Rab10 (NM_016676) Mouse Untagged Clone

CAT#: MC205309

Rab10 (untagged) - Mouse RAB10, member RAS oncogene family (Rab10), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Rab10
• Synonyms: AW107754
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC056374
  GGGAAAAAGGTGGCTCTGGCCGGGGCGGCTCTGTTTCCTGGGGTTATGTAGCAGGGCTTGTCGGCTCGCG AGACCTCCCGCTGCCCTCGCCCGTGTCCTAGCGCGGGGTTTCTGCTCCGGGCGGAGGCCGTGTTCAAGCC CGCCGCGCTCCCTCGACGTAGAGCTCGCTCGTCCGCCCGTGGGAGCGTCCCGGCCGAGCTGCGCTGAGGG GGGAGGGGAGGCCATTTTGTCCCGACCGACTCCCCGGAACCGGGCGGAGCGGCTGGGAGAGGCTGCGGAG CCGCGGGCGCCGCCCCTCGGAGGCACGGGCGCCGCCACCGTCGGGGCTTCCTCGACGAGGCCGTTCGGAA GGTCTCCTGCTCCGTCTCGAGAGCTGCTTTCTCCTTCCGCACACGCTACCCGGCTGCTGCGGCCCCAGAA CGCCCGGGTGAGGAGTTGGTTGTAGTGAGCAGTTCCGATCCCTTGGGGCTACCGGCGGCGAGCGCCCGAG CCGCTCCTCCCAATGGCGAAGAAGACGTACGACCTGCTTTTCAAGCTGCTCCTGATCGGGGACTCGGGAG TGGGCAAGACCTGCGTCCTTTTTCGTTTTTCGGACGATGCCTTCAATACCACCTTTATTTCCACCATAGG AATAGACTTTAAGATCAAAACAGTGGAACTACAAGGAAAGAAGATCAAGCTACAGATATGGGACACAGCA GGCCAGGAGCGATTTCACACCATCACAACCTCCTACTACAGAGGAGCAATGGGCATCATGCTAGTGTATG ACATCACCAACGGTAAAAGCTTTGAGAACATCAGCAAGTGGCTTAGAAACATAGATGAGCATGCCAATGA AGATGTGGAAAGAATGTTACTAGGGAACAAGTGTGACATGGACGACAAGAGAGTTGTACCGAAAGGCAAA GGAGAACAGATTGCAAGGGAGCATGGTATTAGGTTTTTTGAGACTAGTGCAAAAGCAAATATAAACATCG AAAAGGCGTTCCTCACATTAGCTGAAGACATCCTCCGAAAGACCCCTGTAAAAGAACCCAACAGTGAAAA CGTAGATATCAGCAGTGGAGGAGGCGTGACGGGCTGGAAGAGCAAGTGCTGCTGAGTGCTCTCCTGTCCA TCTGCTGCCATCCACCATCCGGTTCTCTTCTTGCTGCAAAATAAAACACTCTGTCCATTTTTAACTCTAA ACAGATATTTTTGTTTCTCATCTTAACTATTCAATCCACCTATTTTATTTGTTCTTTCATCTGTGACTGC TTGCGGACTATTATAATTTTCTTCAAACAAACAAACAAAAATGTATAGAGAAATCATGTCTGTGAGTTCA TTTTGAGATTTACTTGCTCACTCAGCCCTGCACTTCAGTTGTATTATAGTCCAGTTCTTATCAACATTAA ACTAGAGCAATCATTTCAACTATTCTGCAAATTGTATAAGAATAAAAGTTAGAATTAACAATTTTATTTT GTACAACAGTGGGATTTTCTGTCATGAATAATGTGCTTGATCCCTATAATCTATAGACGTGATAGCAAAG AAACAAAAGCCAGGAAAACACTCATTTTCGCCTTGAACTGTATGTGGGTTAATTTGTCCTGTGCCTTATG TGGAAAGGAACGTCTTTGGTTTTCTTTTTTTGTTTTGGTGGAAGCATGAGCAGGAGACATTTCATCCCAG