Nrarp (NM_025980) Mouse Untagged Clone

CAT#: MC204870

Nrarp (untagged) - Mouse Notch-regulated ankyrin repeat protein (Nrarp), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Nrarp
• Synonyms: 2700054M22Rik
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC069891
  GCCGAGGCGTACCTCGAGACACGCCCCGAGACAGCCCGGGGCCCGCACTGCAGCCGCCGCCCGCGCTAAG CCGGGGCGCGGCTCGCAGCCCTAGCTCTGCGGCAACATGAGCCAAGCCGAGCTGTCCACCTGCTCGGCGC CACAGACGCAGCGCATCTTCCAGGAAGCGGTGCGCAAGGGCAACACGCAGGAGCTGCAGTCGCTGCTGCA GAACATGACTAACTGCGAATTCAACGTGAACTCGTTCGGGCCGGAGGGCCAGACAGCACTACACCAGTCA GTCATCGACGGCAACCTGGAGCTGGTGAAGCTGTTGGTCAAGTTCGGAGCCGACATCCGCCTAGCTAACC GCGACGGCTGGAGCGCGCTACACATCGCCGCTTTCGGGGGCCACCAGGACATCGTGCTCTATCTCATCAC CAAGGCCAAGTACGCGGCCAGCGGCCGGTGATAGCCACCCGGACTCCGGCCCCTGGCCCCCACCCGCGTC GTCTCTGCTGTACCTTCCCGCCAACTACCTCGGTGTGCGCCAGGTTTGCTGGTCCGCGTGGAAATCGGGC TAAGTCTCTACGTCCGCGGCCACGACCAAAGTAGCGCATCCGTGGACCCCAGGGTTCGGCTCTCCGCAAA AGAGCGCCTCCCCTTGGCAGTCCTCTGAGCCCCGCGGGGCCCCAGAGCCTTCCCACGGCCCCGACCGCCT AGAGGGTGGGGGCGGGGCGCAGGCTCCAGTCCGTTTTGAAATTTGAGTCTCACACCGGGAGACTTCGGAA TCCCGAGATACCGGATCCTCCGCTTGAAATGTTTTCTCCGGAAGGTGAAAGGCGCGGGCGGACTCGCGCT CCAGCCGCCGCTCGTGAGACCCGGCCGCTCACAGTGCGGCGCCCGCCGCTGGCAGCCGCCAAACAACCAT TACCGGGCTCCACCATCTGCGCGCCCTCGCACTTAGGAAGGGAAGGGGACGCTCCGGGTTCCTGATGTCC TCAACTATTTATCACGTGTGTGTATATTTGTGGGTGAAGTTTGTGCGCCTGAGTTTTTTGTTTGGAAATA TTGTGCGTGGTTATGGGAGAAAGATGCATTTTTTTTCCTTTAAAACTAAAAACTTGAGTCTACCATTTTT TGGTTGCACTGAAAATACCGCCTAGCCCTATGGTTTTCCCATTGCTAGCCCCTCCCCCACCGAGTCCCTA ATCTTCCACACCTCATTCCTCTTTTCCTCTCCCTGGATTCTGAGTTTAGAGAGCCTAGGATCTGTCTCCC TTTCCCCTCCCGTGAGAGGCCACCATTCCCCACACAGGCTGGTTTAGCAAAGTTCCAAAGGGCTCTTGAA GCCCGCGTGGCTGGGACGTGGGGATTCTGAGAGCATGGTACCCTTCCTAGTGACTTCTATTATAGTTAAT AGTCGGTTGCACACTTTTTTAAAAAAGTAAATGAATTTGCCACGATTAAATGTCATAACATTTATGACAG AATATAAAATATTAACATATTTTAAGCCAAGTTTTAGGTGTATTTTTTTGAATCTTGGTTATGAACCCAA TTTTAAAGGGCGTTGTATCCAGCGTTGTGAAGGCTGTTGTGTACCCATATTTATATTTTTATAAAATTCC TATAAAGACTGTGAATCTCTCATACTATTGCTGAATGAGTGGAAGGGCTGCTGTGCTCTTTCTGCCTTCC CCAATCCCCATCCCCACCCTCAAACCCTGCTCCAAGGCCCTATTATGATCTGAGGATCCAGCCATGAGGG AGGGGCTGTGCCAAGGACCAGGGCTGGAGGAGGTGCTGGAGCGTCACTGGCTGTCCCAGAAAGGAGACTT CCTGGTTTCTGTGGTTCCAATTTTCTATGCATCTCCATTCCCCTTCTTGTTTTGATCCTGGGAAATAAAA GGGAGGCTGAATTATTCAAATTTAAATGAGGTTTCCCCTTCGTAGAAGTGCTGCTGACCCTGCGTGCAAA AATGGGGAGCACTTGAGGACACAGGTGGGTGGAGCCCTTTGTGCCGCCTGGCCATATTCTTCGGTCTTCT GCGCTTTTATGAACCAGTGTGGGAGGAATAGTGATAATGTCATGAGAATGGCAGACACTGAGACAAGCAC AGATTACTTCAAAAGGAGTTCTGTATGGTTTTTCTACACGCAAATGCCTTTTTAATTATGTTAATTAATG TTAAAACGTACTGGGCCTATGTTGAAGCTTCAGATGGGTCCTGGTTGGTCTCTTCTATCTGTATGAAGTC TGTGGCACACTCCTAAGCGTACGATATAGACTTGTAGCCCATCGTGAAAAATTTATAAATAAATTTTTCA TTGGTCTTTTTATATTAAAAAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_025980
• Insert Size: 345 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC069891, AAH69891
• RefSeq Size: 2345 bp
• RefSeq ORF: 345 bp
• Locus ID: 67122
• UniProt ID: Q91ZA8
• Cytogenetics: 2 A3
• Gene Summary: Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (By similarity). Involved in the regulation of canonical Wnt signaling by stabilizing LEF1 (By similarity). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (PubMed:21795391, PubMed:21998026).[UniProtKB/Swiss-Prot Function]