Jub (BC011035) Mouse Untagged Clone

CAT#: MC206273

Jub (untagged) - Mouse ajuba (cDNA clone MGC:13721 IMAGE:4187633), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Jub
• Synonyms: Jub
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC011035
  CCACGCGTCCGGCGCCCGGCACCTGGGCCGCTCGCTGAGCCCCCGTGAGTGACTTGCATCCCAGGAATCC GAGCCCCGGGGAACTCGAGCCCGGCCTCTGGCCGAAACACTGCAGCGTGCCGGGCGAGGAGGGGGCTGCA GGCCCCAGATCCGTGGGCATGGAACGGTTAGGGGAGAAAGCCAGTCGTCTGCTAGAAAAGTTGAGACTCT CGGACTCCGGCAGCGCCAAGTTCGGCCGCAGAAAGGGCGAAGCGAGCCGATCTGGGTCTGATGGGACCCC CGGAGCAGGCAAGGGACGCTTAAGCGGGTTGGGGGGACCTAGGAAGTCAGGACACCGTGGAGCGAATGGT GGGCCTGGAGATGAACCTTTGGAACCGGCCAGGGAGCAAGGGCCCCTGGACGCCGAGCGGAACGCACGCG GCTCCTTTGAAGCGCAGCGCTTCGAAGGGTCCTTTCCCGGGGGGCCGCCGCCCACTCGAGCCCTGCCTCT GCCTCTGTCGTCGCCTCCTGATTTTCGGCTGGAGACCACGGCTCCAGCCCTTAGCCCTCGCTCCAGCTTC GCCAGTAGCTCGGCCAGCGATGCGAGCAAGCCATCTAGCCCCCGGGGCAGCCTGCTGCTGGACGGAGCGG GGGCCAGCGGAGCCGGAGGTAGCCGGCCGTGCAGCAATCGGACCAGCGGCATCAGCATGGGCTACGACCA GCGCCACGGGAGCCCGCTGCCCGCGGGGCCGTGCCTATTCGGCCTCCCGCTGACCACTGCTCCTGCGGGC TACCCAGGAGGGGCTCCGTCCGCCTACCCGGAGCTCCACGCTGCCCTGGACCGACTATGTGCTCATCGGT CCGTGGGATTCGGCTGCCAGGAGAGCCGTCACTCGTACCCCCCGGCCCTGGGCAGCCCCGGAGCTCTAAC CGGAGCCGTGGTGGGAACAGCGGGTCCTTTGGAGAGACGTGGGGCGCAACCCGGACGACACTCGGTTACA GGCTACGGGGACTGCGCCGCGGGGGCCCGTTACCAGGACGAGCTAACAGCATTGCTGCGTTTGACCGTGG CTACCGGTGGGCGAGAAGCCGGTGCTCGCGGGGAACCCTCGGGGATTGAGCCGTCGGGTCTGGAGGAGTC TCCTGGTCCCTTCGTTCCAGAGGCCTCCCGATCACGGATACGGGAGCCAGAGGCCAGAGAAGATTACTTT GGCACCTGTATCAAGTGCAACAAAGGTATCTATGGGCAGAGCAATGCCTGCCAGGCCCTGGACAGCCTCT ACCACACCCAGTGCTTTGTCTGCTGCTCCTGTGGACGAACTTTGCGGTGCAAGGCTTTCTACAGCGTCAA TGGCTCTGTCTACTGTGAGGAAGACTATCTGTTTTCAGGGTTTCAGGAGGCAGCTGAGAAGTGCTGTGTC TGTGGCCACTTGATTCTAGAGAAGATCCTCCAGGCCATGGGGAAGTCCTATCACCCGGGCTGCTTCCGAT GCATCGTATGTAACAAGTGCCTGGACGGCGTCCCCTTCACTGTGGACTTCTCCAACCAGGTGTACTGTGT TACCGACTACCACAAAAATTACGCCCCGAAATGTGCAGCCTGCGGACAACCCATCCTCCCCTCAGAGGGC TGTGAGGACATTGTGAGGGTGATATCCATGGACCGTGATTATCACTTTGAGTGCTACCACTGTGAGGACT