CATAAACTCCTTCAGATGCTTGTGGTTTGCTTGGCTGTATCTTTCACGATAGTTAACTGAGGACAAAGGG TAATGCAGAAGTGATATTTGATTTCCATTCTCATTCCCAGTGGCCTTGATATTTAAACTGATTCCTGCCA CCAGGTCCTTGGGCCACCCTGTCCCTGCGTCTCATCTTTCTGCATGCTGCTTTGTTTGCCCCTACTACTC CTGGTGTGAGTTATTTAAAGATGAAAGGTTTGTCAAGTTTAACATACAGCACTGATTTTACCTTGCTAAG TAAACAGAAAGATAAATTCTAACTGCCTATTAACTGTCAGTTAATTCGGGTCAGCCCCTCATTTACTCTC TCCCCAAACCTGCCCCGCTGTTGGCCTTCTGTCCCCCACCCCTTCCTGTCTATCCATGGAGTTTATGAAA TGGAAGAGTTAATTGCATGCACTAGTGTTTGGAGGGTGTTGTGGCTTGTCTTTCTAATTAGGTATATATC CTATTCACTTTCCTAGAGTAAACCTCCTAACCTGGATTTGACTAGTCTCCATTATGCCAGCTCCTCTGGC AGTTCGGCAGCCCAGGAAAGACTGGTTTTAAAAAAGAGCAAGAAGGAGTGGGTCTTAGTAGCGTTTGTCA AATGTATTGAGATTTGGCCTTTGAAGAACACATTTGGTATTAAGTTGTCTTTACTGTAAGATTTAGAAAT GCATTATAATATTATTAATTTCAAGTCCTATCTTTACATCCTCTCAGAAAACTTCTGATACCATGAATAT TTTAAAAAAGAAAAAGGACCGCAAAAGGCTTCTCGTGTAAAGCTGAGCACTCTGGCTCTGTCTGACCCGC CCTTCTCTCCCCTTTCTAGTTTGGCTTCATTGCTTCTCATTAGGATAGGGTAGGCTAAGTTCCCTATGCT GCTAGCATCCTAAGATGATACCTTTGTGGAAATAATTGTGAATAGCATGATTCATTTCAAGCAGAGGCTG AGTTTAGGACAGCAGCTACCATTGAGAAGATTTCTGTGACATGCATTTTAATGACCTCTTGGCTCACATA AACAATATAGGGACATATCTGCTAAAAGAACCCATGAATTTTTCAGATAGTGTCCCACAGACAATTCTAC ATGCCTCACTGGTGGCTCTTAGGGTTTCTTCCCTCACTTGACTTTATCATTGTTTACTAGTAAAAAGCAG CATTGCCAAATAACCCCTGATTTTCCACTATGAAAAATGCGATGTGTAAGCTTTTAAAGTTGTAGGTTAA ACCTCCTGTTGTTATCTTTGCTGTTTGTGTTGCTTCCTTCTATCTGGAATGTGGTAGCCACCTCTTTAAA CTTTTTTTAACCCTTAATTCAGTGACTTAAGGTTTGGAGATACACACTGGGATTTTGGCTAACAGACTGA CAGTTTTGTTGTTTGCATAATTATAATCGACATTGTACAGAGAAAGGATAAGGCTACCTTTGTTAAATCT GCACTTTCTGAATATCAAAAAAAAAAAAAAAAAAA
• Restriction Sites: AscI-NotI
• ACCN: NM_016676
• Insert Size: 603 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC056374, AAH56374
• RefSeq Size: 3185 bp
• RefSeq ORF: 603 bp
• Locus ID: 19325
• UniProt ID: P61027
• Cytogenetics: 12 1.71 cM
• Gene Summary: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. Finally, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion.[UniProtKB/Swiss-Prot Function]