Sorcs2 (NM_030889) Mouse Untagged Clone

CAT#: MC223772

Sorcs2 (untagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Sorcs2
• Synonyms: mKIAA1329; N28137
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC223772 representing NM_030889
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  CTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCCGGCGC
  GCCC
  
  ATGGCGCACCGGGGACCCCCGAGCGCCCCGAAGCGTCCTGGCCCTACTGCGCCGGACCGGAGCTTTCAGG
  CTCTGCTGCCGCCGTGCTGGCCACGTTCGTGGCCGCTGCTGCTGCTGCTGCTGGTGCTGGTGGCTGCCTG
  CGGAGCGATGGGGCGCTCCCCCCAGCCCGGGCGCCAGGGTCCCGGTGTGCAGATCACTAGGCTGCTGCCC
  GCGGGACGCACGGAGTCCGGCGATCGCAAAGATCCACAGGCACGAGAATCAGAACCCAGCGTCCCGGGTC
  TCGGTCCGGGTTCTGCTTCGGGTCCCAGCACCGATGGCGCCCCAGCTCCGGGCAAGGGGCGCAGGGCTCG
  GGCGGTGCCGGTGGCCGGTGCGGCTTCGGCTTCGCGCGCACAGGTCTCGCTCATCAGCACGTCGTTCGTG
  CTCAAGGGAGACGCGACGCACAACCAGGCGATGGTACACTGGACAGGAGAGAACAGCAGCGTCATCTTGA
  TCCTGACAAAGTACTACCATGCAGACATGGGCAAGGTTCTGGAAAGTTCTCTGTGGAGGTCCTCAGATTT
  TGGGACAACCTACACCAAGCTTACTCTCCAGCCTGGTGTCACCACTGTCATTGACAACTTCTATATCTGC
  CCAGCTAACAAAAGGAAGATCATCCTGGTGAGCTCATCCCTCGGTGACCGGGAACAGAGCCTCTTCCTCA
  GCACTGATGAGGGCGCCACGTTCCAGAAGTATCCTGTCCCCTTCCTTGTGGAGATGCTCCTCTTCCACCC
  GAAGGAGGAGGACAAGGTGCTGGCCTACACCAAGGACAGCAAGCTGTATGTGTCATCGGACCTGGGAAAG
  AAGTGGACACTTCTGCAGGAACGGGTGACCAAGGACCACGTGTTCTGGGCTGTGTCTGGGGTGGATGACG
  ACCCAAACTTGGTCCACGTGGAAGCTCAGGACCTCAGTGGAGGCTATCGGTACTACACGTGTCTGATCTA
  CAACTGCTCAGCCCAGCCACACATAGCACCCTTCTCCGGCCCCATTGACCGCGGGTCCCTGACCGTGCAG
  GATGAGTACATCTTTTTGAAGGCAACATCAACAAACCGAACCAAGTACTATGTCTCCTATCGCCGAAGTG
  ACTTTGTCCTGATGAAGCTGCCCAAGTATGCCCTGCCCAAGGACCTACAGATCATCAGCACGGATGAGCA
  GCAGGTGTTTGTGGCCGTACAGGAGTGGAACCAGGTAGACACCTACAACCTGTACCAGTCAGACCTGCGT
  GGGGTTCGCTATTCCCTGGTGCTGGAGAATGTGCGCAGCTCGAGGCAAGCCGAGGAGAACGTGGTCATCG
  ACATCCTTGAGGTCAGAGGGGTGAAGGGAGTCTTCTTGGCAAACCAGAAAGTGGATGGCAAGGTGACCAC
  AGTCATAACCTACAACAAGGGCCGTGACTGGGATTACCTGAGGCCACCCAGCACCGACATGAATGGGAAG
  CCCACCAACTGCCAGCCGCCGGACTGTTACCTGCACCTGCACTTGCGGTGGGCAGACAACCCCTATGTGT
  CAGGCACGGTACACACCAAGGACACTGCCCCTGGTCTCATCATGGGTGCAGGTAACCTGGGCTCACAGCT
  GGTGGAGTATAAAGAGGAGATGTACATCACATCTGACTGCGGGCACACCTGGAGGCAGGTCTTTGAGGAA
  GAGCACCATGTGTTGTACCTGGACCACGGTGGTGTCATTGCCGCCATCAAGGACACCTCCATCCCCCTGA
  AGATCCTCAAGTTCAGCGTGGATGAGGGCCACACGTGGAGCACACACAACTTCACCAGCACCTCAGTGTT
  CGTGGATGGGTTGCTGAGCGAGCCAGGGGATGAGACGCTGGTCATGACGGTCTTTGGTCACATCAGCTTC
  CGCTCTGACTGGGAGCTGGTCAAGGTTGACTTCCGGCCCTCCTTCCCCCGGCAGTGTGGCGAGGATGACT
