Neurl1a (NM_021360) Mouse Untagged Clone

CAT#: MC219170

Neurl1a (untagged) - Mouse neuralized homolog 1A (Drosophila) (Neurl1a), transcript variant 1, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Neurl1a
• Synonyms: 2410129E16Rik; AI450910; AI481072; Neu1; Neur1; Neurl; Neurl1; Nlz; Rnf67
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC219170 representing NM_021360
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGGTAACAACTTCTCCAGTGTCTCCTCTCTGCAGCGAGGAAACCCGAGCCGCGCGTCGCGGGGCCACC
  CCCAGAACCTCAAAGACTCCATCGGGGGCTCCTTCCCGGTGCCCTCTCACCGATGCCATCACAAGCAGAA
  GCATTGCCCGCCTACGCTGTCAGGTGGGGGGCTCCCGGCCACGCCGCTGCTCTTCCATCCCCACACTAAG
  GGCTCCCAGATCCTCATGGACCTCAGCCACAAGGCCGTCAAGAGGCAGGCCAGCTTTTGCAATGCCATCA
  CCTTCAGTAACCGCCCGGTGCTCATCTACGAGCAAGTCAGGCTGAAGATCACCAAGAAGCAATGCTGCTG
  GAGCGGGGCCCTGCGACTTGGCTTCACCAGCAAGGACCCTTCCCGCATCCACCCCGACTCGCTGCCCAAG
  TACGCCTGCCCTGACCTGGTGTCTCAGAGTGGCTTCTGGGCCAAAGCATTGCCTGAGGAGTTTGCCAACG
  AGGGCAACATCATTGCCTTCTGGGTGGACAAGAAGGGCCGCGTCTTCTACCGGATCAATGAGTCAGCTGC
  TATGCTTTTCTTCAGTGGGGTCCGGACGGTGGACCCGCTCTGGGCCCTGGTGGACGTCTACGGCCTCACG
  CGGGGTGTCCAGCTGCTAGACAGCGAGCTGGTGCTGCCCGACTGCCTGCGGCCGCGCTCCTTCACCGCGC
  TGCGGCGGCCGTCGCTGCGGTGCGAGGCGGATGAGGCGCGCCTGTCGGTGAGCCTGTGCGACCTCAACGT
  GCCGGGAGCCGACGGCGACGACGGCGCACCGCCTGCCGGCTGCCCGATCCCGCAGAACTCGCTCAATTCT
  CAGCACAGCCGCGCGCTGCCGGCGCAGCTCGACGGCGACCTGCGCTTCCACGCGCTTCGCGCCGGCGCGC
  ACGTCCGCATCCTGGACGAGCAGACGGTGGCGCGCCTGGAGCACGGGCGCGACGAGCGCGCGCTCGTCTT
  CACCAGCCGGCCTGTGCGCGTGGCCGAGACCATCTTCATCAAGGTCACGCGCTCGGGCGGGGGGCGAGCG
  GGCGCGCTGTCCTTCGGGGTCACCACGTGTGACCCTGGCACGCTGCGGCCCGCCGACCTGCCCTTCAGCC
  CCGAGGCCCTGGTGGACCGCAAGGAGTTCTGGGCGGTGTGTCGCGTGCCCGGGCCTCTGCACAGCGGCGA
  CATCCTGGGCCTGGTGGTCAACGCGGACGGAGAGCTGCACCTGAGTCACAACGGCGCGGCGGCCGGCATG
  CAGCTGTGCGTGGATGCCTCGCAGCCCCTCTGGATGCTCTTCAGCCTGCATGGCGCCATCACGCAGGTCC
  GCATCCTCGGCTCCACCATCATGACTGAACGGGGTGGCCCATCTCTCCCCTGCTCACCTGCCTCCACTCC
  AACCTCACCCAGTGCCCTGGGCATCCGCCTCTCTGACCCCCTGCTCAGCACCTGCGGTTCTGGGCCCCTA
  GGTGGCTCTGCTGGAGGGACAGCCCCCAACTCACCTGTGAGCCTGCCCGAGTCACCGGTGACCCCAGGTC
  TGGGCCAGTGGAGTGATGAATGCACCATTTGCTATGAACACGCAGTGGACACAGTCATCTACACGTGTGG
  CCACATGTGCCTGTGCTACTCCTGTGGCCTGCGCCTCAAGAAGGCCCTGCACGCCTGCTGCCCCATCTGC
  CGTCGCCCCATCAAGGACATCATCAAGACCTACCGCAGCTCCTAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_021360
• Insert Size: 1725 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_021360.4, NP_067335.4
• RefSeq Size: 4168 bp
• RefSeq ORF: 1725 bp
• Locus ID: 18011
• UniProt ID: Q923S6
• Cytogenetics: 19 39.39 cM
• Gene Summary: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).