Wwc1 (NM_170779) Mouse Untagged Clone

CAT#: MC223597

Wwc1 (untagged) - Mouse WW, C2 and coiled-coil domain containing 1 (Wwc1), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Wwc1
• Synonyms: AA408228; AU017197; BC037006; Kibra; mKIAA0869
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC223597 representing NM_170779
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCCCCGGCCGGAGTTGCCCCTGCCGGAGGGCTGGGAGGAGGCGCGCGACTTCGACGGCAAGGTCTACT
  ACATAGATCACAGGAACCGCACCACCAGCTGGATCGACCCGCGGGACAGGTACACCAAACCACTCACCTT
  CGCTGACTGCATCAGTGATGAGTTACCGCTGGGATGGGAAGAAGCATACGACCCACAGGTCGGAGATTAC
  TTCATAGACCACAATACCAAAACCACTCAGATCGAGGATCCAAGGGTGCAATGGCGGCGGGAACAGGAGC
  ACATGCTGAAGGATTACCTGGTGGTGGCTCAGGAAGCTCTGAGTGCACAAAAGGAGATCTACCAGGTGAA
  GCAGCAGCGCCTGGAGCTGGCACAGCAGGAGTATCAGCAGTTGCATGCCGTCTGGGAGCATAAGCTGGGC
  TCCCAGGTTAGCTTGGTCTCTGGATCCTCGTCCAGCTCCAAGTATGACCCCGAGATCCTGAAAGCTGAAA
  TTGCCACTGCAAAGTCCCGGGTCAACAAGCTGAAGAGAGAGATGGTTCACCTACAGCATGAGCTGCAGTT
  CAAGGAGCGTGGCTTTCAGACGCTGAAGAAAATTGATGAGAGAATGTCAGACGCACAGGGTGGCTACAAA
  CTGGATGAGGCCCAGGCTGTGCTGAGGGAAACCAAAGCCATCAAGAAAGCCATCACCTGCGGAGAAAAGG
  AGAAACAAGACCTCATTAAGAGTCTCGCCATGCTGAAGGATGGCTTCCGGACAGACAGAGGGTCACACTC
  CGACCTATGGTCCAGCAGCAGCTCTCTGGAGAGTTCAAGCTTCCCGATGCCAAAGCAGTTCCTGGACGTG
  AGCTCGCAGACAGACATCTCTGGGAGTTTCAGCACCAGCAGCAACAATCAGTTGGCCGAGAAGGTCAGAT
  TGCGCCTTCGGTATGAAGAGGCGAAGAGAAGGATCGCCAACCTCAAGATCCAGCTGGCCAAACTTGACAG
  TGAGGCCTGGCCTGGGGTGCTAGACTCAGAGAGGGACCGACTGATCCTCATCAATGAGAAGGAGGAACTT
  CTGAAGGAAATGCGCTTCATCAGCCCCCGGAAATGGACCCAGGGAGAGGTGGAGCAACTGGAGATGGCCC
  GGAGGCGACTTGAGAAGGACTTACAGGCAGCCCGGGACACCCAGAGCAAGGCGCTGACTGAGAGGCTGAA
  GTTAAATAGCAAGAGGAACCAGCTGGTGCGAGAACTGGAGGAAGCCACTCGGCAGGTGGCTACCCTGCAC
  TCCCAGTTGAAAAGCCTCTCAAGCAGCATGCAGTCCCTGTCTTCAGGCAGTAGCCCTGGGTCACTCACCT
  CCAGCCGGGGCTCCCTGGCCGCCTCTAGCCTGGACTCCTCCACCTCAGCCAGCTTCACTGACCTCTATTA
  TGACCCGTTCGAGCAGTTGGACTCGGAGCTCCAGAGCAAGGTGGAGCTGCTGTTCCTGGAGGGTGCCACG
  GGCTTCCGGCCCTCAGGCTGCATCACCACCATCCACGAGGATGAGGTGGCCAAGACCCAGAAGGCAGAGG
  GAGGCAGCCGCCTGCAGGCCCTGCGCTCCCTATCTGGCACTCCAAGGTCCATGACCTCCCTGTCTCCACG
  CTCATCTCTCTCCTCCCCATCCCCTCCCTGTTCCCCTCTCATCACTGATCCCCTCCTGACTGGAGATGCC
