Adcy6 (NM_007405) Mouse Untagged Clone

CAT#: MC223787

Adcy6 (untagged) - Mouse adenylate cyclase 6 (Adcy6), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Adcy6
• Synonyms: AC6; mKIAA0422
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC223787 representing NM_007405
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGTCATGGTTTAGTGGCCTCCTGGTTCCCAAAGTGGATGAACGGAAAACAGCTTGGGGGGAACGCAATG
  GGCAGAAGCGCCCACGCCACGCGAATCGAGCCAGTGGCTTCTGCGCACCTCGCTACATGAGCTGCCTCAA
  GAATGCGGAGCCACCCAGCCCCACTCCTGCAGCTCACACTCGGTGCCCCTGGCAGGATGAAGCCTTCATC
  AGGAGGGCGGGCCCGGGCAGGGGTGTGGAGCTGGGGCTGCGGTCAGTGGCCTTGGGGTTTGACGACACTG
  AGGTGACCACACCGATGGGCACAGCTGAAGTGGCACCGGATACATCGCCTCGGAGCGGTCCGTCCTGCTG
  GCACCGGCTTGTGCAGGTGTTCCAGTCTAAGCAGTTCCGCTCTGCCAAGCTGGAGCGGCTGTACCAGCGG
  TACTTCTTCCAGATGAACCAGAGCAGCCTCACGCTGCTCATGGCGGTGCTGGTGCTGCTCATGGCTGTAC
  TGTTGACTTTCCACGCTGCGCCTGCCCAGCCTCAGCCTGCTTACGTGGCCCTGCTGACCTGTGCCTCTGT
  CCTTTTTGTGGTACTCATGGTGGTGTGTAACCGACACAGCTTCCGCCAGGACTCCATGTGGGTGGTGAGC
  TATGTGGTCCTGGGCATCCTAGCAGCCGTGCAAGTCGGGGGTGCCCTGGCAGCCAATCCACACAGCCCCT
  CGGCGGGCCTTTGGTGCCCCGTGTTCTTCGTCTACATCACCTACACTCTTCTTCCCATTCGCATGCGAGC
  CGCAGTACTCAGCGGCCTGGGCCTCTCTACTCTGCATTTGATTTTGGCCTGGCAGCTCAACAGCAGCGAC
  CCCTTCCTTTGGAAGCAGCTCGGTGCTAACGTGGTGCTCTTCCTCTGCACCAATGCCATCGGTGTCTGCA
  CACACTACCCTGCTGAAGTGTCTCAGCGCCAAGCCTTTCAGGAGACCCGAGGTTACATCCAGGCGCGGCT
  GCACCTGCAGCATGAGAACCGTCAGCAGGAACGGCTGCTGCTATCGGTGTTGCCCCAGCACGTTGCCATG
  GAGATGAAAGAAGACATCAACACAAAAAAAGAGGACATGATGTTCCATAAGATCTACATCCAGAAGCATG
  ATAATGTCAGCATCCTGTTTGCGGACATTGAGGGCTTCACCAGCCTGGCCTCCCAGTGCACTGCACAGGA
  ACTGGTCATGACCTTGAATGAGCTCTTTGCCCGGTTTGACAAGCTGGCTGCGGTGAGGGAGAATCACTGT
  CTGAGGATCAAGATCTTAGGAGACTGTTACTACTGCGTGTCAGGGCTGCCCGAGGCCCGGGCAGATCACG
  CCCACTGCTGTGTGGAGATGGGGGTAGACATGATCGAAGCCATCTCGCTGGTGCGTGAGGTAACAGGTGT
  GAACGTGAACATGCGTGTGGGCATCCACAGCGGACGTGTGCATTGCGGCGTCCTTGGCCTACGGAAATGG
  CAGTTTGATGTCTGGTCAAACGATGTGACCCTGGCTAACCACATGGAGGCCGGGGGCCGGGCCGGCCGCA
  TCCACATCACTCGGGCTACACTGCAGTACTTGAACGGGGACTATGAGGTGGAGCCAGGCCGTGGTGGTGA
  ACGCAATGCGTACCTCAAGGAGCAGTGCATTGAGACCTTCCTCATACTTGGCGCCAGCCAAAAACGGAAA
  GAGGAGAAAGCCATGCTGGCCAAGCTTCAGCGGACACGGGCCAACTCCATGGAAGGACTGATGCCCCGCT
  GGGTTCCTGACCGTGCCTTCTCCCGGACCAAGGACTCTAAGGCATTCCGCCAGATGGGCATTGATGATTC
  TAGCAAAGACAACCGGGGTGCCCAAGATGCTCTGAACCCTGAAGATGAGGTGGATGAGTTCCTGGGCCGA
  GCCATCGATGCCCGAAGCATCGACCAACTGCGTAAGGACCATGTGCGCCGGTTCCTGCTCACCTTCCAGA
  GAGAGGATCTTGAGAAGAAGTATTCACGGAAAGTAGATCCTCGCTTCGGAGCCTACGTCGCCTGTGCCCT
  CCTGGTTTTTTGCTTCATCTGTTTTATCCAGCTCCTTGTGTTCCCATACTCCACCCTGATACTCGGGATT
  TATGCCGCTATCTTCCTGCTGTTGCTGGTCACTGTGCTGATCTGTGCCGTGTGCTCCTGCGGTTCTTTCT
