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Usp36 (NM_001033528) Mouse Untagged Clone

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SKU
MC223559
Usp36 (untagged) - Mouse ubiquitin specific peptidase 36 (Usp36), (10ug)
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ORF Plasmid:
Tag Free tGFP DDK
  $1,052.00
6 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Usp36
Synonyms 2700002L06Rik; mKIAA1453
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>MC223559 representing NM_001033528
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGCCTATAGTCGATAAGCTGAAGGAGGCTCTCAAGCCTGGCCGCAAGGACTCGGCCGAGGATGGGGACC
TGGGCAGGCTGCTGGCAGCCTCTGCCAAGAAGGTGCTTCTGCAGAGGATTGAGTTTGAGCCGGCCAGCAA
GAGCTTCTCCTACCAGCTGGAGTCCTTGAAGAGCAAATACGTACTGTTGAGCGCCAGGGCTGAGGGAGCC
AGTCGCCACAGGAGCGGAGATGAACTCCAGGCCAGGAAACCAGGCACCGAGCGTGTGTCTGGAAGTGGAG
GCGACGGAGTCCCTGCCCCGCAGAAAGTGCTCTTCCCTGTGGAGCGTCTGTCCCTGAGGTGGGAACGTGT
TTTCCGAGTTGGCGCAGGGCTGCACAACCTGGGTAACACCTGCTTCCTCAACTCCACCATCCAGTGCTTG
ACCTACACACCACCTCTGGCCAACTACTTGCTCTCCAAGGAGCACGCACGGAGCTGTCACCAAGGGGGCT
TCTGCATGCTGTGTCTCATGCAAAACCACATGGTCCAGGCCTTTGCCAACAGCGGCAATGCTATCAAGCC
CGTCTCCTTCATCAGAGACCTGAAAAAGATTGCCCGGCACTTCCGGTTCGGGAACCAAGAGGATGCACAC
GAATTCCTGCGGTACACCATTGATGCGATGCAGAAGGCCTGCTTGAATGGCTACGCTAAGTTGGATCGGC
AGACACAGGCTACTACCCTGGTGCATCAGATCTTTGGAGGCTATCTCAGGTCCCGAGTGAAGTGCTCTGT
GTGCAAGAGTGTCTCAGACACATACGATCCCTACTTGGACATAGCACTGGAGATCCGGCAAGCTGCAAAT
ATTGTGCGCGCTCTGGAACTTTTTGTGAAGTCAGATGTCCTGAGTGGAGAGAACGCCTATATGTGTGCTA
AGTGTAAGAAGAAGGTTCCAGCCAGCAAGCGCTTCACCATCCATAGAACATCCAATGTCCTGACTCTGTC
CCTCAAGCGCTTCGCCAACTTTAGTGGGGGGAAGATCACCAAGGATGTTGGCTATCCAGAGTTCCTGAAC
ATCCGTCCATACATGTCGCAGAGCAGCGGTGATCCTGTCATGTATGGGCTCTATGCTGTCCTGGTGCACT
CAGGCTACAGCTGTCACGCTGGGCACTACTACTGCTATGTGAAGGCCAGCAATGGACAGTGGTACCAGAT
GAACGACTCCTTGGTCCATTCCAGCAATGTCAAGGTGGTTCTGAACCAGCAGGCCTACGTGCTCTTCTAT
CTGCGGATTCCAGGCTCTAAGAAAAGTCCTGAGGGCCCTGTCTCCAGAGTGGGCGCCACTCTCCCTAGCC
GTCCCAAAGTTGTTCCAGAGCACTCCAAGAAGAGCCCTGGCAATGGGGTTGTTCCCTCCCCGCTGATGGC
AAAGCGACAAGACTCTGTAATGATGAGAAAGCTCCCAGCCCCTGAGGAGGTTGGCGTACCTGTGTCCAGA
AATGGCTCCCTTCCTGGCCTGAAGTTACAGAACGGATGTGCTCCTGCCAAGACACCTGCCGGGTCCCCGT
CCCCAAGACTCACGCCCACGCCCACTCATATGCCCACCATTCTGGATGAGCCCGGAAAGAAGGTGAAGAA
GTCAGCCCCACTGCAGTCTCTCACCACATCTCCAACCACTTCTCAGGGCTCTCCTGGGACCGGCGAGTCC
CGGAGCCAGCGGCCCGGCTCCTGGGCAAGCAGAGACACCATCTTCTCTACCTCCCCGAAGCTCCTGGCCA
GAGCCATTACTAACGGGCACAGGCTGAAGGGCGAAGGCAGTGGTGTGGACCTGGAGAAGGGGGATTCAAG
CAGCTCCAGCCCCGAGCACTCTGCCAGCAGTGACCCTGCCAAGGCCCCGCAGACCGCAGAGAGCAGAGCT
