Il17ra (NM_008359) Mouse Untagged Clone

CAT#: MC222257

Il17ra (untagged) - Mouse interleukin 17 receptor A (Il17ra), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Il17ra
• Synonyms: AW538159; Cdw217; Il17r; VDw217
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC222257 representing NM_008359
  Red=Cloning site Blue=ORF
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCGATTCGGCGCTGCTGGCCACGGGTCGTCCCCGGGCCCGCGCTGGGATGGCTGCTTCTGCTGCTGA
  ACGTTCTGGCCCCGGGCCGCGCCTCCCCGCGCCTCCTCGACTTCCCGGCTCCGGTCTGCGCGCAGGAGGG
  GCTGAGCTGCAGAGTCAAGAATAGTACTTGTCTGGATGACAGCTGGATCCACCCCAAAAACCTGACCCCG
  TCTTCCCCAAAAAACATCTATATCAATCTTAGTGTTTCCTCTACCCAGCACGGAGAATTAGTCCCTGTGT
  TGCATGTTGAGTGGACCCTGCAGACAGATGCCAGCATCCTGTACCTCGAGGGTGCAGAGCTGTCCGTCCT
  GCAGCTGAACACCAATGAGCGGCTGTGTGTCAAGTTCCAGTTTCTGTCCATGCTGCAGCATCACCGTAAG
  CGGTGGCGGTTTTCCTTCAGCCACTTTGTGGTAGATCCTGGCCAGGAGTATGAAGTGACTGTTCACCACC
  TGCCGAAGCCCATCCCTGATGGGGACCCAAACCACAAATCCAAGATCATCTTTGTGCCTGACTGTGAGGA
  CAGCAAGATGAAGATGACTACCTCATGCGTGAGCTCAGGCAGCCTTTGGGATCCCAACATCACTGTGGAG
  ACCTTGGACACACAGCATCTGCGAGTGGACTTCACCCTGTGGAATGAATCCACCCCCTACCAGGTCCTGC
  TGGAAAGTTTCTCCGACTCAGAGAACCACAGCTGCTTTGATGTCGTTAAACAAATATTTGCGCCCAGGCA
  AGAAGAATTCCATCAGCGAGCTAATGTCACATTCACTCTAAGCAAGTTTCACTGGTGCTGCCATCACCAC
  GTGCAGGTCCAGCCCTTCTTCAGCAGCTGCCTAAATGACTGTTTGAGACACGCTGTGACTGTGCCCTGCC
  CAGTAATCTCAAATACCACAGTTCCCAAGCCAGTTGCAGACTACATTCCCCTGTGGGTGTATGGCCTCAT
  CACACTCATCGCCATTCTGCTGGTGGGATCTGTCATCGTGCTGATCATCTGTATGACCTGGAGGCTTTCT
  GGCGCCGATCAAGAGAAACATGGTGATGACTCCAAAATCAATGGCATCTTGCCCGTAGCAGACCTGACTC
  CCCCACCCCTGAGGCCCAGGAAGGTCTGGATCGTCTACTCGGCCGACCACCCCCTCTATGTGGAGGTGGT
  CCTAAAGTTCGCCCAGTTCCTGATCACTGCCTGTGGCACTGAAGTAGCCCTTGACCTCCTGGAAGAGCAG
  GTTATCTCTGAGGTGGGGGTCATGACCTGGGTGAGCCGACAGAAGCAGGAGATGGTGGAGAGCAACTCCA
  AAATCATCATCCTGTGTTCCCGAGGCACCCAAGCAAAGTGGAAAGCTATCTTGGGTTGGGCTGAGCCTGC
  TGTCCAGCTACGGTGTGACCACTGGAAGCCTGCTGGGGACCTTTTCACTGCAGCCATGAACATGATCCTG
  CCAGACTTCAAGAGGCCAGCCTGCTTCGGCACCTACGTTGTTTGCTACTTCAGTGGCATCTGTAGTGAGA
  GGGATGTCCCCGACCTCTTCAACATCACCTCCAGGTACCCACTCATGGACAGATTTGAGGAGGTTTACTT
  CCGGATCCAGGACCTGGAGATGTTTGAACCCGGCCGGATGCACCATGTCAGAGAGCTCACAGGGGACAAT
  TACCTGCAGAGCCCTAGTGGCCGGCAGCTCAAGGAGGCTGTGCTTAGGTTCCAGGAGTGGCAAACCCAGT
  GCCCCGACTGGTTCGAGCGTGAGAACCTCTGCTTAGCTGATGGCCAAGATCTTCCCTCCCTGGATGAAGA
  AGTGTTTGAAGACCCACTGCTGCCACCAGGGGGAGGAATTGTCAAACAGCAGCCCCTGGTGCGGGAACTC
  CCATCTGACGGCTGCCTTGTGGTAGATGTCTGTGTCAGTGAGGAAGAAAGTAGAATGGCAAAGCTGGACC
  CTCAGCTATGGCCACAGAGAGAGCTAGTGGCTCACACCCTCCAAAGCATGGTGCTGCCAGCAGAGCAGGT
  CCCTGCAGCTCATGTGGTGGAGCCTCTCCATCTCCCAGACGGCAGTGGAGCAGCTGCCCAGCTGCCCATG
  ACAGAGGACAGCGAGGCTTGCCCGCTGCTGGGGGTCCAGAGGAACAGCATCCTTTGCCTCCCCGTGGACT
  CAGATGACTTGCCACTCTGTAGCACCCCAATGATGTCACCTGACCACCTCCAAGGCGATGCAAGAGAGCA
  GCTAGAAAGCCTAATGCTCTCGGTGCTGCAGCAGAGCCTGAGTGGACAGCCCCTGGAGAGCTGGCCGAGG
  CCAGAGGTGGTCCTCGAGGGCTGCACACCCTCTGAGGAGGAGCAGCGGCAGTCGGTGCAGTCGGACCAGG
  GCTACATCTCCAGGAGCTCCCCGCAGCCCCCCGAGTGGCTCACGGAGGAGGAAGAGCTAGAACTGGGTGA
  GCCCGTTGAGTCTCTCTCTCCTGAGGAACTACGGAGCCTGAGGAAGCTCCAGAGGCAGCTTTTCTTCTGG
  GAGCTCGAGAAGAACCCTGGCTGGAACAGCTTGGAGCCACGGAGACCCACCCCAGAAGAGCAGAATCCCT
  CCTAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_008359
• Insert Size: 2595 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_008359.2, NP_032385.1
• RefSeq Size: 3970 bp
• RefSeq ORF: 2595 bp
• Locus ID: 16172
• UniProt ID: Q60943
• Cytogenetics: 6 56.95 cM
• Gene Summary: Receptor for IL17A (PubMed:17911633, PubMed:20554964, PubMed:8777726). Receptor for IL17F (PubMed:17911633, PubMed:20554964). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848, PubMed:21993849, PubMed:21982598). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (By similarity).[UniProtKB/Swiss-Prot Function]