GCCGCATGCAGCTGAGTGACGAGGAAGGTTGCTGCTGTTTCCCTCTTGATGGACATTTGCTCTGCCACGG CTGTCACATGCAGCGCCTCAGTGCCCGGCAGCCCTCTACCAACTATATCTGAGCTGACGTTACTGCTGCC GCCACCACTGTGGAGAAACTCTCTGGCCAGCGGAGGCAAGGAGTGTATTCTGCAATCCTTGTGAAGAGGT CTCTGGGGAGGCCCCGAAGGCCAGAGACCCAAAGATCCTAACATTCCAAATGGGCTGCGGAGGAGGAACC TTCTGGTTGCCGGGAGAGTTGACTGGTGTTCATTGCGTGCAGCCTGTGCTACAGTAGATGGGATGTAGCA CACGCAGGCGGGTTTCAGTACTTCCTGAACGCCAGATTATAATGTATTTTTCCAGTGTATGTTTCTATAT ACGTCACACAATGTTCTGGTGCTGGATCACATGAGGGCATCACAGAAACCAACCCCAGTCTGTTGTACCC TATGCATGGAGTCAGTGGAACCTTTCCCACGGGATCCTATCTTTGTCTGCGCTAAGGGCTGGAAGCCCTG GACTTCATGATGAGCCATTTCTTGGCTCTCTCCCTAAGGACTAGAGAGCTCCCCGTGTCTGTCTGCTGGG ACTGGGACCAGCTCTGGGGGACCTTGCTGCCTGTGTTGCCTGTTTCTCAGGGACCTGGGGAGGCTAACTG GGGCCTGTCCCTGGTTGCTGTTTTGCTCTTCTGGGGGAAGAAATGAGCAGGTTTCTGGATGTGAAACTTG CCGGTGAGTAGGATGTCCCTGAAGCATCAGGCTAGCCCCACTCCCCCTGTTTAAGTGCACTGAGCCTGTA GCCTAGCATATGTGGATACATTGTAGCCACGTGTGCCTGTGCACCTCCCTCCCTACTCCTCTTTTCTCAG GTGACTTACGCTTAGTTCCCTAGCAGTAGCCTATCTTTTGAGACCCATTTTTAAAAGGGATCCTGCATTG GATCTGACCTGTTACAACCCCACCACTCAAGGCATTGGGGAAGCTGGAGAGAAGAAAAATAGGTTGACTT GGTTCTAGCCGCTTGGCTGAAACTTGAATTCACCTTAAGCAGGATGTCTTAAAGCCAGGTCACTTGCTGG CTGGAACTTAAATTCATTTGATGACCAGCTTGCCAAGAGTCCTGTCCCCTACTGATGTGTTCTTATAGCT GCCTACATGTTTTGTTCTTTTCATTGCACTGAGCATTCAGTGATTCCTGCCTGTTCATCAAGAGTATGTC AGAGGTTTGTTTGTTTTTTGGTTTTTCGAGACAGGGTTTCTCTGTATAGCTCTGGCTGTCCTGGAACTCA CTCTGTAGACCAGGCTGGCCTTGAACTCAGAAATCCACCTGCCTCTGCCTCCCGAGTGCTGGGATCAAAG GCGTGCGCCACCACGCCTGGCTTACTTCAGAGTTATTAGCATCTTACATTTATCAACTTTGTGGCACTTT GTGATACAAATGTTCCCTGCCTCCTTGGGTGTCTTCCTACTATGCCATTATTTCTCTGACACTTAAGAAA GAAAAAGTTGAAATTCTAGCAGTAAATACAGTTGATGCAGACAAAAAAAAAAAAAAAAAA
• Restriction Sites: EcoRI-NotI
• ACCN: BC011035
• Insert Size: 1644 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC011035, AAH11035
• RefSeq Size: 3280 bp
• RefSeq ORF: 1644 bp
• Locus ID: 16475
• Cytogenetics: 14 C2
• Gene Summary: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.[UniProtKB/Swiss-Prot Function]