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Fbxw11 (BC034261) Mouse Untagged Clone

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SKU
MC206754
Fbxw11 (untagged) - Mouse F-box and WD-40 domain protein 11 (cDNA clone MGC:28671 IMAGE:4237375), (10ug)
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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Fbxw11
Synonyms HOS, mKIAA0696, BTRC2, BTRCP2
Vector PCMV6-Kan/Neo
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>BC034261
GGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAAGACAAGACCATCGAGCTCATGTGTTCTGTG CCAAGGTCTTTGTGGCTAGGCTGCGCCAACCTGGTAGAGAGCATGTGCGCACTGAGTTGCCTGCAGAGCA TGCCCAGTGTCAGATGTCTCCAGAACACTTCAGTTATGGAAGATCAAAATGAAGATGAGTCCCCAAAGAA AAGTGCTCTTTGGCAGATCAGTAATGGAACGTCATCTGTGATTGTCTCCAGAAAGAGGCCGTCAGAGGGG AACTACCAGAAAGAAAAGGACTTGTGCATTAAGTACTTTGACCAGTGGTCTGAATCAGATCAGGTGGAAT TTGTGGAGCATCTTATCTCACGGATGTGTCATTATCAGCATGGACATATTAACTCTTACCTGAAGCCCAT GTTGCAGCGGGACTTTATCACTGCTTTACCAGAGCAAGGCTTAGATCACATAGCAGAAAACATTCTCTCC TACCTGGATGCCAGGTCTCTGTGTGCAGCAGAGCTGGTGTGTAAAGAATGGCAGCGAGTGATCTCAGAAG GGATGCTTTGGAAGAAGCTGATTGAGAGGATGGTGCGCACCGACCCTCTCTGGAAGGGACTCTCAGAAAG AAGAGGCTGGGATCAGTACCTGTTTAAAAACAGACCTACAGATGGCCCTCCCAACTCATTTTATAGATCA TTATACCCAAAGATTATCCAGGACATAGAGACCATAGAATCCAACTGGCGGTGTGGACGACACAACTTGC AGAGGATCCAGTGCCGCTCTGAAAATAGTAAGGGTGTCTACTGTTTGCAATATGATGATGACAAAATTAT CAGTGGCCTCCGGGACAACTCTATCAAGATCTGGGATAAAAGCAGCTTGGAATGTTTGAAAGTGCTAACG GGCCACACAGGCTCTGTCCTCTGCCTCCAGTATGATGAGCGAGTCATTGTAACTGGTTCTTCAGACTCCA CGGTGAGAGTCTGGGATGTGAACACTGGTGAGGTGCTCAACACACTCATCCACCACAATGAAGCCGTACT GCACTTACGCTTCAGCAATGGACTGATGGTGACTTGTTCCAAGGACCGTTCCATTGCCGTGTGGGACATG GCTTCTGCCACCGATATCACTTTACGCCGTGTTCTGGTTGGCCACCGTGCTGCTGTCAATGTAGTAGACT TTGATGATAAATACATCGTGTCTGCTTCAGGAGACAGGACCATTAAAGTGTGGAGCACGAGCACATGTGA GTTTGTCCGCACTCTGAATGGGCACAAGCGAGGCATCGCCTGTCTGCAGTACCGCGACCGGCTTGTTGTT AGTGGATCATCAGATAATACCATCCGGTTATGGGATATTGAATGTGGTGCCTGTTTAAGAGTCCTAGAGG GGCACGAAGAATTGGTCCGGTGCATCCGTTTTGATAACAAGAGGATTGTCAGTGGCGCCTATGATGGGAA GATTAAAGTCTGGGACTTGCAGGCTGCTCTTGACCCTCGGGCCCCAGCAAGCACATTGTGTCTGCGCACC TTGGTGGAACACTCTGGACGTGTGTTTCGGCTGCAGTTTGATGAGTTTCAGATCATCAGCAGCTCCCATG ATGACACTATTTTGATTTGGGATTTCTTAAATGTGCCTCCCAGTGCCCAGAATGAGACCCGCTCTCCCTC CAGAACCTACACCTATATCTCCAGATAGCAGCCTGCACTTTGGCCCAATCTGGGTTTCCTGGTCTTGAAC TACTGGCTATATGGCTATCACATGCCTAAGGGAGTTCGTTCACAGCTGAGTTTGGGGCTGGACTGGTTCC AGATGCTGGGTAGATACAGAGCAGCCCCACCCCTCAAGCCCTGACATTCTCACTGCACCCCAGCTCTACT TGGAGAAGGACTCCTTAGCTCTCCACTGCAAGTAGAGCAGCAGCTCATGTCCCTCCCTTCAGTGAAGACC