Trp53bp2 (NM_173378) Mouse Untagged Clone

CAT#: MC223694

Trp53bp2 (untagged) - Mouse transformation related protein 53 binding protein 2 (Trp53bp2), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Trp53bp2
• Synonyms: 53BP2; AI746547; ASPP2; PPP1R13A; Tp53bp2; X98550
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC223694 representing NM_173378
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCGGTTCGGGTCCAAAATGATGCCGATGTTCCTGACAGTTTACCTCAGTAACAGTGAGCAGCACTTCA
  CAGAAGTTCCTGTTACCCCAGAGACAATATGCAGAGATGTGGTGGATCTGTGCAAGGAGCCTGGAGAGAA
  CGACTGCCATTTAGCCGAAGTGTGGTGTGGCTCTGAACGCCCAGTTGCTGATAACGAACGGATGTTTGAT
  GTTCTTCAGCGGTTTGGAAGTCAAAGGAATGAAGTTCGCTTCTTTCTTCGTCATGAACGCCCCCCTAACA
  GGGACATTGTGAGTGGACCGAGATCCCAAGATCCAAGTGTAAAAAGAAATGGTGTCAAAGTTCCCGGCGA
  GCATCGGAGGAAGGAGAATGGGGTTAACAGTCCTAGGCTGGACCTGACGCTTGCTGAGCTCCAGGAGATG
  GCATCTCGCCAGCAGCAGCAGATCGAGGCCCAGCAACAAATGCTGGCTACTAAGGAGCAACGCTTAAAGT
  TTTTAAAACAGCAAGATCAACGTCAACAGCAACAAGCTGCTGAACAGGAGAAACTTAAGAGGCTTAGAGA
  AATAGCTGAAAGTCAGGAAGCTAAGCTTAAGAAAGTGAGAGCGCTAAAGGGCCATGTGGAGCAAAAGAGG
  CTGAGCAACGGAAAACTCGTGGAGGAGATCGAGCAGATGAATAGCTTGTTCCAGCAGAAGCAGAGGGAGC
  TGGTGCTGGCTGTGTCGAAAGTGGAGGAGCTGACGAGGCAGCTGGAGATGCTGAAGAACGGCAGGATCGA
  TGGCCACCACGACAACCAGTCGGCCGTGGCTGAGCTGGACCGCCTTTACAAGGAGCTGCAGTTAAGAAAC
  AAACTGAACCAAGAGCAGAATGCCAAGCTGCAACAACAGAGGGAGTGTTTGAATAAGCGCAATTCAGAGG
  TGGCCGTCATGGATAAACGCGTCAGTGAGCTGAGGGACCGGCTGTGGAAGAAGAAGGCAGCACTGCAGCA
  GAAAGAGAATCTCCCGGTTTCACCTGATGGAAATCTTCCCCAACAAGCAGTGTCAGCCCCAAGTCGTGTG
  GCTGCTGTAGGCCCTTACATCCAGTCATCCACTATGCCACGGATGCCCTCCAGACCTGAGCTGCTCGTGA
  AGCCAGCCCTGCCTGATGGTTCCTTGCTCATGCAGTCAGCAGAGGGGCCAATGAAGATACAGACACTGCC
  CAATATGAGGTCTGGGGCTGCTTCACAAAGTAAAGGCTCTAAAGCTCACCCAGCTAGCCCCGATTGGAAC
  CCTTCCAATGCCGACCTCTTACCCAGCCAAGGCTCTTCTGTACCCCAGAGTGCTGGAACTGCTCTGGACC
  AAGTTGACGATGGGGAGATTGCTGTGAGGGAGAAAGAGAAGAAAGTGCGTCCCTTTTCCATGTTTGACAC
  AGTGGACCAGTGTGCTGCCCCACCCTCCTTTGGTACCCTGAGGAAAAACCAGAGCAGCGAGGACATCTTG
  CGGGATGCTCAGGCTGTAAATAAAAATGTAGCTAAAGTACCACCTCCCGTTCCTACAAAGCCAAAACAGA
  TTCATTTGCCTTACTTTGGACAAACGGCTCAGTCGCCTTCTGACATGAAGCCAGATGGAAATGCTCAGCA
  ATTGCCAATAGCTGCTACATCCGTGGGGGCTAAGCTCAAGCCAGCAGGGCCACAGGCAAGGATGCTGCTG
  TCTCCTGGTGCCCCTTCAGGTGGTCAGGACCAAGTCCTGTCTCCAGCATCTAAGCAAGAAAGTCCTCCTG
