Ptprh (NM_207270) Mouse Untagged Clone

CAT#: MC222937

Ptprh (untagged) - Mouse protein tyrosine phosphatase, receptor type, H (Ptprh), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Ptprh
• Synonyms: R-PTP-H; sap-1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC222937 representing NM_207270
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCCAGAGCTGGTGGGAACTGTGGGGTTTGGAGGAGCTTGGTGCTATTGGGTTTGTATGGTTGTTCTG
  TGGTCAGGGCAGCTGGTACCAGTGTCACAGTGGACAGGCATGCTCCTGCTTCTTCATACGAGTTTTCCAT
  GTGGGTAGAGAAAGATGGCGTCAGCAGCTCCCCACAGATTCCTGTAACCACCGCAGCCCCAAACCCAGTG
  AGAAACCTGAGGGTCGAAGGTCAAAACAACATCTCCATCAGCCTGAGCTGGGAGCCTCCTGATCAGTCCT
  CCCTGCAGGGCCTCACCTACTGGACCCAGTGCAGTAGACATGGTGGCCAAACTGAGACCCGGAACACAAC
  AGACACCAGTGTCACCGTGGATGGCCTTGATCCTGGGTCTTCATATGAATGTTCTGTGTGGGTGGAAAAG
  GATGGACTCTATAGCAAAAATGAGACTCTCAATACCAGCACAGCTCCAAACCCAGTGAGAAACCTGAGGG
  TCGAAGGTCAAAACAACATCTCCATCAGCCTGAGCTGGGAGCCTCCTGATCAGCCCTCCCTGCAGGGCCT
  CACCTACTGGGCCCAGTGCAGTAGACATGGTGGCCAAACTGAGACCCGGAACACAGCAGACACCAGTGTC
  ACCGTGGATGGACTTGATCCTGGGTCTTCATATGAATGTTCTGTGTGGGTGGAAAAGGATGGAGTCTATA
  GCACCAATGAGACTCTCAATACCAGCACAGCCCCAAACCCAGTGAGAAACCTGAGGGTCGAAGGTCAAAA
  CAACATCTCCATCAGCCTGAGCTGGGAGCCTCCTGATCAGCCCTCCCTGCAGGGCCTCACCTACTGGGCC
  CAGTGCAGTAGACATGGTGGCCAAACTGAGACCCGGAACACAACAGACACCAGTATTACCGTGGATGGAC
  TTGATCCTGGGTCTTCATATGAATGTTCTGTGTGGGTGGAAAAGGATGGAGTCTATAGCACCAATGAGAC
  TCTCAGTAACACCACAGCCCCAAACCCAGTGAGAAACCTGAGGGTCAAAAGTCAGAACAACTTCTCCATC
  AGCCTGAGCTGGGAGCCTCCTGATCAGCCCTCCCTGCAGGGCCTCATCTACTGGGCCCAGTGCAGTAGAC
  ATGGTGGCCAAACTGAGACCCGGAACACAACAGACACCAGTGTCACCGTGGATGGACTTGATCCTGGGTT
  TTTATATAAATGTTCTGTGTGGGTGGAAAAGGATGGAGTCTATAGCACCAATGAGACTCTCAATACCAGC
  ACAGTCCCCATTTCAGCCTCAAACCCAGTGAGAAACCTGAGGGTCGAAGGTCAGAACAACTTCTCCATCA
  GCCTGAGCTGGGAGCCTCCTGATCAGTCCTCCCTGCAGGGCCTCACCTACTGGGCCCAGTGCAGTAGACA
  TGGTGGCCAAACTGAGACCCGGAACACAGCAGACACCAGTGTCACCGTGGATGGCCTTGATCCTGGGTCT
  TCATATGAATGTTCTGTGTGGGTGGAAAAGGATGGAGTCTATAGCACCAATGAGACTCTCAATACCAGCA
  CAGTACCAGCTGCTGTCAACATCACCTCCTGCATCAGCACTTCTGGGGGATATGGGGTCCTCCTGACCTG
  GTCCTGCCCATCTGGGGGTTATGAGAGCTTTGAGGTAAAAGTGGGTAGGAAATGGCGCTCTGAAAATGGA
  TCTTTGTGTGGGAAGGGCGTGACCGTGTCAGATCTTGAGCCAGCTCAGTCCTACACAGCCACCGTCACGA
  CTGTCTTCAAGGACCTGAAGGCCCAGTCTCTCTCTACAACTTGCCACACAGAGAGTGCAGCCATCATTGC
  TGGAGCCATTGTGGGCATCCTCCTGCTTTTCATCCTGGTGGGTCTGCTGATTGTCTTCCTGAAGAGGAGG
  AGAAAGAAGAGACAGCCCAAGGAAGTGCCCAAGGATCTGGTGTGCAGCTGCCCAGGGGATATCCTGGCCA
  AAGACTTTGCTGACCATGTCAGGGAGAATGAGAAGGACAGCAACTGTGGATTTGCTGAGGAGTATCAGCA
  ACTGGCTCTGGAGGGCCAAGGCCAGTCTCAAATAACGGCATCGGCTCTAGAGAACAGATCCAAGAACCGC
  TACAGGAATGTACTGCCCTATGACTGGTCCCGGGTTCCCCTGCAGCCCCTCCAAGAGGAACCAGGCTCTG
  ACTATATCAACGCCAGCTTTATGCCTGGTCTCTGGAGCCCCAAGGAGTTCATTGCAACCCAGGGTCCCCT
  GCCTAACACTGTGGGTGATTTTTGGAGAATGGTCTGGGAACAGCAGAGCCACACCCTGGTTATGCTGACC
  AACTGCATGGAGTCTGGACGGGTGAAGTGTGAGCACTACTGGCCCTTGGATGCTCAGCCTTGCATTCATG
  GGCAGCTGCAGGTAATGTTGATTAGTGAGGAGGCGTCAGAAAACTGGACAGTGAGGCATCTTCAACTCTT
  CCATATGAAAGAACAGCAGACTCTCTCGTTGCGCCAATTCCACTACCTGGCCTGGCCAGACCATGGAGTT
  CCTTACTCCCCAGACCCCCTGCTGGCTTTCCGAAAGATGCTTCGGCAATGGATGGATCAGACCACGGATG
  GAGGTCCACCCATTGTGCATTGCAGTGCTGGTGTGGGCCGGACGGGCACCCTAATTGCACTGGATGTCCT
  GCTGCGGCAGCTGGAGTGTGAGGGGCTGGTGGGTCCCTTCAGCTTTGTGAAGAAGATGAGAGAGAGCCGG
  CCACTGATGGTGCAGACAGAGGCCCAGTATGTGTTCCTCCACCAGTGCATCTTGAAATCCCTCCAGAAGC
  CAGCTCCAGCCCTTGTCCCAGAGGAGGCAATGTATGAGAACGTGGCAAGCTTAGTTTATGAGAATGCATC
  TGCTATCATGGCCCATGAGTCTGAGTTCTCAGCTTCTGGGTGCTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_207270
• Insert Size: 2916 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_207270.2, NP_997153.2
• RefSeq Size: 4020 bp
• RefSeq ORF: 2916 bp
• Locus ID: 545902
• UniProt ID: E9Q0N2
• Cytogenetics: 7 A1
• Gene Summary: Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of Jurkat cells (By similarity). Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response (PubMed:26195794).[UniProtKB/Swiss-Prot Function]