  TTCCTGGCCCCGCTGGAGTTTGAAGACACAGAGCTGAGTACCACTCTCTGTGAGCTGAACCTCGGCGGTA
  GCGGCACCCAGGAAAGATACCGGCTGGAGGAACCAGGACCTGAGGGCAAGCCACTGGGCCAAGCTGCAAG
  TGTGGCCCCAGGATGTGGCCTCAAAGTAGCCTGTGTGTCCGCTGCAGTGTCCGACGAGTCAGTAGCCGGG
  GACAGTGGCGTGTATGAGGCTTCAGCACAGAGACCAGGTACTTCTGAAGCTGCCGCATTCGACAGTGATG
  AATCGGAAGCTGTGGGTGCCACTCGGGTTCAGATTGCCCTGAAATATGATGAGAAGAATAAGCAATTTGC
  AATATTAATCATTCAGCTGAGTCACCTCTCTGCTCTGTCACTACAACAAGACCAGAAAGTGAACATCCGT
  GTAGCCATCCTGCCTTGCTCTGAAAGCAGCACCTGCTTGTTCAGAACCCGGCCTCTGGACTCGGCAAATA
  CCCTCGTGTTCAATGAGGCATTCTGGGTGTCCATCTCCTACCCAGCCCTTCACCAAAAGACCTTACGAGT
  CGATGTCTGCACCACTGACAGGAGCCATACAGAGGAGTGTCTGGGAGGTGCCCAGATCAGCCTGGCCGAG
  GTCTGCCGGTCTGGGGAGAGGTCAACGCGCTGGTACAATCTCCTGAGCTACAAATACTTGAAGAAGCAGT
  GCAGGGAGCCCCAGCCAACAGAAGCTCCAGGGCCAGACCATGTGGACGCTGTGTCTGCCTTGCTAGAACA
  GACAGCCGTGGAGCTAGAGAAGAGGCAGGAGGGAAGAAGCAGCTCCCAGACGCTGGAGGGCAGCTGGACG
  TACGAGGAAGAGGCCAGCGAGAATGAGGCAGTCGCTGAGGAGGAAGAGGAGGGAGAGGAAGATGTCTTCA
  CTGAAAAGGTCTCTCCCGAGGCAGAGGAGTGCCCAGCATTAAAGGTGGACAGAGAGACCAATACTGACAG
  CGTGGCCCCATCCCCCACAGTGGTGCGCCCTAAGGACCGGAGGGTGGGTGCCCCGTCGACAGGGCCATTT
  CTTCGAGGGAATACCATCATCCGCTCCAAGACCTTCTCGCCTGGACCCCAGAGCCAGTATGTGTGTCGGC
  TAAACCGCAGTGACAGTGATAGTTCTACGCTGTCCAAGAAGCCACCTTTTGTGCGAAACTCCCTGGAGCG
  GCGCAGCGTCAGGATGAAGCGGCCTTCCTCCGTCAAGTCCCTGCGCACAGAGCGTCTGATCCGCACCTCG
  CTGGACCTAGAACTCGACCTGCAGGCCACGAGGACCTGGCACAGCCAGCTGACTCAGGAGATCTCAGTGC
  TGAAGGAGCTGAAGGAGCATTTGGAGCAAGCCAAGAACCACGGGGAGAAGGAGCTGCCACAGTGGCTGCG
  TGAAGACGAGCGCTTCCGCTTGCTACTGAGGATGCTGGAGAAGAAGGTGGATCGTGGGGAGCACAAGAGT
  GAGTTGCAAGCCGACAAGATGATGAGAGCTGCTGCCAAGGATGTGCACAGGCTTCGAGGCCAGAGCTGTA
  AGGAGCCCCCAGAAGTGCAGTCTTTCAGGGAGAAAATGGCATTTTTCACCCGGCCTCGGATGAACATCCC
  AGCTCTCTCTGCAGATGACGTCTAA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_170779
• Insert Size: 3315 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_170779.1, NP_740749.1
• RefSeq Size: 3315 bp
• RefSeq ORF: 3315 bp
• Locus ID: 211652
• UniProt ID: Q5SXA9
• Cytogenetics: 11 A4
• Gene Summary: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance (By similarity). Regulates collagen-stimulated activation of the ERK/MAPK cascade.[UniProtKB/Swiss-Prot Function]