GCGCATGCCTGTGATTCTCAGGGAACAAACTGTCCCACCGCTGGCCATCCCAAAGCGCTGTTGAATGGAG
TAGATGCCAAGATGGTGAAGTTGAAGTCCCCGGCCCTGAGCAGCACCACAACCGAGCCCACAAGCCTCAT
GTCTCCTCCACCAGCCAAAAAACTGGCCCTGTCAGCCAAGAAGGCCAGCACCCTGCGGAGGGCGACCGGC
AATGACATCGGTTCACCTTCCCCCTCAGCATTCTGCGACCTCACCTCCCCCATGAAAGCCACCCACCCCG
TCGTTGCCTCCACTGGGCCTGTCAGTAAGACCAGGACTGCTGCACCTGCCCCCCGACCGTCCACCCACCC
CCACTCTGCATCTCTGTCCAGTAGTAGTGCCAAGCCCTTAGGGACATCAGAGCCACAGAGCTGCCGCCCC
TCTGCCTGGACACCCCTGCCTCAGGTCAATGGACACTTCACGTCCCACTTACACCAACTGCCAGAGGCCA
GCGAGGCCCTACACAGCCCCTCCAAAAAGAGGAAAAAGACCCCTAATGGAGATCCCCAGAGACTGGGCAT
CGACACGCTCCTCCCACAGTGCCTCAGGGGAGCACCTGCAGCAGCACGCAGGAAGAGAAAGAAGAGGTGC
TCGGAGGGTGAGGGTGCCACAGCTCCCAAGCAGGAAGGCCAATTTCAGGACCAGTCTTGGAGTTCCGGGA
GCCAGAAGGAAGAGGGTACGCAGCCCCAGGTAAATGGCCATCAAGTGAGTCACATTCTGGACAGTTACCA
TGTGAGCAGCAGGAAAAGGAGGAAGAGGAAAAGATCGGAAGGACTCAGCCAGGAAGCCACCCCGTCGCAG
GACCTAATTCAGCACAGCTGCTCCCCTGTAGACCACAGTGAGCCTGAGGCCAGGACAGAGTTGCAGAAGA
AGAAGAAGAAGAAAAGAAGGAAAAGAAAGCCCGAGCCACAGCAGGATGAAGAGAGCAAGCACCCAGGAGA
CCAGAGGAGCCCAAGGCCCAGTGTCACCCCAGTCCCTGCGTTGAGTGTGAATGGCCATCTTCCTAGTGAC
TGCTTGGGGCTGGGACAAGCACCTCTCGTTACCTGGAACAGAGATCAGGAACCCGATGTGGTCCAGGCGT
TGCTTCAGGACTCATCTGATAAGGCTTATGGGAAAAAAGTTTTGACCTGGGATGGCGAGCCTTCAGCCAT
CAGTCAGGACGCCATCAAAGACAGCAGACTAGCCCGGACCCAGACCGTGGTTGACGACTGGGATGAAGAG
TTTGATCGAGGGAAGGAAAAGAAAATTAAAAAGTTCAAGAGAGAAAAGAAGAGAAACTTCAATGCCTTCC
AGAAGCTTCAGAGTAGGCGCAACTTTTGGTCTGTGACGCATCCTGCTAAGGTGGCCAGCCTCAGCTATCG
CCGCTGA

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI |
ACCN NM_001033528
Insert Size 3297 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001033528.1, NP_001028700.1
RefSeq Size 5609 bp
RefSeq ORF 3297 bp
Locus ID 72344
UniProt ID B1AQJ2
Cytogenetics 11 E2
Summary Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634). Function as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm. Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions. Deubiquitinates SOD2, regulates SOD2 protein stability. Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_001033528" in other vectors (4)
SKU Description Size Price
MG226452 Usp36 (tGFP-tagged) - Mouse ubiquitin specific peptidase 36 (Usp36), (10ug) 10 ug
$1,156.00
MR226452 Usp36 (Myc-DDK-tagged) - Mouse ubiquitin specific peptidase 36 (Usp36) 10 ug
$589.00 $956.00
MR226452L3 Lenti ORF clone of Usp36 (Myc-DDK-tagged) - Mouse ubiquitin specific peptidase 36 (Usp36) 10 ug
$1,256.00
MR226452L4 Lenti ORF clone of Usp36 (mGFP-tagged) - Mouse ubiquitin specific peptidase 36 (Usp36) 10 ug
$1,256.00

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