CCAGCGCTTCCCATGCACACGTTCCCACGAAGGACACAGCAAGGACTGTCAGGAGAAGCCCTGCTTCTAA CTTATGTCGTCGCTTTGCGCCTTGGTTTGGTACTAAAAGCAGCCTTGCATTCTCGGTGAAGTGCTGGGTG CCAAACGACTACACAGCGTCTTCAGGGCTTTCCTCTCCAGCAGCAGCTTCTCCTTAGACCGTCAGTCACA GTCACCGTCGCTCTGACGTGCATAGGAATGTGTCGGACAATGGGCAGATCTGGATTATCTTAGTATTTTT GGATTACACTTTCTTTCTGTTTGTTTCTTTTAATTTAAAGAATAAGTGGGCTATATTACCTCTGCACAGG TGATATAGCTATTTTCTTTTATTAACTGTTCTCTGTTCTTCCTCATCTTCTGATATTTGGTAGAGTAACA CCTTTATCCGAGTGCTTGCCTCCTAATTTAAAATACTGTATCCGCATGTAGATAGAGTGTACATAACAGT CCAAGCTCAAGGGTGCTGGCCGGCCCCCTGCACCTGAGACACTACTGTGGAGATTGTCACACCTACTCCA GGGTTGCTGTGCTGGCCTAGAGCCTCCTTCAGTATTCACTTGGGTTTTAGTTGTCACTGTCTTTGTGTGT GCTGTGTGTTTTCAGACAGAACTTGAGAAGTCTCCCATGTTTATTTGTTGTGTGACATCTGCAGTGGGCA GGTATCTTCACAGTCTCCACATTGCTGTTCTTTTCCTCACGCTTACCCCTAGAGCTAGTGCTCACCTCCT TGGGGTGATCATTAGCTTCTCTGTCCAACATCCTACCACACGGCAGTGACCCTGAGATGGAGATGGCGGC CAGTGGACAGGGCTCCTGGCTCTGGGCTCCCTGTACTCGGATGGGTGTTGGGGGCTATAGAGTTAGAGCC TGTGGAGCAGGTCAGCTGGCCAGAGCCCTCATTAGGGACAAGGCACTCCTCTGTGTGTGGGGCACAGCCT CAGGCCCTGTCAGCTCTGCTGTCACTCATCACGGTGAGAGTGGCACCCAGGCAGGACATTGGTGACATTA TTTCCCTCTTTCAAAATTAGGTTTTGATTTCCCCTTGCCATTGTTTCCAAAGATGAAGGAATGTTAGTAC GGTTTTAAAGGACCAACCAGCCCCTCCCAGTGAATGAAGCCTCTTCCCATGGAAGCACACTCTAGGAGAG AGAAGGCCTCTGGGCTCCGCCTGGCCTGGCATTATGAATGCAGTGGGGTCAGTGTGTGGTGGATGTGTGT ACTGGGTTGGCTTTCCTTTTTAGTTTTTTTACTTTTTAGTTTAGTTTGTTCTTTTCCTTCCCCAATAAAT CATTCTCACATGCTTCCATGTTTGTTTCTGAGAGGTGGGGGCTCAAATGTATAGAAAGTAGGCCCCAGTC CATAAGGAGGTGTGAACACACCCCCTTACTGCTTATCACCCATTTGACAGGAACGCCCAGGAGGAGAGGG GGAGGGGAAGAGGTGAGTTCTGCACAGTCGGACATTTCTGTTGCTTTTGCATGTTTAATATAGACGTTCC TGTCGATCCTTGGGAGATCATGGCCTTCAGATATGCACACGACCTTTGAATTGTGCCTACTAATTATAGC AGGGGACTTGGGTACCCAAGGAATTCCAATTTCTGGGATTACAGTAGTAATTCCCAGCTGTACTCTGGAC TTGATTTTGCTAACTGTAACTGAGCAACTGTAAATTACTGCTATATTAATGTGTTAAAGCACTGGGGTAG TCTAATTCTAACTGGTAATTATGTTTGCCAATTATCTGTTTGAAATAAATATGTGTCTGAACAGCTATTG AAACTGTTAAATTGTACAGATATTATCATGACGGCTTTGTACTGTGGAATGTGCTTAATAAAAACAAAAG TTTGACCTTTGTCCAATAAATTGCTAAGTAATGTCAATAAATCAAGATGAGTATTATGCAGTACACCTGA CCTGGCTTCCTGGCGATTGTTACTTCAGCTACTGATTCAAGCCAATCCTCTAAATAAAGTGTTGCAGTGC TCCTCTGTTCTGTCACATTTCTCAGAAAAAAAAAAAAAAA
Restriction Sites RsrII-NotI |
ACCN BC034261
Insert Size 1692 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq BC034261, AAH34261
RefSeq Size 4030 bp
RefSeq ORF 1692 bp
Locus ID 103583
Cytogenetics 11 A4
Summary Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (By similarity).UniProtKB/Swiss-Prot Function
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