG
  TCGGGGAAGAAGCCCAAAGCCCCCAAGGCTGGAGAGCACCTGACAGAGAGCCCTCAGGAACCACCTTGGA
  CCTACTTCTGTGACTTCCAGGACATTTCCCACGTGGTGCTAAAGGAGCGTCGCGTGCACATCCACCTCCA
  AGACAACAAGTGCTTGTTGCTGTGCCTCTGTTCCCAGGCTGAGGCCCTGTCCTTTGTGGCCCTGGTCGAT
  GGCTATTTCCGCTTGACTGCTGACTCCAGCCACTATCTGTGCCATGAGGTGGCACCCCCGAGGCTGGTGA
  CTAGCATCCAGAACGGCATCCATGGGCCCCTGATGGATCCGTTTGTACAGGCCAAGCTGTGGCCAGAGGA
  CGGCCTCTACCTGATTCAGTGGAGCACCAGCCACCTGCACCGCCTGATCCTTACCGTGGCCCATCGAAAC
  CCGGCTTTCAGTAATGGCCCTCGGGGCCTGCGCCTGCGAAAGTTCCCCATCACACAGCAGCCTGGAGCCT
  TTGTGCTGGATGGCTGGGGCCGCTCCTTTGCCAGCTTGGGGGACCTTCGGCTCGCCTTGCAGGGCTGCTC
  GTTGCGGGCCGGTGATGACTGTTTCCCCCTGCACCACTGCTGCCTGCCCCGGCCAAGAGAAATCTCCAAC
  CTCGTCATCATGCGGGGGTCTAGGGCCCACACCCGGCCTCTCAACCTCAGTCAGCTCAGCTTCCACAGGG
  TTCACCAGGATGAAATCACCCAGCTGTCCCACTTGGGCCAAGGCACAAGGACCAATGTGTATGAGGGCCT
  TCTAAGAGTGGGAGGCCCCGATGAGGGCAAAGTGGACAATGGATGTCCCCCTGAGCCTGGTGGGACTAGT
  GGGCAGCAGCTTCGAGTGGTGCTCAAAGTTCTCGACCCCAGTCACCATGATATCGCCTTGGCCTTCTATG
  AGACTGCTAGCCTCATGAGCCAGGTGTCACACATGCACCTGGCTTTCCTGCATGGTGTTTGCGTGCGTGG
  CTCAGAGAATATCATTGTGACAGAATTCGTAGAACATGGTCCCTTGGATGTGTGGTTACGGCGACAGAGG
  GGCCAAGTGCCCATGACCTGGAAGATGGTCGTGGCTCAGCAGCTGGCCAGCGCCCTCAGCTACCTGGAGG
  ACAAGAATCTGGTTCACGGGAATGTATGTGGCCGGAACATCCTGCTGGCTCGCCTGGGGTTGGAGGAGGG
  TACCAACCCCTTCATCAAGCTAAGTGATCCTGGTGTGGGCCAGGGTGCCCTCTCCAGGGAAGAGCGGGTG
  GAGCGCATCCCCTGGACAGCTCCCGAGTGCCTGTCTGGAGGGACCAGTAGCTTGGGTACTGCCACGGACA
  TGTGGGGCTTTGGTGCCACCCTTCTTGAGATCTGCTTTGATGGGGAGGCACCCCTGCAGGGTCGTGGTCC
  CTCTGAGAAAGAACGGTTCTACACAAAGAAACATCAGCTGCCTGAACCCTCATCCCCAGAGCTGGCCACA
  CTCACCCGCCAGTGCCTGACCTATGAACCAGCACAGCGGCCATCCTTCCGCACCATTTTGCGGGACCTCA
  CAAGGCTGCAGCCACAGAATCTAGTCGGCACTTCGGCTGTGAACTCAGACTCACCAGCATCAGACCCCAC
  TGTTTTCCACAAGCGCTATTTGAAAAAGATCCGGGATTTGGGTGAGGGTCACTTTGGCAAGGTCAGCCTG
  TACTGCTACGACCCAACCAATGACGGCACTGGCGAGATGGTGGCCGTGAAGGCCCTGAAGGAAGGGTGCG
  GTCCCCAGCTCCGCTCAGGCTGGCAGCGGGAGATCGAGATCCTGCGGACGCTGTACCACGAACATATTGT
  CAAGTATAAAGGCTGCTGTGAGGACCAAGGAGAGAAGTCTGTACAGCTGGTCATGGAGTACGTCCCTCTG
  GGCAGCCTCCGAGACTACCTGCCAAGGCACTGCGTAGGGCTGGCGCAGCTCCTGCTGTTTGCCCAGCAGA
  TCTGCGAGGGCATGGCCTACCTGCACGCTCAGCACTACATTCACCGAGACCTCGCCGCGCGCAACGTGCT
  GCTGGACAACGACAGGCTGGTCAAGATTGGAGACTTTGGCCTAGCCAAGGCTGTACCTGAAGGCCACGAG
  TACTACCGAGTGCGCGAGGACGGGGACAGCCCAGTGTTCTGGTATGCCCCAGAATGCCTGAAGGAGTGCA
  AATTTTACTATGCATCTGATGTCTGGTCCTTCGGGGTAACTCTGTATGAGTTGTTGACATACTGTGACTC
  TAACCAGAGTCCCCATATGAAATTCACCGAGCTCATCGGCCATACCCAGGGCCAGATGACCGTGCTGAGG
  CTCACAGAGCTGCTGGAACGAGGAGAGAGGCTGCCTCGGCCTGACAGGTGTCCCTGTGAGATCTATCACC
  TCATGAAGAACTGCTGGGAGACAGAGGCCTCCTTCCGGCCCACCTTCCAGAATCTTGTGCCCATCCTCCA
  GACAGCACAGGAGAAGTACCAAGGTCAGGTGCCTTCCGTGTTCAGCGTGTGCTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_018793
• Insert Size: 3555 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_018793.2, NP_061263.2
• RefSeq Size: 4822 bp
• RefSeq ORF: 3555 bp
• Locus ID: 54721
• UniProt ID: Q9R117
• Cytogenetics: 9 A3
• Gene Summary: Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities.[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.