  ACAGCTCCTGGGACCTCACTGACCTCCAGGGTGATCACTGCATCATGGGCCAACAGAGAAGTTACCGGAA
  GAGAAAGTCCACATCCTGGTGTGTCAAGGGACGGAGCTTCACATCAGCACTCACGTCACGTGTGTGCAAG
  TGCCGGGACTCCGACTTCCTCTGTGACTACGGGTTTGAGCGCTCATCTTCCTCGGAGTCCACTGCCAACA
  AGTGCTCTGCCAACTTCTGGTTCAACCCTTTGTCTCCTCCTGAAGACTGTGTCTTGGGTCAGACTTACAC
  TAGTAGCCTTGGGTACCGGAAGGTGGTGTCCAATGTGTGTGAAGGTGGTGTGGACCTGCAGCAGAGCCCA
  GTGCAGCTGCAGTGCCCCCTCCAGGCACCCCGGGGCCTGCAGGTGAGCATCCGAGGAGAGGCAGTGGCCG
  TGCGGCCTAGAGAAGATGTGCTGTTTGTGGTGCGACAGGAACAGGGTGATGTCCTGACCACTAAATATCA
  GGTGGATCTTGGGGATGGCTTCAAGGCCATGTACGTGAACCTCACTCTGACAGGCGAGCCCATTCGACAT
  CACTATGAGAGTCCTGGCATCTACCGAGTGTCCGTCAGGGCTGAGAACATGGCAGGCCATGATGAGGCTG
  TGCTCTTTGTCCAGGTCAACTCTCCCCTGCAGGCCCTCTACCTCGAGGTAGTTCCTGTCATTGGCGTCAA
  CCAGGAGGTGAACCTCACAGCCGTGCTGTTACCCCTGAATCCCAACCTCACTGTCTTCTACTGGTGGATC
  GGCCACAGCTTGCAGCCTCTGCTTTCCTTGGACAACTCGGTGACAACAAAGTTTACGGACGCTGGGGATG
  TGCGTGTGACAGTGCAAGCTGCCTGCGGGAACTCAGTGCTTCAGGACTCCAGGCTCGTCCGTGTGCTCGA
  TCAGTTCCAGGTGGTGCCTCTGCGGTTCTCCAGGGAGCTGGACACCTTTAACCCCAACACTCCTGAATGG
  AGGGAAGATGTGGGACTGGTGGTCACCCGACTGCTCTCCAAGGAGACCAGCATCCCAGAGGAGCTGCTTG
  TGACTGTGGTAAAGCCAGGGCTGCCCACCATAGCCGACTTGTATGTGCTTCTGCCTCTGCCAAGGCCCAC
  AAGGAAGAGGAGCCTCACAAGTGACAAGAGACTGGCAGCCGTGCAGCAGGCGCTGAACTCTCATAGAATC
  AGCTTCATCCTTCGAGGAGGGCTTCGTATCCTGGTGGAGCTGAGGGACACAGACACAGGTCCTCAGAGGC
  CAGGTGGCAGTGGTGGCTACTGGGCCGTGGTGGTCCTCTTTGTCATTGGGCTCTTTGCAGTAGGAGCATT
  CATCCTCTACAAGTTCAAAAGGAAACGTCCAGGCAGGACAGTGTACGCCCAGATGCACAATGAGAAGGAA
  CAGGAGATGACAAGTCCCGTGAGTCACAGTGAGGATGCCCAGAGCACCATGCAGGGCAACCACTCAGGGG
  TGGTCCTGAGCATCAACTCTCGTGAGATGCATAGCTACCTGGTGGGCTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: AscI-MluI
• ACCN: NM_030889
• Insert Size: 3480 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_030889.2, NP_112151.2
• RefSeq Size: 5722 bp
• RefSeq ORF: 3480 bp
• Locus ID: 81840
• UniProt ID: Q9EPR5
• Cytogenetics: 5 B3
• Gene Summary: The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487, PubMed:27457814, PubMed:29909994). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (PubMed:29909994). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814, PubMed:29909994). Plays a role in BDNF-dependent hippocampal synaptic plasticity (PubMed:29909994, PubMed:27457814). Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (By similarity). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes (PubMed:28469074). Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (PubMed:30840898).[UniProtKB/Swiss-Prot Function]