  TCCCCAAGGCCCTGCAACGCCTGTCCCGCAATATTGTCCGCTCACGGGTGCACAGCACCGCGGTTGGAAT
  CTTCTCGGTTCTGCTTGTGTTCATCTCTGCCATCGCCAACATGTTTACCTGTAATCACACCCCAATAAGG
  ACCTGCGCGGCCCGGATGCTGAACTTAACACCAGCGGATGTCACCGCCTGCCACCTACAACAGCTCAATT
  ACTCTCTGGGACTGGATGCTCCCCTGTGTGAGGGCACCGCACCCACCTGCAGCTTCCCTGAGTACTTCGT
  CGGGAACGTGCTGCTGAGTCTTCTAGCCAGCTCTGTCTTCCTACACATCAGCAGCATCGGCAAGCTGGCC
  ATGACCTTCATCTTGGGGTTCACCTACTTGGTGCTGCTTTTGCTGGGTCCCCCGGCCGCCATCTTTGACA
  ACTATGATCTACTGCTTGGCGTCCATGGCTTGGCTTCCTCCAATGAGACCTTTGATGGGCTGGACTGCCC
  AGCTGTGGGGAGGGTAGCGCTCAAATATATGACCCCCGTGATTCTGCTGGTGTTTGCCCTGGCACTGTAT
  CTGCATGCACAACAGGTGGAATCGACTGCCCGCCTGGACTTCCTGTGGAAGTTACAGGCAACAGGGGAGA
  AGGAGGAGATGGAGGAGCTACAGGCATACAACCGGAGGTTGCTGCATAACATTCTTCCCAAGGACGTGGC
  CGCCCACTTCCTGGCCCGGGAACGCCGCAACGATGAGCTGTACTACCAGTCGTGTGAATGTGTGGCTGTC
  ATGTTTGCCTCCATCGCCAATTTCTCGGAGTTCTACGTGGAGCTCGAGGCAAACAACGAGGGCGTGGAGT
  GCCTGCGGCTGCTCAATGAGATCATCGCAGACTTTGACGAGATCATCAGTGAGGAGAGATTCCGGCAGTT
  GGAGAAGATCAAGACCATCGGTAGCACCTACATGGCCGCCTCTGGGCTAAATGCCAGCACCTATGACCAG
  GTCGGCCGCTCACACATCACGGCGCTGGCTGACTATGCCATGCGGCTCATGGAGCAGATGAAACACATCA
  ATGAACACTCTTTCAACAATTTCCAGATGAAGATCGGGTTGAACATGGGTCCGGTTGTAGCAGGCGTCAT
  TGGGGCCCGAAAGCCACAGTATGACATCTGGGGAAATACCGTGAATGTTTCCAGTCGTATGGACAGCACT
  GGAGTTCCTGACCGAATACAGGTGACTACGGACCTATACCAGGTTCTAGCTGCCAAGGGCTACCAGCTGG
  AGTGTCGAGGGGTGGTCAAGGTGAAGGGAAAGGGGGAGATGACCACCTACTTCCTCAACGGGGGCCCCAG
  CAGTTAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_007405
• Insert Size: 3507 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_007405.2, NP_031431.2
• RefSeq Size: 6038 bp
• RefSeq ORF: 3507 bp
• Locus ID: 11512
• UniProt ID: Q01341
• Cytogenetics: 15 F1
• Gene Summary: Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:18071070, PubMed:24363043). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:18071070). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption (PubMed:20466003, PubMed:20864687). Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion (PubMed:24854272). Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (PubMed:23753526). Signaling mediates cAMP-dependent activation of protein kinase PKA and promotes increased phosphorylation of various proteins, including AKT (PubMed:18071070, PubMed:23753526). Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility (PubMed:18071070). May contribute to normal heart function (PubMed:18071070, PubMed:20359598). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (By similarity). Contributes to bone cell responses to mechanical stimuli (PubMed:20371630, PubMed:24277577).[UniProtKB/Swiss-Prot Function]