Rtn4r (NM_022982) Mouse Untagged Clone

CAT#: MC205180

Rtn4r (untagged) - Mouse reticulon 4 receptor (Rtn4r), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Rtn4r
• Synonyms: NgR; NgR1; NOGOR
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC058381
  CCTGGCCCGCGCTGCGAGCGCCCCGCCAGTCCGCGCCGCCGCCCTCACCCTGTGCGCCCGCAGCCCGCGA GCCCAGCCCGGCCCGGTAGAGCGGAGCGCCGGAGCCTCGTCCCGCGGCCGGGCCGGGACCGGGCCGGAGC AGCGGCGCCTGGATGCGGACCCGGCCGCGCGCAGACGGGCGCCCGCCCCGAAGCCGCTTCCAGTGCCCGA CGCGCCCCGCTCGACCCCGAAGATGAAGAGGGCGTCCTCCGGAGGAAGCAGGCTGCTGGCATGGGTGTTA TGGCTACAGGCCTGGAGGGTAGCAACACCATGCCCTGGTGCTTGTGTGTGCTACAATGAGCCCAAGGTAA CAACAAGCTGCCCCCAGCAGGGTCTGCAGGCTGTGCCCACTGGCATCCCAGCCTCTAGCCAGCGAATCTT CCTGCATGGCAACCGAATCTCTCACGTGCCAGCTGCGAGCTTCCAGTCATGCCGAAATCTCACTATCCTG TGGCTGCACTCTAATGCGCTGGCTCGGATCGATGCTGCTGCCTTCACTGGTCTGACCCTCCTGGAGCAAC TAGATCTTAGTGATAATGCACAGCTTCATGTCGTGGACCCTACCACGTTCCACGGCCTGGGCCACCTGCA CACACTGCACCTAGACCGATGTGGCCTGCGGGAGCTGGGTCCCGGCCTATTCCGTGGACTAGCAGCTCTG CAGTACCTCTACCTACAAGACAACAATCTGCAGGCACTCCCTGACAACACCTTTCGAGACCTGGGCAACC TCACGCATCTCTTTCTGCATGGCAACCGTATCCCCAGTGTGCCTGAGCACGCTTTCCGTGGCCTGCACAG TCTTGACCGCCTCCTCTTGCACCAGAACCATGTGGCTCGTGTGCACCCACATGCCTTCCGGGACCTTGGC CGCCTCATGACCCTCTACCTGTTTGCCAACAACCTCTCCATGCTGCCTGCAGAGGTCCTAATGCCCCTGA GGTCTCTGCAGTACCTGCGACTCAATGACAACCCCTGGGTGTGTGACTGCCGGGCACGTCCACTCTGGGC CTGGCTGCAGAAGTTCCGAGGTTCCTCATCAGAGGTGCCCTGCAACCTGCCCCAACGCCTGGCAGACCGT GATCTTAAGCGCCTCGCTGCCAGTGACCTAGAGGGCTGTGCTGTGGCTTCAGGACCCTTCCGTCCCATCC AGACCAGTCAGCTCACTGATGAGGAGCTGCTGAGCCTCCCCAAGTGCTGCCAGCCAGATGCTGCAGACAA AGCCTCAGTACTGGAACCCGGGAGGCCAGCTTCTGCCGGAAACGCCCTCAAGGGACGTGTGCCTCCCGGT GACACTCCACCAGGCAATGGCTCAGGCCCTCGGCACATCAATGACTCTCCATTTGGAACTTTGCCCAGCT CTGCAGAGCCCCCACTGACTGCCCTGCGGCCTGGGGGTTCCGAGCCACCAGGACTTCCCACCACTGGTCC CCGCAGGAGGCCAGGTTGTTCCCGGAAGAATCGCACCCGCAGCCACTGCCGTCTGGGCCAGGCGGGAAGT GGGGCCAGTGGAACAGGGGACGCAGAGGGTTCAGGGGCTCTGCCTGCTCTGGCCTGCAGCCTTGCTCCTC TGGGCCTTGCACTGGTACTTTGGACAGTGCTTGGGCCCTGCTGACCAGCCACCAGCCACCAGGTGTGTGT ACATATGGGGTCTCCCTCCACGCCGCCAGCCAGAGCCAGGGACAGGCTCTGAGGGGCAGGCCAGGCCCTC CCTGACAGATGCCTCCCCACCAGCCCACCCCCATCTCCACCCCATCATGTTTACAGGGTTCCGGGGGTGG CGTTTGTTCCAGAACGCCACCTCCCACCCGGATCGCGGTATATAGAGATATGAATTTTATTTTACTTGTG TAAAATATCGGATGACGTGGAATAAAGAGCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: AscI-NotI
• ACCN: NM_022982
• Insert Size: 1422 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC058381, AAH58381
• RefSeq Size: 1959 bp
• RefSeq ORF: 1422 bp
• Locus ID: 65079
• UniProt ID: Q99PI8
• Cytogenetics: 16 A3
• Gene Summary: Receptor for RTN4, OMG and MAG (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:18411262, PubMed:22923615). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (PubMed:22406547). Can also bind heparin (PubMed:22406547). Intracellular signaling cascades are triggered via the coreceptor NGFR (By similarity). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). Mediates axonal growth inhibition (By similarity). Mediates axonal growth inhibition and plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:22923615). Plays a role in postnatal brain development (PubMed:27339102). Required for normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG (PubMed:26335717). Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development (PubMed:20093372). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).[UniProtKB/Swiss-Prot Function]