  CTGCTGCAGTCCGGCCCTTCACGCCCCAGCCGTCCAAGGACACCTTCCCTCCAGCCTTTCGAAAACCCCA
  GACTGTGGCAGCAAGCTCCATCTATTCCATGTACACCCAGCAACAGGCACCAGGAAAAAACTTCCAGCAG
  GCTGTGCAGAGTGCCTTGACCAAGACGCAACCCAGAGGCCCCCACTTTTCAAGTGTGTATGGCAAGCCTG
  TGATAGCTGCTGCCCAGAATCCACAACAGCACCCAGAGAACATTTACTCCTGTAGCCAGGGGAAGCCTGG
  CAGTCCGGAGCCCGAGACAGAGACCGTTTCTTCAGTTCATGAGAGCCATGAAAACGAAAGGATTCCTCGA
  CCACTCAGCCCAACAAAATTACTGCCTTTCTTGTCTAACCCTTATCGAAACCAGAGCGATGCTGACTTAG
  AAGCCCTGAGGAAAAAATTGTCGAATGCACCACGGCCACTAAAGAAACGTAGCTCCATTACAGAACCAGA
  AGGCCCTAATGGGCCAAATATTCAGAAACTTTTGTATCAGAGGACCACCATAGCTGCCATGGAGACCATC
  TCAGTCCCCTCACACCCATCTAAGTCACCAGGCTCAGTGACTGTCAATCCAGAGAGCTCCGTTGAAATCC
  CAAATCCATATTTACATGTGGAGCCAGAGAAGGAGGTGGGCTCTTTAGTCCCTGAACCACTGTCCCCAGA
  GGATATGGGGAGTGCCAGTACGGAGAACAGTGACGTGCCAGCTCCTTCTGCAGGCCTTGAGTATGTGTCT
  GAGGGAGTCACAGACAGCAGTACCAATCTGCAGAATAACGTAGAAGAAACAAACCCAGAGGCTCCCCACT
  TACTTGAAGTGTACCTAGAAGAATACCCCCCATACCCACCCCCTCCATACCCATCTGGGGAGCCAGAGGT
  GTCCGAAGAAGACTCCGCACGTATGCGCCCACCTGAAATCACCGGGCAGGTGTCTCTGCCTCCTGGCAAA
  AGGACAAACTTGCGGAAAACTGGCTCCGAGCGGATTGCTCACGGGATGAGGGTGAAATTCAACCCCCTTG
  CTTTGCTGCTAGATTCATCTCTGGAGGGAGAGTTTGATCTTGTACAGAGAATTATCTATGAGGTTGATGA
  CCCAAGCCTACCAAATGATGAGGGCATCACAGCTCTTCATAATGCTGTGTGTGCAGGCCACACAGAAATT
  GTGAAGTTCCTGGTACAGTTCGGTGTGAATGTAAATGCAGCAGATAGTGATGGATGGACGCCATTGCATT
  GTGCTGCCTCCTGCAACAATGTCCAAGTGTGTAAGTTCCTGGTGGAGTCTGGAGCAGCTGTGTTTGCTAT
  GACCTACAGTGACATGCAGACTGCTGCAGACAAGTGCGAGGAAATGGAGGAAGGCTACACGCAGTGCTCC
  CAGTTTCTCTATGGCGTTCAGGAGAAGATGGGCATAATGAACAAAGGCGTCATTTATGCACTGTGGGATT
  ACGAGCCGCAGCATGACGATGAGCTGCTCATGAAAGAAGGAGATTGCATGACCGTCATCCGCAGAGAAGA
  TGAAGAGGAGATCGAGTGGTGGTGGGCGCGCCTTAACGATAAGGAAGGATATGTTCCACGCAACTTGCTA
  GGACTATACCCAAGAATTAAACCAAGACAAAGGAGCTTGGCCTGA
  
  AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC
  TGGATTACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-RsrII
• ACCN: NM_173378
• Insert Size: 3405 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_173378.2, NP_775554.2
• RefSeq Size: 4377 bp
• RefSeq ORF: 3405 bp
• Locus ID: 209456
• UniProt ID: Q8CG79
• Cytogenetics: 1 84.93 cM
• Gene Summary: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 (By similarity).[UniProtKB/Swiss-Prot Function]